The detection of human papillomavirus in head and neck cancers

Deutsch, Fiona Therese

The detection of human papillomavirus in head and neck cancers

Deutsch, Fiona Therese

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Publication Type:: Thesis
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Deutsch, Fiona Therese
dc.date.accessioned	2024-12-05T02:34:55Z
dc.date.available	2024-12-05T02:34:55Z
dc.date.issued	2023
dc.identifier.uri	http://hdl.handle.net/10453/182363
dc.description	University of Technology Sydney. Faculty of Engineering and Information Technology.	en_US.UTF-8
dc.description.abstract	Head and neck cancer (HNC) ranks as the sixth most common cancer globally, with 5-year survival rates below 50% for late-stage diagnoses. Recent years have seen a surge in cases linked to the human papillomavirus (HPV), particularly HPV16, which is implicated in over 85% of oropharyngeal cancers (OPC). Given the distinct epidemiological and molecular profiles of HPV-related OPC, precise diagnostics for active HPV are crucial. This doctoral research developed a multiplex assay for HPV16 RNA oncogenes E6 and E7 detection in saliva from OPC patients in Sydney, demonstrating comparable efficiency to traditional methods and a reliable detection threshold. The research extended into bioinformatics due to COVID-19, analysing HNC trends in Southeast Asia using data from the Ho Chi Minh Cancer Registry (1996-2015). The study identified rising incidence rates of oropharyngeal and oral cancers in Vietnam, with nasopharyngeal cancer being disproportionately high compared to other Southeast Asian countries. Interestingly, the age-standardised rate (ASR) for oropharyngeal cancer matched global figures, underscoring the need for expanded HPV vaccination and screening strategies in Vietnam. This work not only introduces a novel non-invasive diagnostic tool but also provides the first comprehensive characterisation of HNC epidemiology in Ho Chi Minh City, highlighting significant subtype-specific trends.	en_US.UTF-8
dc.format	Thesis (PhD)
dc.language.iso	en_US	en_US.UTF-8
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/182363/1/thesis.pdf
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	© 2023 Fiona Therese Deutsch
dc.rights	au.edu.uts.lib/cph
dc.title	The detection of human papillomavirus in head and neck cancers	en_US.UTF-8
dc.type	Thesis
utslib.copyright.status	open_access	*

Abstract:

Head and neck cancer (HNC) ranks as the sixth most common cancer globally, with 5-year survival rates below 50% for late-stage diagnoses. Recent years have seen a surge in cases linked to the human papillomavirus (HPV), particularly HPV16, which is implicated in over 85% of oropharyngeal cancers (OPC). Given the distinct epidemiological and molecular profiles of HPV-related OPC, precise diagnostics for active HPV are crucial. This doctoral research developed a multiplex assay for HPV16 RNA oncogenes E6 and E7 detection in saliva from OPC patients in Sydney, demonstrating comparable efficiency to traditional methods and a reliable detection threshold. The research extended into bioinformatics due to COVID-19, analysing HNC trends in Southeast Asia using data from the Ho Chi Minh Cancer Registry (1996-2015). The study identified rising incidence rates of oropharyngeal and oral cancers in Vietnam, with nasopharyngeal cancer being disproportionately high compared to other Southeast Asian countries. Interestingly, the age-standardised rate (ASR) for oropharyngeal cancer matched global figures, underscoring the need for expanded HPV vaccination and screening strategies in Vietnam. This work not only introduces a novel non-invasive diagnostic tool but also provides the first comprehensive characterisation of HNC epidemiology in Ho Chi Minh City, highlighting significant subtype-specific trends.

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http://hdl.handle.net/10453/182363