Association between caesarean section delivery and obesity in childhood: a longitudinal cohort study in Ireland.

Masukume, G; McCarthy, FP; Baker, PN; Kenny, LC; Morton, SM; Murray, DM; Hourihane, JO; Khashan, AS

Association between caesarean section delivery and obesity in childhood: a longitudinal cohort study in Ireland.

Masukume, G McCarthy, FP Baker, PN Kenny, LC Morton, SM Murray, DM Hourihane, JO Khashan, AS

Permalink

Publisher:: BMJ PUBLISHING GROUP
Publication Type:: Journal Article
Citation:: BMJ Open, 2019, 9, (3), pp. e025051
Issue Date:: 2019-03-15

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published versionAdobe PDF (552.84 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Masukume, G
dc.contributor.author	McCarthy, FP
dc.contributor.author	Baker, PN
dc.contributor.author	Kenny, LC
dc.contributor.author	Morton, SM
dc.contributor.author	Murray, DM
dc.contributor.author	Hourihane, JO
dc.contributor.author	Khashan, AS
dc.date.accessioned	2025-01-13T02:58:15Z
dc.date.available	2025-01-13T02:58:15Z
dc.date.issued	2019-03-15
dc.identifier.citation	BMJ Open, 2019, 9, (3), pp. e025051
dc.identifier.issn	2044-6055
dc.identifier.issn	2044-6055
dc.identifier.uri	http://hdl.handle.net/10453/183326
dc.description.abstract	OBJECTIVES: To investigate the association between caesarean section (CS) birth and body fat percentage (BF%), body mass index (BMI) and being overweight or obese in early childhood. DESIGN: Prospective longitudinal cohort study. SETTING: Babies After Screening for Pregnancy Endpoints: Evaluating the Longitudinal Impact on Neurological and Nutritional Endpoints cohort. PARTICIPANTS: Infants born to mothers recruited from the Screening for Pregnancy Endpoints study, Cork University Maternity Hospital between November 2007 and February 2011. OUTCOME MEASURE: Overweight or obese defined according to the International Obesity Task Force criteria. RESULTS: Of the 1305 infants, 362 (27.8%) were delivered by CS. On regression analysis, BF% at 2 months did not differ significantly by delivery mode. Infants born by CS had a higher mean BMI at 6 months compared with those born vaginally (adjusted mean difference=0.24; 95% CI 0.06 to 0.41, p value=0.009). At 2 years, no difference was seen across the exposure groups in the risk of being overweight or obese. At 5 years, the association between prelabour CS and the risk of overweight or obesity was not statistically significant (adjusted relative risk ratio, aRRR=1.37; 95% CI 0.69 to 2.69) and the association remained statistically nonsignificant when children who were macrosomic at birth were excluded from the model (aRRR=0.86; 95% CI 0.36 to 2.08). CONCLUSION: At 6 months of age, children born by CS had a significantly higher BMI but this did not persist into future childhood. There was no evidence to support an association between mode of delivery and long-term risk of obesity in the child.
dc.format	Electronic
dc.language	eng
dc.publisher	BMJ PUBLISHING GROUP
dc.relation.ispartof	BMJ Open
dc.relation.isbasedon	10.1136/bmjopen-2018-025051
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences, 1117 Public Health and Health Services, 1199 Other Medical and Health Sciences
dc.subject.classification	32 Biomedical and clinical sciences
dc.subject.classification	42 Health sciences
dc.subject.classification	52 Psychology
dc.subject.mesh	Birth Weight
dc.subject.mesh	Body Mass Index
dc.subject.mesh	Cesarean Section
dc.subject.mesh	Child
dc.subject.mesh	Child, Preschool
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Delivery, Obstetric
dc.subject.mesh	Humans
dc.subject.mesh	Infant
dc.subject.mesh	Ireland
dc.subject.mesh	Longitudinal Studies
dc.subject.mesh	Male
dc.subject.mesh	Pediatric Obesity
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Risk Factors
dc.subject.mesh	Humans
dc.subject.mesh	Birth Weight
dc.subject.mesh	Body Mass Index
dc.subject.mesh	Delivery, Obstetric
dc.subject.mesh	Cesarean Section
dc.subject.mesh	Risk Factors
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Longitudinal Studies
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Child
dc.subject.mesh	Child, Preschool
dc.subject.mesh	Infant
dc.subject.mesh	Ireland
dc.subject.mesh	Male
dc.subject.mesh	Pediatric Obesity
dc.subject.mesh	Birth Weight
dc.subject.mesh	Body Mass Index
dc.subject.mesh	Cesarean Section
dc.subject.mesh	Child
dc.subject.mesh	Child, Preschool
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Delivery, Obstetric
dc.subject.mesh	Humans
dc.subject.mesh	Infant
dc.subject.mesh	Ireland
dc.subject.mesh	Longitudinal Studies
dc.subject.mesh	Male
dc.subject.mesh	Pediatric Obesity
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Risk Factors
dc.title	Association between caesarean section delivery and obesity in childhood: a longitudinal cohort study in Ireland.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	England
utslib.for	1103 Clinical Sciences
utslib.for	1117 Public Health and Health Services
utslib.for	1199 Other Medical and Health Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Women & Children’s Health Research Collaborative (WCHC)
pubs.organisational-group	University of Technology Sydney/UTS Groups/INSIGHT: Institute for Innovative Solutions for Well-being and Health
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated	2025-01-13T02:58:14Z
pubs.issue	3
pubs.publication-status	Published online
pubs.volume	9
utslib.citation.issue	3

Abstract:

OBJECTIVES: To investigate the association between caesarean section (CS) birth and body fat percentage (BF%), body mass index (BMI) and being overweight or obese in early childhood. DESIGN: Prospective longitudinal cohort study. SETTING: Babies After Screening for Pregnancy Endpoints: Evaluating the Longitudinal Impact on Neurological and Nutritional Endpoints cohort. PARTICIPANTS: Infants born to mothers recruited from the Screening for Pregnancy Endpoints study, Cork University Maternity Hospital between November 2007 and February 2011. OUTCOME MEASURE: Overweight or obese defined according to the International Obesity Task Force criteria. RESULTS: Of the 1305 infants, 362 (27.8%) were delivered by CS. On regression analysis, BF% at 2 months did not differ significantly by delivery mode. Infants born by CS had a higher mean BMI at 6 months compared with those born vaginally (adjusted mean difference=0.24; 95% CI 0.06 to 0.41, p value=0.009). At 2 years, no difference was seen across the exposure groups in the risk of being overweight or obese. At 5 years, the association between prelabour CS and the risk of overweight or obesity was not statistically significant (adjusted relative risk ratio, aRRR=1.37; 95% CI 0.69 to 2.69) and the association remained statistically nonsignificant when children who were macrosomic at birth were excluded from the model (aRRR=0.86; 95% CI 0.36 to 2.08). CONCLUSION: At 6 months of age, children born by CS had a significantly higher BMI but this did not persist into future childhood. There was no evidence to support an association between mode of delivery and long-term risk of obesity in the child.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/183326