Global summary of maternal and newborn vitamin D status - a systematic review.

Saraf, R; Morton, SMB; Camargo, CA; Grant, CC

Global summary of maternal and newborn vitamin D status - a systematic review.

Saraf, R Morton, SMB Camargo, CA Grant, CC

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Matern Child Nutr, 2016, 12, (4), pp. 647-668
Issue Date:: 2016-10

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Field	Value	Language
dc.contributor.author	Saraf, R
dc.contributor.author	Morton, SMB
dc.contributor.author	Camargo, CA
dc.contributor.author	Grant, CC
dc.date.accessioned	2025-01-13T03:03:23Z
dc.date.available	2025-01-13T03:03:23Z
dc.date.issued	2016-10
dc.identifier.citation	Matern Child Nutr, 2016, 12, (4), pp. 647-668
dc.identifier.issn	1740-8695
dc.identifier.issn	1740-8709
dc.identifier.uri	http://hdl.handle.net/10453/183338
dc.description.abstract	Pregnant women and newborns are at increased risk of vitamin D deficiency. Our objective was to create a global summary of maternal and newborn vitamin D status. We completed a systematic review (1959-2014) and meta-analysis of studies reporting serum 25-hydroxyvitamin D [25(OH)D] concentration in maternal and newborn populations. The 95 identified studies were unevenly distributed by World Health Organization (WHO) region: Americas (24), European (33), Eastern Mediterranean (13), South-East Asian (7), Western Pacific (16) and African (2). Average maternal 25(OH)D concentrations (nmol L(-1) ) by region were 47-65 (Americas), 15-72 (European), 13-60 (Eastern Mediterranean), 20-52 (South-East Asian), 42-72 (Western Pacific) and 92 (African). Average newborn 25(OH)D concentrations (nmol L(-1) ) were 35-77 (Americas), 20-50 (European), 5-50 (Eastern Mediterranean), 20-22 (South-East Asian), 32-67 (Western Pacific) and 27-35 (African). The prevalences of 25(OH)D <50 and <25 nmol L(-1) by WHO region in pregnant women were: Americas (64%, 9%), European (57%, 23%), Eastern Mediterranean (46%, 79%), South-East Asian (87%, not available) and Western Pacific (83%, 13%). Among newborns these values were: Americas (30%, 14%), European (73%, 39%), Eastern Mediterranean (60%, not available), South-East Asian (96%, 45%) and Western Pacific (54%, 14%). By global region, average 25(OH)D concentration varies threefold in pregnant women and newborns, and prevalence of 25(OH)D <25 nmol L(-1) varies eightfold in pregnant women and threefold in newborns. Maternal and newborn 25(OH)D concentrations are highly correlated. Addressing vitamin D deficiency in pregnant women and newborns should be a global priority. To protect children from the adverse effects of vitamin D deficiency requires appropriate interventions during both pregnancy and childhood.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation.ispartof	Matern Child Nutr
dc.relation.isbasedon	10.1111/mcn.12210
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1111 Nutrition and Dietetics
dc.subject.classification	Nutrition & Dietetics
dc.subject.classification	3210 Nutrition and dietetics
dc.subject.classification	4204 Midwifery
dc.subject.mesh	Africa
dc.subject.mesh	Asia, Southeastern
dc.subject.mesh	Dietary Supplements
dc.subject.mesh	Female
dc.subject.mesh	Fetal Blood
dc.subject.mesh	Global Health
dc.subject.mesh	Health Status
dc.subject.mesh	Humans
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Maternal Health
dc.subject.mesh	Maternal Nutritional Physiological Phenomena
dc.subject.mesh	Mediterranean Region
dc.subject.mesh	Meta-Analysis as Topic
dc.subject.mesh	Nutritional Status
dc.subject.mesh	Pregnancy
dc.subject.mesh	Prevalence
dc.subject.mesh	United States
dc.subject.mesh	Vitamin D
dc.subject.mesh	Vitamin D Deficiency
dc.subject.mesh	Fetal Blood
dc.subject.mesh	Humans
dc.subject.mesh	Vitamin D Deficiency
dc.subject.mesh	Vitamin D
dc.subject.mesh	Prevalence
dc.subject.mesh	Health Status
dc.subject.mesh	Nutritional Status
dc.subject.mesh	Pregnancy
dc.subject.mesh	Dietary Supplements
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Africa
dc.subject.mesh	United States
dc.subject.mesh	Asia, Southeastern
dc.subject.mesh	Mediterranean Region
dc.subject.mesh	Female
dc.subject.mesh	Meta-Analysis as Topic
dc.subject.mesh	Maternal Nutritional Physiological Phenomena
dc.subject.mesh	Global Health
dc.subject.mesh	Maternal Health
dc.subject.mesh	Africa
dc.subject.mesh	Asia, Southeastern
dc.subject.mesh	Dietary Supplements
dc.subject.mesh	Female
dc.subject.mesh	Fetal Blood
dc.subject.mesh	Global Health
dc.subject.mesh	Health Status
dc.subject.mesh	Humans
dc.subject.mesh	Infant, Newborn
dc.subject.mesh	Maternal Health
dc.subject.mesh	Maternal Nutritional Physiological Phenomena
dc.subject.mesh	Mediterranean Region
dc.subject.mesh	Meta-Analysis as Topic
dc.subject.mesh	Nutritional Status
dc.subject.mesh	Pregnancy
dc.subject.mesh	Prevalence
dc.subject.mesh	United States
dc.subject.mesh	Vitamin D
dc.subject.mesh	Vitamin D Deficiency
dc.title	Global summary of maternal and newborn vitamin D status - a systematic review.
dc.type	Journal Article
utslib.citation.volume	12
utslib.location.activity	England
utslib.for	1111 Nutrition and Dietetics
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Women & Children’s Health Research Collaborative (WCHC)
pubs.organisational-group	University of Technology Sydney/UTS Groups/INSIGHT: Institute for Innovative Solutions for Well-being and Health
utslib.copyright.status	closed_access	*
dc.date.updated	2025-01-13T03:03:21Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	12
utslib.citation.issue	4

Abstract:

Pregnant women and newborns are at increased risk of vitamin D deficiency. Our objective was to create a global summary of maternal and newborn vitamin D status. We completed a systematic review (1959-2014) and meta-analysis of studies reporting serum 25-hydroxyvitamin D [25(OH)D] concentration in maternal and newborn populations. The 95 identified studies were unevenly distributed by World Health Organization (WHO) region: Americas (24), European (33), Eastern Mediterranean (13), South-East Asian (7), Western Pacific (16) and African (2). Average maternal 25(OH)D concentrations (nmol L(-1) ) by region were 47-65 (Americas), 15-72 (European), 13-60 (Eastern Mediterranean), 20-52 (South-East Asian), 42-72 (Western Pacific) and 92 (African). Average newborn 25(OH)D concentrations (nmol L(-1) ) were 35-77 (Americas), 20-50 (European), 5-50 (Eastern Mediterranean), 20-22 (South-East Asian), 32-67 (Western Pacific) and 27-35 (African). The prevalences of 25(OH)D <50 and <25 nmol L(-1) by WHO region in pregnant women were: Americas (64%, 9%), European (57%, 23%), Eastern Mediterranean (46%, 79%), South-East Asian (87%, not available) and Western Pacific (83%, 13%). Among newborns these values were: Americas (30%, 14%), European (73%, 39%), Eastern Mediterranean (60%, not available), South-East Asian (96%, 45%) and Western Pacific (54%, 14%). By global region, average 25(OH)D concentration varies threefold in pregnant women and newborns, and prevalence of 25(OH)D <25 nmol L(-1) varies eightfold in pregnant women and threefold in newborns. Maternal and newborn 25(OH)D concentrations are highly correlated. Addressing vitamin D deficiency in pregnant women and newborns should be a global priority. To protect children from the adverse effects of vitamin D deficiency requires appropriate interventions during both pregnancy and childhood.

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http://hdl.handle.net/10453/183338