Microneedles for various ocular diseases

Verma, N; Puri, V; Sharma, A; Dheer, D; Kanojia, N; Thapa, K; Thakur, N; Sood, P; Dua, K

Microneedles for various ocular diseases

Verma, N Puri, V Sharma, A Dheer, D Kanojia, N Thapa, K Thakur, N Sood, P Dua, K

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Publisher:: Elsevier
Publication Type:: Chapter
Citation:: Design and Applications of Microneedles in Drug Delivery and Therapeutics, 2024, pp. 303-326
Issue Date:: 2024-01-01

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Field	Value	Language
dc.contributor.author	Verma, N
dc.contributor.author	Puri, V
dc.contributor.author	Sharma, A
dc.contributor.author	Dheer, D
dc.contributor.author	Kanojia, N
dc.contributor.author	Thapa, K
dc.contributor.author	Thakur, N
dc.contributor.author	Sood, P
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2024-11-11T22:57:07Z
dc.date.available	2024-11-11T22:57:07Z
dc.date.issued	2024-01-01
dc.identifier.citation	Design and Applications of Microneedles in Drug Delivery and Therapeutics, 2024, pp. 303-326
dc.identifier.isbn	9780443138812
dc.identifier.uri	http://hdl.handle.net/10453/181846
dc.description.abstract	Eye disorders and injuries are a major clinical problem all over the world. The presence of ocular obstacles and clearance systems makes safe and effective drug administration to the eye difficult. Traditional eye drops, gels, and ointments are most commonly used in ordinary practice. Unfortunately, patients typically do not tolerate them well because of the need for regular use as well as the discomfort during application. As a result, innovative drug delivery methods with improved biopharmaceutical properties are the focus of continuing scientific research. Microtechnology advancements in recent years have resulted in a significant advancement in the creation of microneedle-based devices as an alternate, noninvasive method of giving medications to the eye. The goal of this chapter is to present the most recent advancements in the field of obtaining microneedle ocular patches. The chapter presents the most essential manufacturing technologies, microneedle classification, and research findings on the ophthalmic application of microneedles. Furthermore, insights into the beneficial therapeutic applications that MNs can bring to various ocular illnesses are presented. Glaucoma, age-related macular degeneration, uveitis, retinal vascular occlusion, and retinitis pigmentosa are the most commonly discussed.
dc.language	en
dc.publisher	Elsevier
dc.relation.ispartof	Design and Applications of Microneedles in Drug Delivery and Therapeutics
dc.relation.isbasedon	10.1016/B978-0-443-13881-2.00019-9
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Microneedles for various ocular diseases
dc.type	Chapter
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Inflammation (CFI)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Inflammation (CFI)/Associate Member
pubs.organisational-group	University of Technology Sydney/UTS Groups/Australian Research Consortium in Complementary and Integrative Medicine (ARCCIM)
utslib.copyright.status	closed_access	*
dc.date.updated	2024-11-11T22:57:05Z
pubs.publication-status	Published

Abstract:

Eye disorders and injuries are a major clinical problem all over the world. The presence of ocular obstacles and clearance systems makes safe and effective drug administration to the eye difficult. Traditional eye drops, gels, and ointments are most commonly used in ordinary practice. Unfortunately, patients typically do not tolerate them well because of the need for regular use as well as the discomfort during application. As a result, innovative drug delivery methods with improved biopharmaceutical properties are the focus of continuing scientific research. Microtechnology advancements in recent years have resulted in a significant advancement in the creation of microneedle-based devices as an alternate, noninvasive method of giving medications to the eye. The goal of this chapter is to present the most recent advancements in the field of obtaining microneedle ocular patches. The chapter presents the most essential manufacturing technologies, microneedle classification, and research findings on the ophthalmic application of microneedles. Furthermore, insights into the beneficial therapeutic applications that MNs can bring to various ocular illnesses are presented. Glaucoma, age-related macular degeneration, uveitis, retinal vascular occlusion, and retinitis pigmentosa are the most commonly discussed.

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http://hdl.handle.net/10453/181846