Engineering antibacterial bioceramics: Design principles and mechanisms of action.

Nguyen, NH; Lu, Z; Elbourne, A; Vasilev, K; Roohani, I; Zreiqat, H; Truong, VK

Engineering antibacterial bioceramics: Design principles and mechanisms of action.

Nguyen, NH Lu, Z Elbourne, A Vasilev, K Roohani, I

Zreiqat, H Truong, VK

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Mater Today Bio, 2024, 26, pp. 101069
Issue Date:: 2024-06

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Field	Value	Language
dc.contributor.author	Nguyen, NH
dc.contributor.author	Lu, Z
dc.contributor.author	Elbourne, A
dc.contributor.author	Vasilev, K
dc.contributor.author	Roohani, I https://orcid.org/0009-0000-3678-3455
dc.contributor.author	Zreiqat, H
dc.contributor.author	Truong, VK
dc.date.accessioned	2024-10-02T23:06:16Z
dc.date.available	2024-04-25
dc.date.available	2024-10-02T23:06:16Z
dc.date.issued	2024-06
dc.identifier.citation	Mater Today Bio, 2024, 26, pp. 101069
dc.identifier.issn	2590-0064
dc.identifier.issn	2590-0064
dc.identifier.uri	http://hdl.handle.net/10453/181146
dc.description.abstract	The urgency to address skeletal abnormalities and diseases through innovative approaches has led to a significant interdisciplinary convergence of engineering, 3D printing, and design in developing individualised bioceramic bioscaffolds. This review explores into the recent advancements and future trajectory of non-antibiotic antibacterial bioceramics in bone tissue engineering, an importance given the escalating challenges of orthopaedic infections, antibiotic resistance, and emergent pathogens. Initially, the review provides an in-depth exploration of the complex interactions among bacteria, immune cells, and bioceramics in clinical contexts, highlighting the multifaceted nature of infection dynamics, including protein adsorption, immunological responses, bacterial adherence, and endotoxin release. Then, focus on the next-generation bioceramics designed to offer multifunctionality, especially in delivering antibacterial properties independent of traditional antibiotics. A key highlight of this study is the exploration of smart antibacterial bioceramics, marking a revolutionary stride in medical implant technology. The review also aims to guide the ongoing development and clinical adoption of bioceramic materials, focusing on their dual capabilities in promoting bone regeneration and exhibiting antibacterial properties. These next-generation bioceramics represent a paradigm shift in medical implant technology, offering multifunctional benefits that transcend traditional approaches.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Mater Today Bio
dc.relation.isbasedon	10.1016/j.mtbio.2024.101069
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	3403 Macromolecular and materials chemistry
dc.subject.classification	4003 Biomedical engineering
dc.subject.classification	4016 Materials engineering
dc.title	Engineering antibacterial bioceramics: Design principles and mechanisms of action.
dc.type	Journal Article
utslib.citation.volume	26
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-10-02T23:06:13Z
pubs.publication-status	Published online
pubs.volume	26

Abstract:

The urgency to address skeletal abnormalities and diseases through innovative approaches has led to a significant interdisciplinary convergence of engineering, 3D printing, and design in developing individualised bioceramic bioscaffolds. This review explores into the recent advancements and future trajectory of non-antibiotic antibacterial bioceramics in bone tissue engineering, an importance given the escalating challenges of orthopaedic infections, antibiotic resistance, and emergent pathogens. Initially, the review provides an in-depth exploration of the complex interactions among bacteria, immune cells, and bioceramics in clinical contexts, highlighting the multifaceted nature of infection dynamics, including protein adsorption, immunological responses, bacterial adherence, and endotoxin release. Then, focus on the next-generation bioceramics designed to offer multifunctionality, especially in delivering antibacterial properties independent of traditional antibiotics. A key highlight of this study is the exploration of smart antibacterial bioceramics, marking a revolutionary stride in medical implant technology. The review also aims to guide the ongoing development and clinical adoption of bioceramic materials, focusing on their dual capabilities in promoting bone regeneration and exhibiting antibacterial properties. These next-generation bioceramics represent a paradigm shift in medical implant technology, offering multifunctional benefits that transcend traditional approaches.

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http://hdl.handle.net/10453/181146