A Comprehensive Numerical Study on the Transport and Deposition of Nasal Sprayed Pharmaceutical Aerosols in a Nasal-To-Lung Respiratory Tract Model

Huang, X; Yin, Y; Saha, G; Francis, I; Saha, SC

A Comprehensive Numerical Study on the Transport and Deposition of Nasal Sprayed Pharmaceutical Aerosols in a Nasal-To-Lung Respiratory Tract Model

Huang, X

Yin, Y Saha, G

Francis, I

Saha, SC

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Publisher:: WILEY-V C H VERLAG GMBH
Publication Type:: Journal Article
Citation:: Particle and Particle Systems Characterization, 2024
Issue Date:: 2024-01-01

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Field	Value	Language
dc.contributor.author	Huang, X https://orcid.org/0000-0002-4761-7652
dc.contributor.author	Yin, Y
dc.contributor.author	Saha, G https://orcid.org/0000-0001-6467-298X
dc.contributor.author	Francis, I https://orcid.org/0000-0002-6382-4037
dc.contributor.author	Saha, SC
dc.date.accessioned	2024-11-13T07:11:05Z
dc.date.available	2024-11-13T07:11:05Z
dc.date.issued	2024-01-01
dc.identifier.citation	Particle and Particle Systems Characterization, 2024
dc.identifier.issn	0934-0866
dc.identifier.issn	1521-4117
dc.identifier.uri	http://hdl.handle.net/10453/181881
dc.description.abstract	Utilizing a computed tomography (CT)-based realistic nasal-to-lung respiratory tract model allows for a comprehensive investigation of the transport and deposition of nasal sprayed aerosols. This study has three main objectives: first, to determine the optimal mesh that achieves the quickest convergence for computational fluid-particle dynamics (CFPD) simulations of a nasal-to-lung nasal respiratory tract by assessing the performance of different element types, sizes, and prism boundary layers; second, to design and validate a numerical method to compare grid data with different mesh structures and densities for simulation result validation; and finally, to observe and analyze fluid-particle dynamics in the respiratory tract to aid in the development of nasal sprayed medications. This study involves reverse-engineering a realistic and anatomically accurate respiratory tract model from CT scans. Results reveal that the optimal numerical approach for minimum calculation time is the polyhedral hybrid mesh with four boundary prism layers and the SIMPLE pressure-velocity coupling scheme. Furthermore, observations of particle dynamics reveal that the vocal cords' location contains a concentration site of deposited small aerosols due to the turbulent airflow in the region. The optimal diameters of nasal sprayed aerosols to target each region are concluded in the end.
dc.language	English
dc.publisher	WILEY-V C H VERLAG GMBH
dc.relation.ispartof	Particle and Particle Systems Characterization
dc.relation.isbasedon	10.1002/ppsc.202400004
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0299 Other Physical Sciences, 0904 Chemical Engineering, 0913 Mechanical Engineering
dc.subject.classification	Chemical Engineering
dc.subject.classification	4004 Chemical engineering
dc.subject.classification	4017 Mechanical engineering
dc.subject.classification	4018 Nanotechnology
dc.title	A Comprehensive Numerical Study on the Transport and Deposition of Nasal Sprayed Pharmaceutical Aerosols in a Nasal-To-Lung Respiratory Tract Model
dc.type	Journal Article
utslib.for	0299 Other Physical Sciences
utslib.for	0904 Chemical Engineering
utslib.for	0913 Mechanical Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated	2024-11-13T07:11:03Z
pubs.publication-status	Published

Abstract:

Utilizing a computed tomography (CT)-based realistic nasal-to-lung respiratory tract model allows for a comprehensive investigation of the transport and deposition of nasal sprayed aerosols. This study has three main objectives: first, to determine the optimal mesh that achieves the quickest convergence for computational fluid-particle dynamics (CFPD) simulations of a nasal-to-lung nasal respiratory tract by assessing the performance of different element types, sizes, and prism boundary layers; second, to design and validate a numerical method to compare grid data with different mesh structures and densities for simulation result validation; and finally, to observe and analyze fluid-particle dynamics in the respiratory tract to aid in the development of nasal sprayed medications. This study involves reverse-engineering a realistic and anatomically accurate respiratory tract model from CT scans. Results reveal that the optimal numerical approach for minimum calculation time is the polyhedral hybrid mesh with four boundary prism layers and the SIMPLE pressure-velocity coupling scheme. Furthermore, observations of particle dynamics reveal that the vocal cords' location contains a concentration site of deposited small aerosols due to the turbulent airflow in the region. The optimal diameters of nasal sprayed aerosols to target each region are concluded in the end.

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http://hdl.handle.net/10453/181881