Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival.
Morra, A
Schreurs, MAC
Andrulis, IL
Anton-Culver, H
Augustinsson, A
Beckmann, MW
Behrens, S
Bojesen, SE
Bolla, MK
Brauch, H
Broeks, A
Patel, AV
Peterlongo, P
Phillips, K-A
Plaseska-Karanfilska, D
Polley, EC
Presneau, N
Pylkäs, K
Rack, B
Radice, P
Rashid, MU
Southey, MC
Rhenius, V
Robson, M
Romero, A
Saloustros, E
Sawyer, EJ
Schmutzler, RK
Schuetze, S
Scott, C
Shah, M
Smichkoska, S
Tapper, WJ
Teras, LR
Tollenaar, RAEM
Tomczyk, K
Tomlinson, I
Troester, MA
Vachon, CM
van Veen, EM
Wang, Q
Buys, SS
Wendt, C
Wildiers, H
Winqvist, R
Ziogas, A
Hall, P
Pharoah, PDP
Adank, MA
Hollestelle, A
Schmidt, MK
Hooning, MJ
Camp, NJ
Castelao, JE
Cessna, MH
Chang-Claude, J
Chung, WK
NBCS Collaborators,
Colonna, SV
Couch, FJ
Cox, A
Cross, SS
Czene, K
Daly, MB
Dennis, J
Devilee, P
Dörk, T
Dunning, AM
Dwek, M
Easton, DF
Eccles, DM
Eriksson, M
Evans, DG
Fasching, PA
Fehm, TN
Figueroa, JD
Flyger, H
Gabrielson, M
Gago-Dominguez, M
García-Closas, M
García-Sáenz, JA
Genkinger, J
Grassmann, F
Gündert, M
Hahnen, E
Haiman, CA
Hamann, U
Harrington, PA
Hartikainen, JM
Hoppe, R
Hopper, JL
Houlston, RS
Howell, A
ABCTB Investigators,
kConFab Investigators,
Jakubowska, A
Janni, W
Jernström, H
John, EM
Johnson, N
Jones, ME
Kristensen, VN
Kurian, AW
Lambrechts, D
Le Marchand, L
Lindblom, A
Lubiński, J
Lux, MP
Mannermaa, A
Mavroudis, D
Mulligan, AM
Muranen, TA
Nevanlinna, H
Nevelsteen, I
Neven, P
Newman, WG
Obi, N
Offit, K
Olshan, AF
Park-Simon, T-W
- Publisher:
- Wiley
- Publication Type:
- Journal Article
- Citation:
- Cancer Med, 2023, 12, (15), pp. 16142-16162
- Issue Date:
- 2023-08
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Morra, A | |
dc.contributor.author | Schreurs, MAC | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Anton-Culver, H | |
dc.contributor.author | Augustinsson, A | |
dc.contributor.author | Beckmann, MW | |
dc.contributor.author | Behrens, S | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Brauch, H | |
dc.contributor.author | Broeks, A | |
dc.contributor.author | Patel, AV | |
dc.contributor.author | Peterlongo, P | |
dc.contributor.author | Phillips, K-A | |
dc.contributor.author | Plaseska-Karanfilska, D | |
dc.contributor.author | Polley, EC | |
dc.contributor.author | Presneau, N | |
dc.contributor.author | Pylkäs, K | |
dc.contributor.author | Rack, B | |
dc.contributor.author | Radice, P | |
dc.contributor.author | Rashid, MU | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Rhenius, V | |
dc.contributor.author | Robson, M | |
dc.contributor.author | Romero, A | |
dc.contributor.author | Saloustros, E | |
dc.contributor.author | Sawyer, EJ | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Schuetze, S | |
dc.contributor.author | Scott, C | |
dc.contributor.author | Shah, M | |
dc.contributor.author | Smichkoska, S | |
dc.contributor.author | Tapper, WJ | |
dc.contributor.author | Teras, LR | |
dc.contributor.author | Tollenaar, RAEM | |
dc.contributor.author | Tomczyk, K | |
dc.contributor.author | Tomlinson, I | |
dc.contributor.author | Troester, MA | |
dc.contributor.author | Vachon, CM | |
dc.contributor.author | van Veen, EM | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Buys, SS | |
dc.contributor.author | Wendt, C | |
dc.contributor.author | Wildiers, H | |
dc.contributor.author | Winqvist, R | |
dc.contributor.author | Ziogas, A | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Adank, MA | |
dc.contributor.author | Hollestelle, A | |
dc.contributor.author | Schmidt, MK | |
dc.contributor.author | Hooning, MJ | |
dc.contributor.author | Camp, NJ | |
dc.contributor.author | Castelao, JE | |
dc.contributor.author | Cessna, MH | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Chung, WK | |
dc.contributor.author | NBCS Collaborators, | |
dc.contributor.author | Colonna, SV | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Cox, A | |
dc.contributor.author | Cross, SS | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Daly, MB | |
dc.contributor.author | Dennis, J | |
dc.contributor.author | Devilee, P | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Dwek, M | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Eccles, DM | |
dc.contributor.author | Eriksson, M | |
dc.contributor.author | Evans, DG | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Fehm, TN | |
dc.contributor.author | Figueroa, JD | |
dc.contributor.author | Flyger, H | |
dc.contributor.author | Gabrielson, M | |
dc.contributor.author | Gago-Dominguez, M | |
dc.contributor.author | García-Closas, M | |
dc.contributor.author | García-Sáenz, JA | |
dc.contributor.author | Genkinger, J | |
dc.contributor.author | Grassmann, F | |
dc.contributor.author | Gündert, M | |
dc.contributor.author | Hahnen, E | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Harrington, PA | |
dc.contributor.author | Hartikainen, JM | |
dc.contributor.author | Hoppe, R | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Houlston, RS | |
dc.contributor.author | Howell, A | |
dc.contributor.author | ABCTB Investigators, | |
dc.contributor.author | kConFab Investigators, | |
dc.contributor.author | Jakubowska, A | |
dc.contributor.author | Janni, W | |
dc.contributor.author | Jernström, H | |
dc.contributor.author | John, EM | |
dc.contributor.author | Johnson, N | |
dc.contributor.author | Jones, ME | |
dc.contributor.author | Kristensen, VN | |
dc.contributor.author | Kurian, AW | |
dc.contributor.author | Lambrechts, D | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Lindblom, A | |
dc.contributor.author | Lubiński, J | |
dc.contributor.author | Lux, MP | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Mavroudis, D | |
dc.contributor.author | Mulligan, AM | |
dc.contributor.author | Muranen, TA | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Nevelsteen, I | |
dc.contributor.author | Neven, P | |
dc.contributor.author | Newman, WG | |
dc.contributor.author | Obi, N | |
dc.contributor.author | Offit, K | |
dc.contributor.author | Olshan, AF | |
dc.contributor.author | Park-Simon, T-W | |
dc.date.accessioned | 2024-12-04T06:35:51Z | |
dc.date.available | 2023-06-03 | |
dc.date.available | 2024-12-04T06:35:51Z | |
dc.date.issued | 2023-08 | |
dc.identifier.citation | Cancer Med, 2023, 12, (15), pp. 16142-16162 | |
dc.identifier.issn | 2045-7634 | |
dc.identifier.issn | 2045-7634 | |
dc.identifier.uri | http://hdl.handle.net/10453/182340 | |
dc.description.abstract | BACKGROUND: Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers. AIM: To assessed the associations of CHEK2 c.1100delC, radiotherapy, and systemic treatment with CBC risk and BCSS. METHODS: Analyses were based on 82,701 women diagnosed with a first primary invasive BC including 963 CHEK2 c.1100delC carriers; median follow-up was 9.1 years. Differential associations with treatment by CHEK2 c.1100delC status were tested by including interaction terms in a multivariable Cox regression model. A multi-state model was used for further insight into the relation between CHEK2 c.1100delC status, treatment, CBC risk and death. RESULTS: There was no evidence for differential associations of therapy with CBC risk by CHEK2 c.1100delC status. The strongest association with reduced CBC risk was observed for the combination of chemotherapy and endocrine therapy [HR (95% CI): 0.66 (0.55-0.78)]. No association was observed with radiotherapy. Results from the multi-state model showed shorter BCSS for CHEK2 c.1100delC carriers versus non-carriers also after accounting for CBC occurrence [HR (95% CI): 1.30 (1.09-1.56)]. CONCLUSION: Systemic therapy was associated with reduced CBC risk irrespective of CHEK2 c.1100delC status. Moreover, CHEK2 c.1100delC carriers had shorter BCSS, which appears not to be fully explained by their CBC risk. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Wiley | |
dc.relation.ispartof | Cancer Med | |
dc.relation.isbasedon | 10.1002/cam4.6272 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 0601 Biochemistry and Cell Biology, 1112 Oncology and Carcinogenesis | |
dc.subject.classification | 3211 Oncology and carcinogenesis | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Breast Neoplasms | |
dc.subject.mesh | Checkpoint Kinase 2 | |
dc.subject.mesh | Genetic Predisposition to Disease | |
dc.subject.mesh | Germ-Line Mutation | |
dc.subject.mesh | Heterozygote | |
dc.subject.mesh | Proportional Hazards Models | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Breast Neoplasms | |
dc.subject.mesh | Genetic Predisposition to Disease | |
dc.subject.mesh | Proportional Hazards Models | |
dc.subject.mesh | Heterozygote | |
dc.subject.mesh | Germ-Line Mutation | |
dc.subject.mesh | Female | |
dc.subject.mesh | Checkpoint Kinase 2 | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Breast Neoplasms | |
dc.subject.mesh | Checkpoint Kinase 2 | |
dc.subject.mesh | Genetic Predisposition to Disease | |
dc.subject.mesh | Germ-Line Mutation | |
dc.subject.mesh | Heterozygote | |
dc.subject.mesh | Proportional Hazards Models | |
dc.title | Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival. | |
dc.type | Journal Article | |
utslib.citation.volume | 12 | |
utslib.location.activity | United States | |
utslib.for | 0601 Biochemistry and Cell Biology | |
utslib.for | 1112 Oncology and Carcinogenesis | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science/School of Life Sciences | |
pubs.organisational-group | University of Technology Sydney/UTS Groups | |
pubs.organisational-group | University of Technology Sydney/UTS Groups/Centre for Health Technologies (CHT) | |
utslib.copyright.status | open_access | * |
dc.rights.license | This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2024-12-04T06:35:48Z | |
pubs.issue | 15 | |
pubs.publication-status | Published | |
pubs.volume | 12 | |
utslib.citation.issue | 15 |
Abstract:
BACKGROUND: Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers. AIM: To assessed the associations of CHEK2 c.1100delC, radiotherapy, and systemic treatment with CBC risk and BCSS. METHODS: Analyses were based on 82,701 women diagnosed with a first primary invasive BC including 963 CHEK2 c.1100delC carriers; median follow-up was 9.1 years. Differential associations with treatment by CHEK2 c.1100delC status were tested by including interaction terms in a multivariable Cox regression model. A multi-state model was used for further insight into the relation between CHEK2 c.1100delC status, treatment, CBC risk and death. RESULTS: There was no evidence for differential associations of therapy with CBC risk by CHEK2 c.1100delC status. The strongest association with reduced CBC risk was observed for the combination of chemotherapy and endocrine therapy [HR (95% CI): 0.66 (0.55-0.78)]. No association was observed with radiotherapy. Results from the multi-state model showed shorter BCSS for CHEK2 c.1100delC carriers versus non-carriers also after accounting for CBC occurrence [HR (95% CI): 1.30 (1.09-1.56)]. CONCLUSION: Systemic therapy was associated with reduced CBC risk irrespective of CHEK2 c.1100delC status. Moreover, CHEK2 c.1100delC carriers had shorter BCSS, which appears not to be fully explained by their CBC risk.
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