A gelatin/acrylamide-based hydrogel for smart drug release monitoring and radiation-induced wound repair in breast cancer.

Su, Y; Xu, J; Liu, W; Shu, Y; Ma, H; Cheng, YY; Liu, Y; Pan, B; Song, K

A gelatin/acrylamide-based hydrogel for smart drug release monitoring and radiation-induced wound repair in breast cancer.

Su, Y Xu, J Liu, W Shu, Y Ma, H Cheng, YY Liu, Y Pan, B Song, K

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Int J Biol Macromol, 2024, 283, (Pt 4), pp. 137845
Issue Date:: 2024-12

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Field	Value	Language
dc.contributor.author	Su, Y
dc.contributor.author	Xu, J
dc.contributor.author	Liu, W
dc.contributor.author	Shu, Y
dc.contributor.author	Ma, H
dc.contributor.author	Cheng, YY
dc.contributor.author	Liu, Y
dc.contributor.author	Pan, B
dc.contributor.author	Song, K
dc.date.accessioned	2025-01-13T00:08:54Z
dc.date.available	2024-11-17
dc.date.available	2025-01-13T00:08:54Z
dc.date.issued	2024-12
dc.identifier.citation	Int J Biol Macromol, 2024, 283, (Pt 4), pp. 137845
dc.identifier.issn	0141-8130
dc.identifier.issn	1879-0003
dc.identifier.uri	http://hdl.handle.net/10453/183289
dc.description.abstract	Radiotherapy is a common local treatment for breast cancer, and while it is effective in targeting tumor cells, it inevitably causes significant side effects. These include excessive production of reactive oxygen species (ROS), repeated inflammatory, and severe skin ulceration, all of which can hinder the wound healing process. As a result, there is a pressing need for multifunctional medical dressings that can support wound repair following radiotherapy. In this study, we introduced a novel double-network interpenetrating hydrogel (GEMC), which combined gelatin grafted dopamine (GEDA), acrylamide, nano-clay (NC), and curcumin loaded nanoparticles (CCNPs). Unlike traditional single-function hydrogels, the GEMC hydrogel offered a combination of antioxidant properties, tissue adhesion, and real time drug tracking, effectively addressing the multifaceted challenges of wound healing after radiotherapy. The GEMC hydrogel exhibited impressive antioxidant activity and superior mechanical properties, which collectively improve the support and protection of wounded surfaces. Furthermore, GEMC promoted skin regeneration, angiogenesis and reduced inflammatory in a mouse model of radiotherapy-induced skin ulceration. These results highlight the hydrogel's potential to accelerate would healing and enhance the effectiveness of post-radiotherapy wound care, providing a promising new approach to improving the quality of skin recovery following radiotherapy.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Int J Biol Macromol
dc.relation.isbasedon	10.1016/j.ijbiomac.2024.137845
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology
dc.subject.classification	Polymers
dc.subject.classification	3101 Biochemistry and cell biology
dc.subject.mesh	Hydrogels
dc.subject.mesh	Gelatin
dc.subject.mesh	Wound Healing
dc.subject.mesh	Animals
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Female
dc.subject.mesh	Mice
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Acrylamide
dc.subject.mesh	Curcumin
dc.subject.mesh	Humans
dc.subject.mesh	Antioxidants
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Mice
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Acrylamide
dc.subject.mesh	Curcumin
dc.subject.mesh	Gelatin
dc.subject.mesh	Hydrogels
dc.subject.mesh	Antioxidants
dc.subject.mesh	Wound Healing
dc.subject.mesh	Female
dc.subject.mesh	Nanoparticles
dc.subject.mesh	Drug Liberation
dc.title	A gelatin/acrylamide-based hydrogel for smart drug release monitoring and radiation-induced wound repair in breast cancer.
dc.type	Journal Article
utslib.citation.volume	283
utslib.location.activity	Netherlands
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Institute of Biomedical Materials and Devices (IBMD)
utslib.copyright.status	closed_access	*
dc.date.updated	2025-01-13T00:08:51Z
pubs.issue	Pt 4
pubs.publication-status	Published
pubs.volume	283
utslib.citation.issue	Pt 4

Abstract:

Radiotherapy is a common local treatment for breast cancer, and while it is effective in targeting tumor cells, it inevitably causes significant side effects. These include excessive production of reactive oxygen species (ROS), repeated inflammatory, and severe skin ulceration, all of which can hinder the wound healing process. As a result, there is a pressing need for multifunctional medical dressings that can support wound repair following radiotherapy. In this study, we introduced a novel double-network interpenetrating hydrogel (GEMC), which combined gelatin grafted dopamine (GEDA), acrylamide, nano-clay (NC), and curcumin loaded nanoparticles (CCNPs). Unlike traditional single-function hydrogels, the GEMC hydrogel offered a combination of antioxidant properties, tissue adhesion, and real time drug tracking, effectively addressing the multifaceted challenges of wound healing after radiotherapy. The GEMC hydrogel exhibited impressive antioxidant activity and superior mechanical properties, which collectively improve the support and protection of wounded surfaces. Furthermore, GEMC promoted skin regeneration, angiogenesis and reduced inflammatory in a mouse model of radiotherapy-induced skin ulceration. These results highlight the hydrogel's potential to accelerate would healing and enhance the effectiveness of post-radiotherapy wound care, providing a promising new approach to improving the quality of skin recovery following radiotherapy.

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http://hdl.handle.net/10453/183289