A novel biological antibacterial polyvinyl alcohol/polyionic liquid hydrogel for wound dressing.

Liu, W; Wang, H; Liu, J; Cheng, YY; Guan, Y; Song, K

A novel biological antibacterial polyvinyl alcohol/polyionic liquid hydrogel for wound dressing.

Liu, W Wang, H Liu, J Cheng, YY Guan, Y Song, K

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Publisher:: SAGE Publications
Publication Type:: Journal Article
Citation:: J Biomater Appl, 2024, 39, (4), pp. 355-366
Issue Date:: 2024-10

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Field	Value	Language
dc.contributor.author	Liu, W
dc.contributor.author	Wang, H
dc.contributor.author	Liu, J
dc.contributor.author	Cheng, YY
dc.contributor.author	Guan, Y
dc.contributor.author	Song, K
dc.date.accessioned	2025-01-13T00:13:46Z
dc.date.available	2025-01-13T00:13:46Z
dc.date.issued	2024-10
dc.identifier.citation	J Biomater Appl, 2024, 39, (4), pp. 355-366
dc.identifier.issn	0885-3282
dc.identifier.issn	1530-8022
dc.identifier.uri	http://hdl.handle.net/10453/183292
dc.description.abstract	The release of antibiotics or anions by traditional bacteriostatic agents led to the development of bacterial drug resistance and environmental pollution. Ionic liquids (ILs) have become important choices for antibacterial agents because of their excellent physical, chemical and biological properties. In this paper, the bioactivities of 1-vinyl-3-butylimidazolium chloride ([VBIM]Cl, IL) and poly (1-vinyl-3-butylimidazolium chloride) (P[VBIM]Cl, PIL) were evaluated, and the potential antibacterial material was used to synthesize hydrogels. Using the colony formation assay and the Oxford cup method, antibacterial effect of IL and PIL were tested. Cell-Counting-Kit-8 (CCK-8) experiments were used to study the IC50 (half maximal inhibitory concentration) values of IL and showed 1.47 mg/mL, 0.35 mg/mL and 0.33 mg/mL at 24 h, 48 h and 72 h, respectively. The IC50 value of PIL were 12.15 μg/mL, 12.06 μg/mL and 11.76 μg/mL at 24 h, 48 h and 72 h, respectively. The PIL is further crosslinked with polyvinyl alcohol (PVA) to form a novel hydrogel through freeze-thaw cycles. The newly fabricated hydrogel exhibited a high water content, excellent water absorption properties and outstanding mechanical performance. Using the colony formation assay and the inhibition zone assay, the hydrogels exhibited favorable antibacterial effects (against E.coli and S.aureus) such that nearly 100% of the bacteria were killed in liquid medium while cultivating with H4 (synthesized by 0.5 g PIL and 1g PVA). In addition, the cytotoxicity of PIL was significantly reduced through hydrogen bond crosslinking. H4 showed the highest antibacterial activity and a good biocompatibility. The results indicated that the PVA&PIL hydrogels had great potential for wound dressing.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SAGE Publications
dc.relation.ispartof	J Biomater Appl
dc.relation.isbasedon	10.1177/08853282241264095
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0903 Biomedical Engineering, 0912 Materials Engineering
dc.subject.classification	Biomedical Engineering
dc.subject.classification	4003 Biomedical engineering
dc.subject.classification	4016 Materials engineering
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Polyvinyl Alcohol
dc.subject.mesh	Ionic Liquids
dc.subject.mesh	Hydrogels
dc.subject.mesh	Bandages
dc.subject.mesh	Escherichia coli
dc.subject.mesh	Staphylococcus aureus
dc.subject.mesh	Humans
dc.subject.mesh	Wound Healing
dc.subject.mesh	Animals
dc.subject.mesh	Microbial Sensitivity Tests
dc.subject.mesh	Mice
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Mice
dc.subject.mesh	Escherichia coli
dc.subject.mesh	Staphylococcus aureus
dc.subject.mesh	Polyvinyl Alcohol
dc.subject.mesh	Hydrogels
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Microbial Sensitivity Tests
dc.subject.mesh	Bandages
dc.subject.mesh	Wound Healing
dc.subject.mesh	Ionic Liquids
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Polyvinyl Alcohol
dc.subject.mesh	Ionic Liquids
dc.subject.mesh	Hydrogels
dc.subject.mesh	Bandages
dc.subject.mesh	Escherichia coli
dc.subject.mesh	Staphylococcus aureus
dc.subject.mesh	Humans
dc.subject.mesh	Wound Healing
dc.subject.mesh	Animals
dc.subject.mesh	Microbial Sensitivity Tests
dc.subject.mesh	Mice
dc.title	A novel biological antibacterial polyvinyl alcohol/polyionic liquid hydrogel for wound dressing.
dc.type	Journal Article
utslib.citation.volume	39
utslib.location.activity	England
utslib.for	0903 Biomedical Engineering
utslib.for	0912 Materials Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Institute of Biomedical Materials and Devices (IBMD)
utslib.copyright.status	closed_access	*
dc.date.updated	2025-01-13T00:13:44Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	39
utslib.citation.issue	4

Abstract:

The release of antibiotics or anions by traditional bacteriostatic agents led to the development of bacterial drug resistance and environmental pollution. Ionic liquids (ILs) have become important choices for antibacterial agents because of their excellent physical, chemical and biological properties. In this paper, the bioactivities of 1-vinyl-3-butylimidazolium chloride ([VBIM]Cl, IL) and poly (1-vinyl-3-butylimidazolium chloride) (P[VBIM]Cl, PIL) were evaluated, and the potential antibacterial material was used to synthesize hydrogels. Using the colony formation assay and the Oxford cup method, antibacterial effect of IL and PIL were tested. Cell-Counting-Kit-8 (CCK-8) experiments were used to study the IC50 (half maximal inhibitory concentration) values of IL and showed 1.47 mg/mL, 0.35 mg/mL and 0.33 mg/mL at 24 h, 48 h and 72 h, respectively. The IC50 value of PIL were 12.15 μg/mL, 12.06 μg/mL and 11.76 μg/mL at 24 h, 48 h and 72 h, respectively. The PIL is further crosslinked with polyvinyl alcohol (PVA) to form a novel hydrogel through freeze-thaw cycles. The newly fabricated hydrogel exhibited a high water content, excellent water absorption properties and outstanding mechanical performance. Using the colony formation assay and the inhibition zone assay, the hydrogels exhibited favorable antibacterial effects (against E.coli and S.aureus) such that nearly 100% of the bacteria were killed in liquid medium while cultivating with H4 (synthesized by 0.5 g PIL and 1g PVA). In addition, the cytotoxicity of PIL was significantly reduced through hydrogen bond crosslinking. H4 showed the highest antibacterial activity and a good biocompatibility. The results indicated that the PVA&PIL hydrogels had great potential for wound dressing.

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http://hdl.handle.net/10453/183292