A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer's disease.

Wang, J; Shangguan, P; Chen, X; Zhong, Y; Lin, M; He, M; Liu, Y; Zhou, Y; Pang, X; Han, L; Lu, M; Wang, X; Liu, Y; Yang, H; Chen, J; Song, C; Zhang, J; Wang, X; Shi, B; Tang, BZ

A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer's disease.

Wang, J Shangguan, P Chen, X Zhong, Y Lin, M He, M Liu, Y Zhou, Y Pang, X Han, L Lu, M Wang, X Liu, Y Yang, H Chen, J Song, C Zhang, J Wang, X Shi, B

Tang, BZ

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Publisher:: NATURE PORTFOLIO
Publication Type:: Journal Article
Citation:: Nat Commun, 2024, 15, (1), pp. 705
Issue Date:: 2024-01-24

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Field	Value	Language
dc.contributor.author	Wang, J
dc.contributor.author	Shangguan, P
dc.contributor.author	Chen, X
dc.contributor.author	Zhong, Y
dc.contributor.author	Lin, M
dc.contributor.author	He, M
dc.contributor.author	Liu, Y
dc.contributor.author	Zhou, Y
dc.contributor.author	Pang, X
dc.contributor.author	Han, L
dc.contributor.author	Lu, M
dc.contributor.author	Wang, X
dc.contributor.author	Liu, Y
dc.contributor.author	Yang, H
dc.contributor.author	Chen, J
dc.contributor.author	Song, C
dc.contributor.author	Zhang, J
dc.contributor.author	Wang, X
dc.contributor.author	Shi, B https://orcid.org/0000-0002-1043-3163
dc.contributor.author	Tang, BZ
dc.date.accessioned	2024-10-21T00:26:05Z
dc.date.available	2024-01-02
dc.date.available	2024-10-21T00:26:05Z
dc.date.issued	2024-01-24
dc.identifier.citation	Nat Commun, 2024, 15, (1), pp. 705
dc.identifier.issn	2041-1723
dc.identifier.issn	2041-1723
dc.identifier.uri	http://hdl.handle.net/10453/181469
dc.description.abstract	Toxic amyloid-beta (Aβ) plaque and harmful inflammation are two leading symptoms of Alzheimer's disease (AD). However, precise AD therapy is unrealizable due to the lack of dual-targeting therapy function, poor BBB penetration, and low imaging sensitivity. Here, we design a near-infrared-II aggregation-induced emission (AIE) nanotheranostic for precise AD therapy. The anti-quenching emission at 1350 nm accurately monitors the in vivo BBB penetration and specifically binding of nanotheranostic with plaques. Triggered by reactive oxygen species (ROS), two encapsulated therapeutic-type AIE molecules are controllably released to activate a self-enhanced therapy program. One specifically inhibits the Aβ fibrils formation, degrades Aβ fibrils, and prevents the reaggregation via multi-competitive interactions that are verified by computational analysis, which further alleviates the inflammation. Another effectively scavenges ROS and inflammation to remodel the cerebral redox balance and enhances the therapy effect, together reversing the neurotoxicity and achieving effective behavioral and cognitive improvements in the female AD mice model.
dc.format	Electronic
dc.language	eng
dc.publisher	NATURE PORTFOLIO
dc.relation.ispartof	Nat Commun
dc.relation.isbasedon	10.1038/s41467-024-44737-x
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Female
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Reactive Oxygen Species
dc.subject.mesh	Amyloid beta-Peptides
dc.subject.mesh	Cytoskeleton
dc.subject.mesh	Inflammation
dc.subject.mesh	Plaque, Amyloid
dc.subject.mesh	Cytoskeleton
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Inflammation
dc.subject.mesh	Reactive Oxygen Species
dc.subject.mesh	Female
dc.subject.mesh	Amyloid beta-Peptides
dc.subject.mesh	Plaque, Amyloid
dc.subject.mesh	Female
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Reactive Oxygen Species
dc.subject.mesh	Amyloid beta-Peptides
dc.subject.mesh	Cytoskeleton
dc.subject.mesh	Inflammation
dc.subject.mesh	Plaque, Amyloid
dc.title	A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer's disease.
dc.type	Journal Article
utslib.citation.volume	15
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-10-21T00:25:58Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	15
utslib.citation.issue	1

Abstract:

Toxic amyloid-beta (Aβ) plaque and harmful inflammation are two leading symptoms of Alzheimer's disease (AD). However, precise AD therapy is unrealizable due to the lack of dual-targeting therapy function, poor BBB penetration, and low imaging sensitivity. Here, we design a near-infrared-II aggregation-induced emission (AIE) nanotheranostic for precise AD therapy. The anti-quenching emission at 1350 nm accurately monitors the in vivo BBB penetration and specifically binding of nanotheranostic with plaques. Triggered by reactive oxygen species (ROS), two encapsulated therapeutic-type AIE molecules are controllably released to activate a self-enhanced therapy program. One specifically inhibits the Aβ fibrils formation, degrades Aβ fibrils, and prevents the reaggregation via multi-competitive interactions that are verified by computational analysis, which further alleviates the inflammation. Another effectively scavenges ROS and inflammation to remodel the cerebral redox balance and enhances the therapy effect, together reversing the neurotoxicity and achieving effective behavioral and cognitive improvements in the female AD mice model.

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http://hdl.handle.net/10453/181469