Development of algorithms for estimating the Child Health Utility 9D from Caregiver Priorities and Child Health Index of Life with Disabilities.
Tonmukayakul, U
Willoughby, K
Mihalopoulos, C
Reddihough, D
Mulhern, B
Carter, R
Robinson, S
Chen, G
- Publisher:
- SPRINGER
- Publication Type:
- Journal Article
- Citation:
- Qual Life Res, 2024, 33, (7), pp. 1881-1891
- Issue Date:
- 2024-07
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Tonmukayakul, U | |
dc.contributor.author | Willoughby, K | |
dc.contributor.author | Mihalopoulos, C | |
dc.contributor.author | Reddihough, D | |
dc.contributor.author |
Mulhern, B |
|
dc.contributor.author | Carter, R | |
dc.contributor.author | Robinson, S | |
dc.contributor.author | Chen, G | |
dc.date.accessioned | 2024-10-09T00:09:20Z | |
dc.date.available | 2024-04-03 | |
dc.date.available | 2024-10-09T00:09:20Z | |
dc.date.issued | 2024-07 | |
dc.identifier.citation | Qual Life Res, 2024, 33, (7), pp. 1881-1891 | |
dc.identifier.issn | 0962-9343 | |
dc.identifier.issn | 1573-2649 | |
dc.identifier.uri | http://hdl.handle.net/10453/181265 | |
dc.description.abstract | PURPOSE: The primary aim was to determine Child Health Utility 9D (CHU9D) utilities from the Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD) for non-ambulatory children with cerebral palsy (CP). METHODS: One hundred and eight surveys completed by Australian parents/caregivers of children with CP were analysed. Spearman's coefficients were used to investigate the correlations between the two instruments. Ordinary least square, robust MM-estimator, and generalised linear models (GLM) with four combinations of families and links were developed to estimate CHU9D utilities from either the CPCHILD total score or CPCHILD domains scores. Internal validation was performed using 5-fold cross-validation and random sampling validation. The best performing algorithms were identified based on mean absolute error (MAE), concordance correlation coefficient (CCC), and the difference between predicted and observed means of CHU9D. RESULTS: Moderate correlations (ρ 0.4-0.6) were observed between domains of the CHU9D and CPCHILD instruments. The best performing algorithm when considering the CPCHILD total score was a generalised linear regression (GLM) Gamma family and logit link (MAE = 0.156, CCC = 0.508). Additionally, the GLM Gamma family logit link using CPCHILD comfort and emotion, quality of life, and health domain scores also performed well (MAE = 0.152, CCC = 0.552). CONCLUSION: This study established algorithms for estimating CHU9D utilities from CPCHILD scores for non-ambulatory children with CP. The determined algorithms can be valuable for estimating quality-adjusted life years for cost-utility analysis when only the CPCHILD instrument is available. However, further studies with larger sample sizes and external validation are recommended to validate these findings. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | SPRINGER | |
dc.relation.ispartof | Qual Life Res | |
dc.relation.isbasedon | 10.1007/s11136-024-03661-9 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 1117 Public Health and Health Services, 1701 Psychology | |
dc.subject.classification | Health Policy & Services | |
dc.subject.classification | 42 Health sciences | |
dc.subject.classification | 44 Human society | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Child | |
dc.subject.mesh | Male | |
dc.subject.mesh | Female | |
dc.subject.mesh | Caregivers | |
dc.subject.mesh | Algorithms | |
dc.subject.mesh | Quality of Life | |
dc.subject.mesh | Disabled Children | |
dc.subject.mesh | Australia | |
dc.subject.mesh | Surveys and Questionnaires | |
dc.subject.mesh | Cerebral Palsy | |
dc.subject.mesh | Child, Preschool | |
dc.subject.mesh | Child Health | |
dc.subject.mesh | Adolescent | |
dc.subject.mesh | Psychometrics | |
dc.subject.mesh | Health Status | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Cerebral Palsy | |
dc.subject.mesh | Psychometrics | |
dc.subject.mesh | Health Status | |
dc.subject.mesh | Algorithms | |
dc.subject.mesh | Quality of Life | |
dc.subject.mesh | Adolescent | |
dc.subject.mesh | Child | |
dc.subject.mesh | Child, Preschool | |
dc.subject.mesh | Caregivers | |
dc.subject.mesh | Disabled Children | |
dc.subject.mesh | Australia | |
dc.subject.mesh | Female | |
dc.subject.mesh | Male | |
dc.subject.mesh | Surveys and Questionnaires | |
dc.subject.mesh | Child Health | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Child | |
dc.subject.mesh | Male | |
dc.subject.mesh | Female | |
dc.subject.mesh | Caregivers | |
dc.subject.mesh | Algorithms | |
dc.subject.mesh | Quality of Life | |
dc.subject.mesh | Disabled Children | |
dc.subject.mesh | Australia | |
dc.subject.mesh | Surveys and Questionnaires | |
dc.subject.mesh | Cerebral Palsy | |
dc.subject.mesh | Child, Preschool | |
dc.subject.mesh | Child Health | |
dc.subject.mesh | Adolescent | |
dc.subject.mesh | Psychometrics | |
dc.subject.mesh | Health Status | |
dc.title | Development of algorithms for estimating the Child Health Utility 9D from Caregiver Priorities and Child Health Index of Life with Disabilities. | |
dc.type | Journal Article | |
utslib.citation.volume | 33 | |
utslib.location.activity | Netherlands | |
utslib.for | 1117 Public Health and Health Services | |
utslib.for | 1701 Psychology | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Health | |
pubs.organisational-group | University of Technology Sydney/UTS Groups | |
pubs.organisational-group | University of Technology Sydney/UTS Groups/Centre for Health Economics Research and Evaluation (CHERE) | |
utslib.copyright.status | open_access | * |
dc.rights.license | This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2024-10-09T00:09:18Z | |
pubs.issue | 7 | |
pubs.publication-status | Published | |
pubs.volume | 33 | |
utslib.citation.issue | 7 |
Abstract:
PURPOSE: The primary aim was to determine Child Health Utility 9D (CHU9D) utilities from the Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD) for non-ambulatory children with cerebral palsy (CP). METHODS: One hundred and eight surveys completed by Australian parents/caregivers of children with CP were analysed. Spearman's coefficients were used to investigate the correlations between the two instruments. Ordinary least square, robust MM-estimator, and generalised linear models (GLM) with four combinations of families and links were developed to estimate CHU9D utilities from either the CPCHILD total score or CPCHILD domains scores. Internal validation was performed using 5-fold cross-validation and random sampling validation. The best performing algorithms were identified based on mean absolute error (MAE), concordance correlation coefficient (CCC), and the difference between predicted and observed means of CHU9D. RESULTS: Moderate correlations (ρ 0.4-0.6) were observed between domains of the CHU9D and CPCHILD instruments. The best performing algorithm when considering the CPCHILD total score was a generalised linear regression (GLM) Gamma family and logit link (MAE = 0.156, CCC = 0.508). Additionally, the GLM Gamma family logit link using CPCHILD comfort and emotion, quality of life, and health domain scores also performed well (MAE = 0.152, CCC = 0.552). CONCLUSION: This study established algorithms for estimating CHU9D utilities from CPCHILD scores for non-ambulatory children with CP. The determined algorithms can be valuable for estimating quality-adjusted life years for cost-utility analysis when only the CPCHILD instrument is available. However, further studies with larger sample sizes and external validation are recommended to validate these findings.
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