| Field |
Value |
Language |
|
dc.contributor.author |
Mashkani, SMH |
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|
dc.contributor.author |
Bishop, D |
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|
dc.contributor.author |
Westerhausen, MT |
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|
dc.contributor.author |
Adlard, PA |
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|
dc.contributor.author |
Golzan, SM |
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dc.date.accessioned |
2024-11-10T22:06:46Z |
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dc.date.available |
2024-11-10T22:06:46Z |
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dc.identifier.citation |
Metallomics |
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|
dc.identifier.issn |
1756-591X |
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dc.identifier.uri |
http://hdl.handle.net/10453/181822
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|
dc.description.abstract |
<jats:title>ABSTRACT</jats:title>
<jats:p>Transition metals like copper, iron, and zinc are vital for normal central nervous system function and are also linked to neurodegeneration, particularly in the onset and progression of Alzheimer's disease (AD). Their alterations in AD, identified prior to amyloid plaque aggregation, offer a unique target for staging pre-amyloid AD. However, analysing their levels in the brain is extremely challenging, necessitating the development of alternative approaches. Here, we utilised laser ablation-inductively coupled plasma-mass spectrometry and solution nebulisation-inductively coupled plasma-mass spectrometry to quantitatively measure Cu, Fe, and Zn concentrations in the retina and hippocampus samples obtained from human donors (i.e., AD and healthy controls), and in the APP/PS1 mouse model of AD, and Wild Type controls, aged 9 and 18 months. Our findings revealed significantly elevated Cu, Fe, and Zn levels in the retina (*p < 0.05, **p < 0.01, ***p < 0.001) and hippocampus (*p < 0.05, *p < 0.05, *p < 0.05) of human AD samples compared to healthy controls. Conversely, APP/PS1 mouse models exhibited notably lower metal levels in the same regions compared to WT mice, Cu, Fe, and Zn levels in the retina (**p < 0.01, *p < 0.05, *p < 0.05) and hippocampus (**p < 0.01, **p < 0.01, *p < 0.05). The contrasting metal profiles in human and mouse samples, yet similar patterns within each species' retina and brain, suggest the retina mirrors cerebral metal dyshomeostasis in AD. Our findings lay the groundwork for staging pre-AD pathophysiology through assessment of transition metal levels in the retina.</jats:p> |
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dc.language |
en |
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dc.publisher |
Oxford University Press (OUP) |
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dc.relation |
http://purl.org/au-research/grants/nhmrc/1105930
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|
|
dc.relation |
ANZ Trustees Limited |
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dc.relation.ispartof |
Metallomics |
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|
dc.relation.isbasedon |
10.1093/mtomcs/mfae053 |
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dc.rights |
info:eu-repo/semantics/openAccess |
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|
dc.subject |
03 Chemical Sciences |
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|
dc.subject.classification |
Analytical Chemistry |
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|
dc.subject.classification |
34 Chemical sciences |
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|
dc.title |
Alterations in Zinc, Copper, and Iron Levels in the Retina and Brain of Alzheimer's Disease Patients and the APP/PS1 Mouse Model |
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dc.type |
Journal Article |
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utslib.for |
03 Chemical Sciences |
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pubs.organisational-group |
University of Technology Sydney |
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pubs.organisational-group |
University of Technology Sydney/Faculty of Health |
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pubs.organisational-group |
University of Technology Sydney/UTS Groups |
|
|
pubs.organisational-group |
University of Technology Sydney/UTS Groups/Centre for Health Technologies (CHT) |
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utslib.copyright.status |
open_access |
* |
|
dc.rights.license |
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ |
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|
dc.rights.license |
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ |
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dc.date.updated |
2024-11-10T22:06:44Z |
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pubs.publication-status |
Published online |
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