Deciphering NF-kappaB pathways in smoking-related lung carcinogenesis.

Thapa, R; Moglad, E; Goyal, A; Bhat, AA; Almalki, WH; Kazmi, I; Alzarea, SI; Ali, H; Oliver, BG; MacLoughlin, R; Dureja, H; Singh, SK; Dua, K; Gupta, G

Deciphering NF-kappaB pathways in smoking-related lung carcinogenesis.

Thapa, R Moglad, E Goyal, A Bhat, AA Almalki, WH Kazmi, I Alzarea, SI Ali, H Oliver, BG MacLoughlin, R Dureja, H Singh, SK Dua, K

Gupta, G

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Publication Type:: Journal Article
Citation:: EXCLI J, 2024, 23, pp. 991-1017
Issue Date:: 2024

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Field	Value	Language
dc.contributor.author	Thapa, R
dc.contributor.author	Moglad, E
dc.contributor.author	Goyal, A
dc.contributor.author	Bhat, AA
dc.contributor.author	Almalki, WH
dc.contributor.author	Kazmi, I
dc.contributor.author	Alzarea, SI
dc.contributor.author	Ali, H
dc.contributor.author	Oliver, BG
dc.contributor.author	MacLoughlin, R
dc.contributor.author	Dureja, H
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Gupta, G
dc.date.accessioned	2024-09-13T09:04:58Z
dc.date.available	2024-07-01
dc.date.available	2024-09-13T09:04:58Z
dc.date.issued	2024
dc.identifier.citation	EXCLI J, 2024, 23, pp. 991-1017
dc.identifier.issn	1611-2156
dc.identifier.uri	http://hdl.handle.net/10453/180819
dc.description.abstract	One of the main causes of death worldwide is lung cancer, which is largely caused by cigarette smoking. The crucial transcription factor NF-κB, which controls inflammatory responses and various cellular processes, is a constitutively present cytoplasmic protein strictly regulated by inhibitors like IκB proteins. Upon activation by external stimuli, it undergoes phosphorylation, translocates into the nucleus, and modulates the expression of specific genes. The incontrovertible association between pulmonary malignancy and tobacco consumption underscores and highlights a public health concern. Polycyclic aromatic hydrocarbons and nitrosamines, potent carcinogenic compounds present in the aerosol emitted from combusted tobacco, elicit profound deleterious effects upon inhalation, resulting in severe perturbation of pulmonary tissue integrity. The pathogenesis of smoking-induced lung cancer encompasses an intricate process wherein NF-κB activation plays a pivotal role, triggered by exposure to cigarette smoke through diverse signaling pathways, including those associated with oxidative stress and pro-inflammatory cytokines. Unraveling the participation of NF-κB in smoking-induced lung cancer provides pivotal insights into molecular processes, wherein intricate crosstalk between NF-κB and pathways such as MAPK and PI3K-Akt amplifies the inflammatory response, fostering an environment conducive to the formation of lung cancer. This study reviews the critical function of NF-κB in the complex molecular pathways linked to the initiation and advancement of lung carcinogenesis as well as potential treatment targets. See also the graphical abstract(Fig. 1).
dc.language	eng
dc.relation.ispartof	EXCLI J
dc.relation.isbasedon	10.17179/excli2024-7475
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Toxicology
dc.title	Deciphering NF-kappaB pathways in smoking-related lung carcinogenesis.
dc.type	Journal Article
utslib.citation.volume	23
utslib.location.activity	Germany
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/All Manual Groups
pubs.organisational-group	University of Technology Sydney/All Manual Groups/Centre for Inflammation (CFI)
pubs.organisational-group	University of Technology Sydney/All Manual Groups/Centre for Inflammation (CFI)/Associate Member
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-09-13T09:04:56Z
pubs.publication-status	Published online
pubs.volume	23

Abstract:

One of the main causes of death worldwide is lung cancer, which is largely caused by cigarette smoking. The crucial transcription factor NF-κB, which controls inflammatory responses and various cellular processes, is a constitutively present cytoplasmic protein strictly regulated by inhibitors like IκB proteins. Upon activation by external stimuli, it undergoes phosphorylation, translocates into the nucleus, and modulates the expression of specific genes. The incontrovertible association between pulmonary malignancy and tobacco consumption underscores and highlights a public health concern. Polycyclic aromatic hydrocarbons and nitrosamines, potent carcinogenic compounds present in the aerosol emitted from combusted tobacco, elicit profound deleterious effects upon inhalation, resulting in severe perturbation of pulmonary tissue integrity. The pathogenesis of smoking-induced lung cancer encompasses an intricate process wherein NF-κB activation plays a pivotal role, triggered by exposure to cigarette smoke through diverse signaling pathways, including those associated with oxidative stress and pro-inflammatory cytokines. Unraveling the participation of NF-κB in smoking-induced lung cancer provides pivotal insights into molecular processes, wherein intricate crosstalk between NF-κB and pathways such as MAPK and PI3K-Akt amplifies the inflammatory response, fostering an environment conducive to the formation of lung cancer. This study reviews the critical function of NF-κB in the complex molecular pathways linked to the initiation and advancement of lung carcinogenesis as well as potential treatment targets. See also the graphical abstract(Fig. 1).

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http://hdl.handle.net/10453/180819