Highly disordered and resorbable lithiated nanoparticles with osteogenic and angiogenic properties.

Romanazzo, S; Zhu, Y; Sheikh, R; Lin, X; Liu, H; He, T-C; Roohani, I

Highly disordered and resorbable lithiated nanoparticles with osteogenic and angiogenic properties.

Romanazzo, S Zhu, Y Sheikh, R Lin, X Liu, H He, T-C Roohani, I

Permalink

Publisher:: ROYAL SOC CHEMISTRY
Publication Type:: Journal Article
Citation:: J Mater Chem B, 2024, 12, (38), pp. 9575-9591
Issue Date:: 2024-10-02

Closed Access

	Filename	Description	Size
	d4tb00978a.pdf	Published version	4.54 MB		View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Romanazzo, S
dc.contributor.author	Zhu, Y
dc.contributor.author	Sheikh, R
dc.contributor.author	Lin, X
dc.contributor.author	Liu, H
dc.contributor.author	He, T-C
dc.contributor.author	Roohani, I https://orcid.org/0009-0000-3678-3455
dc.date.accessioned	2024-11-17T22:27:52Z
dc.date.available	2024-11-17T22:27:52Z
dc.date.issued	2024-10-02
dc.identifier.citation	J Mater Chem B, 2024, 12, (38), pp. 9575-9591
dc.identifier.issn	2050-750X
dc.identifier.issn	2050-7518
dc.identifier.uri	http://hdl.handle.net/10453/181935
dc.description.abstract	In this study, we have developed unique bioresorbable lithiated nanoparticles (LiCP, d50 = 20 nm), demonstrating a versatile material for bone repair and regeneration applications. The LiCPs are biocompatible even at the highest concentration tested (1000 μg mL-1) where bone marrow derived mesenchymal stem cells (BM-MSCs) maintained over 90% viability compared to the control. Notably, LiCP significantly enhanced the expression of osteogenic and angiogenic markers in vitro; collagen I, Runx2, angiogenin, and EGF increased by 8-fold, 8-fold, 9-fold, and 7.5-fold, respectively. Additionally, LiCP facilitated a marked improvement in tubulogenesis in endothelial cells across all tested concentrations. Remarkably, in an ectopic mouse model, LiCP induced mature bone formation, outperforming both the control group and non-lithiated nanoparticles. These findings establish lithiated nanoparticles as a highly promising material for advancing bone repair and regeneration therapies, offering dual benefits in osteogenesis and angiogenesis. The results lay the groundwork for future studies and potential clinical applications, where precise modulation of lithium release could tailor therapeutic outcomes to meet specific patient needs in bone and vascular tissue engineering.
dc.format	Electronic
dc.language	eng
dc.publisher	ROYAL SOC CHEMISTRY
dc.relation.ispartof	J Mater Chem B
dc.relation.isbasedon	10.1039/d4tb00978a
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0903 Biomedical Engineering
dc.subject.classification	3403 Macromolecular and materials chemistry
dc.subject.classification	4003 Biomedical engineering
dc.subject.classification	4004 Chemical engineering
dc.subject.mesh	Osteogenesis
dc.subject.mesh	Animals
dc.subject.mesh	Lithium
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Mice
dc.subject.mesh	Neovascularization, Physiologic
dc.subject.mesh	Mesenchymal Stem Cells
dc.subject.mesh	Humans
dc.subject.mesh	Biocompatible Materials
dc.subject.mesh	Particle Size
dc.subject.mesh	Cells, Cultured
dc.subject.mesh	Cells, Cultured
dc.subject.mesh	Mesenchymal Stem Cells
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Mice
dc.subject.mesh	Lithium
dc.subject.mesh	Biocompatible Materials
dc.subject.mesh	Osteogenesis
dc.subject.mesh	Neovascularization, Physiologic
dc.subject.mesh	Particle Size
dc.subject.mesh	Nanoparticles
dc.title	Highly disordered and resorbable lithiated nanoparticles with osteogenic and angiogenic properties.
dc.type	Journal Article
utslib.citation.volume	12
utslib.location.activity	England
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0903 Biomedical Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2024-11-17T22:27:50Z
pubs.issue	38
pubs.publication-status	Published online
pubs.volume	12
utslib.citation.issue	38

Abstract:

In this study, we have developed unique bioresorbable lithiated nanoparticles (LiCP, d50 = 20 nm), demonstrating a versatile material for bone repair and regeneration applications. The LiCPs are biocompatible even at the highest concentration tested (1000 μg mL-1) where bone marrow derived mesenchymal stem cells (BM-MSCs) maintained over 90% viability compared to the control. Notably, LiCP significantly enhanced the expression of osteogenic and angiogenic markers in vitro; collagen I, Runx2, angiogenin, and EGF increased by 8-fold, 8-fold, 9-fold, and 7.5-fold, respectively. Additionally, LiCP facilitated a marked improvement in tubulogenesis in endothelial cells across all tested concentrations. Remarkably, in an ectopic mouse model, LiCP induced mature bone formation, outperforming both the control group and non-lithiated nanoparticles. These findings establish lithiated nanoparticles as a highly promising material for advancing bone repair and regeneration therapies, offering dual benefits in osteogenesis and angiogenesis. The results lay the groundwork for future studies and potential clinical applications, where precise modulation of lithium release could tailor therapeutic outcomes to meet specific patient needs in bone and vascular tissue engineering.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/181935