Assessment of molecular and metabolic traits of a newly isolated Spirulina platensis BERC15 in a low-cost cultivation alternative for its use as functional food

Mehmood, MA; Amin, M; Haq, MAU; Shahid, A; Malik, S; Siddiqui, AJ; Wang, N; Zhu, H; Rasul, A; Chaudhry, AH; Nadeem, K; Boopathy, R; Zaman, QU; Musharraf, SG

Assessment of molecular and metabolic traits of a newly isolated Spirulina platensis BERC15 in a low-cost cultivation alternative for its use as functional food

Mehmood, MA Amin, M Haq, MAU Shahid, A Malik, S

Siddiqui, AJ Wang, N Zhu, H Rasul, A Chaudhry, AH Nadeem, K Boopathy, R Zaman, QU Musharraf, SG

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Publisher:: ELSEVIER
Publication Type:: Journal Article
Citation:: Bioresource Technology Reports, 2024, 26
Issue Date:: 2024-06-01

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Field	Value	Language
dc.contributor.author	Mehmood, MA
dc.contributor.author	Amin, M
dc.contributor.author	Haq, MAU
dc.contributor.author	Shahid, A
dc.contributor.author	Malik, S https://orcid.org/0000-0003-1373-9747
dc.contributor.author	Siddiqui, AJ
dc.contributor.author	Wang, N
dc.contributor.author	Zhu, H
dc.contributor.author	Rasul, A
dc.contributor.author	Chaudhry, AH
dc.contributor.author	Nadeem, K
dc.contributor.author	Boopathy, R
dc.contributor.author	Zaman, QU
dc.contributor.author	Musharraf, SG
dc.date.accessioned	2024-11-22T02:22:40Z
dc.date.available	2024-11-22T02:22:40Z
dc.date.issued	2024-06-01
dc.identifier.citation	Bioresource Technology Reports, 2024, 26
dc.identifier.issn	2589-014X
dc.identifier.issn	2589-014X
dc.identifier.uri	http://hdl.handle.net/10453/182052
dc.description.abstract	Commercial cultivation of Spirulina relies on expensive chemicals. This study aimed to optimize low-cost cultivation media for upscaling of the Spirulina cultivation for food applications. Here, low-cost nitrogen source resulted in 3 gL−1 of biomass while outdoor pilot-scale cultivation produced 6.5–9.6 g m−2day−1 of biomass. The growth media prepared in underground water (UGW) using commercial-grade chemicals (UGW + CC) was found to be the most suitable low-cost alternative media which produced 2.3 ± 0.28 gL−1 of biomass containing 56 ± 1.22 % proteins, 22 ± 1.88 % carbohydrates, and 12 ± 2.52 % lipids. GC–MS-based metabolomic analysis implied that only four metabolites were either down or upregulated out of 50 detected metabolites. The Hep G2 cancer cell line-based study showed 15-fold higher free radical scavenging activity in UGW + CC grown cells compared to control. This study provides a basis for process optimization towards commercial-scale cultivation of Spirulina using small and medium enterprise mode.
dc.language	English
dc.publisher	ELSEVIER
dc.relation.ispartof	Bioresource Technology Reports
dc.relation.isbasedon	10.1016/j.biteb.2024.101816
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	4011 Environmental engineering
dc.subject.classification	4103 Environmental biotechnology
dc.title	Assessment of molecular and metabolic traits of a newly isolated Spirulina platensis BERC15 in a low-cost cultivation alternative for its use as functional food
dc.type	Journal Article
utslib.citation.volume	26
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Climate Change Cluster Research Strength (C3)
utslib.copyright.status	closed_access	*
dc.date.updated	2024-11-22T02:22:38Z
pubs.publication-status	Published
pubs.volume	26

Abstract:

Commercial cultivation of Spirulina relies on expensive chemicals. This study aimed to optimize low-cost cultivation media for upscaling of the Spirulina cultivation for food applications. Here, low-cost nitrogen source resulted in 3 gL−1 of biomass while outdoor pilot-scale cultivation produced 6.5–9.6 g m−2day−1 of biomass. The growth media prepared in underground water (UGW) using commercial-grade chemicals (UGW + CC) was found to be the most suitable low-cost alternative media which produced 2.3 ± 0.28 gL−1 of biomass containing 56 ± 1.22 % proteins, 22 ± 1.88 % carbohydrates, and 12 ± 2.52 % lipids. GC–MS-based metabolomic analysis implied that only four metabolites were either down or upregulated out of 50 detected metabolites. The Hep G2 cancer cell line-based study showed 15-fold higher free radical scavenging activity in UGW + CC grown cells compared to control. This study provides a basis for process optimization towards commercial-scale cultivation of Spirulina using small and medium enterprise mode.

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http://hdl.handle.net/10453/182052