The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses.

Quinteros, SL; Snyder, NW; Chatoff, A; Ryan, F; O'Brien, B; Donnelly, S

The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses.

Quinteros, SL Snyder, NW Chatoff, A Ryan, F O'Brien, B

Donnelly, S

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Eur J Immunol, 2024, 54, (6), pp. e2350643
Issue Date:: 2024-06

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Field	Value	Language
dc.contributor.author	Quinteros, SL
dc.contributor.author	Snyder, NW
dc.contributor.author	Chatoff, A
dc.contributor.author	Ryan, F
dc.contributor.author	O'Brien, B https://orcid.org/0000-0001-5887-2424
dc.contributor.author	Donnelly, S https://orcid.org/0000-0003-2005-3698
dc.date.accessioned	2024-12-20T04:28:48Z
dc.date.available	2024-03-21
dc.date.available	2024-12-20T04:28:48Z
dc.date.issued	2024-06
dc.identifier.citation	Eur J Immunol, 2024, 54, (6), pp. e2350643
dc.identifier.issn	0014-2980
dc.identifier.issn	1521-4141
dc.identifier.uri	http://hdl.handle.net/10453/182731
dc.description.abstract	We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation	http://purl.org/au-research/grants/nhmrc/1142006
dc.relation	Juvenile Diabetes Research Foundation1-INO-2019-785-S-B
dc.relation.ispartof	Eur J Immunol
dc.relation.isbasedon	10.1002/eji.202350643
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1107 Immunology
dc.subject.classification	Immunology
dc.subject.classification	3204 Immunology
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Cytokines
dc.subject.mesh	Diabetes Mellitus, Type 1
dc.subject.mesh	Glycolysis
dc.subject.mesh	Histones
dc.subject.mesh	Inflammation
dc.subject.mesh	Macrophages
dc.subject.mesh	Mice, Inbred BALB C
dc.subject.mesh	Mice, Inbred NOD
dc.subject.mesh	Phenotype
dc.subject.mesh	Helminth Proteins
dc.subject.mesh	Macrophages
dc.subject.mesh	Animals
dc.subject.mesh	Mice, Inbred BALB C
dc.subject.mesh	Mice, Inbred NOD
dc.subject.mesh	Mice
dc.subject.mesh	Diabetes Mellitus, Type 1
dc.subject.mesh	Inflammation
dc.subject.mesh	Helminth Proteins
dc.subject.mesh	Histones
dc.subject.mesh	Cytokines
dc.subject.mesh	Glycolysis
dc.subject.mesh	Phenotype
dc.subject.mesh	Animals
dc.subject.mesh	Macrophages
dc.subject.mesh	Mice
dc.subject.mesh	Mice, Inbred NOD
dc.subject.mesh	Mice, Inbred BALB C
dc.subject.mesh	Diabetes Mellitus, Type 1
dc.subject.mesh	Cytokines
dc.subject.mesh	Phenotype
dc.subject.mesh	Glycolysis
dc.subject.mesh	Histones
dc.subject.mesh	Inflammation
dc.title	The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses.
dc.type	Journal Article
utslib.citation.volume	54
utslib.location.activity	Germany
utslib.for	1107 Immunology
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Health Technologies (CHT)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Australian Institute for Microbiology & Infection (AIMI)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Australian Institute for Microbiology & Infection (AIMI)/Australian Institute for Microbiology & Infection (AIMI) Associate Members
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated	2024-12-20T04:28:46Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	54
utslib.citation.issue	6

Abstract:

We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.

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http://hdl.handle.net/10453/182731