Cancer-associated fibroblast cell surface markers as potential biomarkers or therapeutic targets in lung cancer

Tokhanbigli, S; Haghi, M; Dua, K; Oliver, BGG

Cancer-associated fibroblast cell surface markers as potential biomarkers or therapeutic targets in lung cancer

Tokhanbigli, S Haghi, M Dua, K

Oliver, BGG

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Publisher:: OAE Publishing Inc.
Publication Type:: Journal Article
Citation:: Cancer Drug Resistance

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Field	Value	Language
dc.contributor.author	Tokhanbigli, S
dc.contributor.author	Haghi, M
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Oliver, BGG
dc.date.accessioned	2024-09-13T09:06:53Z
dc.date.available	2024-09-13T09:06:53Z
dc.identifier.citation	Cancer Drug Resistance
dc.identifier.issn	2578-532X
dc.identifier.uri	http://hdl.handle.net/10453/180820
dc.description.abstract	<jats:p>Cancer-associated fibroblasts (CAFs) are the vital constituent of the tumor microenvironment, and in communication with other cells, they contribute to tumor progression and metastasis. Fibroblasts are the proposed origin of CAFs, which are mediated by pro-inflammatory cytokines and the recruitment of immune cells akin to wound healing. Although various studies have identified different subpopulations of CAFs in lung cancer, the heterogeneity of CAFs, particularly in lung cancer, and their potential as a therapeutic target remain largely unknown. Notwithstanding CAFs were previously thought to have predominantly tumor-promoting features, their pro- or anti-tumorigenic properties may depend on various conditions and cell origins. The absence of distinct markers to identify CAF subpopulations presents obstacles to the successful therapeutic targeting and treatment of CAFs in cancer. Human clinical and animal studies targeting CAFs have shown that targeting CAFs exacerbates the disease progression, suggesting that subpopulations of CAFs may exert opposing functions in cancer progression. Therefore, it is essential to pinpoint specific markers capable of characterizing these subpopulations and revealing their mechanisms of function. The cell-specific surface markers of CAFs will serve as an initial step in investigating precise CAF subpopulations and their role in diagnosing and targeting therapy against cancer-promoting CAF subsets in lung cancer.</jats:p>
dc.language	en
dc.publisher	OAE Publishing Inc.
dc.relation.ispartof	Cancer Drug Resistance
dc.relation.isbasedon	10.20517/cdr.2024.55
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Cancer-associated fibroblast cell surface markers as potential biomarkers or therapeutic targets in lung cancer
dc.type	Journal Article
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/All Manual Groups
pubs.organisational-group	University of Technology Sydney/All Manual Groups/Centre for Inflammation (CFI)
pubs.organisational-group	University of Technology Sydney/All Manual Groups/Centre for Inflammation (CFI)/Associate Member
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-09-13T09:06:49Z
pubs.publication-status	Published online

Abstract:

Cancer-associated fibroblasts (CAFs) are the vital constituent of the tumor microenvironment, and in communication with other cells, they contribute to tumor progression and metastasis. Fibroblasts are the proposed origin of CAFs, which are mediated by pro-inflammatory cytokines and the recruitment of immune cells akin to wound healing. Although various studies have identified different subpopulations of CAFs in lung cancer, the heterogeneity of CAFs, particularly in lung cancer, and their potential as a therapeutic target remain largely unknown. Notwithstanding CAFs were previously thought to have predominantly tumor-promoting features, their pro- or anti-tumorigenic properties may depend on various conditions and cell origins. The absence of distinct markers to identify CAF subpopulations presents obstacles to the successful therapeutic targeting and treatment of CAFs in cancer. Human clinical and animal studies targeting CAFs have shown that targeting CAFs exacerbates the disease progression, suggesting that subpopulations of CAFs may exert opposing functions in cancer progression. Therefore, it is essential to pinpoint specific markers capable of characterizing these subpopulations and revealing their mechanisms of function. The cell-specific surface markers of CAFs will serve as an initial step in investigating precise CAF subpopulations and their role in diagnosing and targeting therapy against cancer-promoting CAF subsets in lung cancer.

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http://hdl.handle.net/10453/180820