Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy

Shan, X; Ding, L; Wang, D; Wen, S; Shi, J; Chen, C; Wang, Y; Zhu, H; Huang, Z; Wang, SSJ; Zhong, X; Liu, B; Reece, PJ; Ren, W; Hao, W; Lu, X; Lu, J; Su, QP; Chang, L; Sun, L; Jin, D; Jiang, L; Wang, F

Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy

Shan, X Ding, L

Wang, D Wen, S

Shi, J Chen, C

Wang, Y Zhu, H Huang, Z Wang, SSJ Zhong, X Liu, B Reece, PJ Ren, W Hao, W Lu, X Lu, J

Su, QP Chang, L Sun, L Jin, D

Jiang, L Wang, F

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Publisher:: NATURE PORTFOLIO
Publication Type:: Journal Article
Citation:: Nature Photonics, 2024, 18, (9), pp. 913-921
Issue Date:: 2024-09-01

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Field	Value	Language
dc.contributor.author	Shan, X
dc.contributor.author	Ding, L https://orcid.org/0000-0002-9574-5165
dc.contributor.author	Wang, D
dc.contributor.author	Wen, S https://orcid.org/0000-0002-4670-4658
dc.contributor.author	Shi, J
dc.contributor.author	Chen, C https://orcid.org/0000-0002-5613-2622
dc.contributor.author	Wang, Y
dc.contributor.author	Zhu, H
dc.contributor.author	Huang, Z
dc.contributor.author	Wang, SSJ
dc.contributor.author	Zhong, X
dc.contributor.author	Liu, B
dc.contributor.author	Reece, PJ
dc.contributor.author	Ren, W
dc.contributor.author	Hao, W
dc.contributor.author	Lu, X
dc.contributor.author	Lu, J https://orcid.org/0000-0003-0690-4732
dc.contributor.author	Su, QP
dc.contributor.author	Chang, L
dc.contributor.author	Sun, L
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666
dc.contributor.author	Jiang, L
dc.contributor.author	Wang, F
dc.date.accessioned	2025-01-22T05:43:39Z
dc.date.available	2025-01-22T05:43:39Z
dc.date.issued	2024-09-01
dc.identifier.citation	Nature Photonics, 2024, 18, (9), pp. 913-921
dc.identifier.issn	1749-4885
dc.identifier.issn	1749-4893
dc.identifier.uri	http://hdl.handle.net/10453/184008
dc.description.abstract	Correction Notice Issued: A correction to this article has been published: In the version of the article initially published, the National Natural Science Foundation of China grant no. U23A20481 was missing from the Acknowledgements and has now been added to the HTML and PDF versions of the article. See: https://doi.org/10.1038/s41566-024-01518-8.
dc.description.abstract	Precise force measurement is critical to probe biological events and physics processes, spanning from molecular motor’s motion to the Casimir effect, as well as the detection of gravitational waves. Yet, despite extensive technological developments, the three-dimensional nanoscale measurement of weak forces in aqueous solutions still faces major challenges. Techniques that rely on optically trapped nanoprobes are of significant potential but are beset with limitations, including probe heating induced by high trapping power, undetectable scattering signals and localization errors. Here we report the measurement of the long-distance interaction force in aqueous solutions with a minimum detected force value of 108.2 ± 510.0 attonewton. To achieve this, we develop a super-resolved photonic force microscope based on optically trapped lanthanide-doped nanoparticles coupled with nanoscale three-dimensional tracking-based force sensing. The tracking method leverages neural-network-empowered super-resolution localization, where the position of the force probe is extracted from the optical-astigmatism-modified point spread function. We achieve a force sensitivity down to 1.8 fN Hz–1/2, which approaches the nanoscale thermal limit. We experimentally measure electrophoresis forces acting on single nanoparticles as well as the surface-induced interaction force on a single nanoparticle. This work opens the avenue of nanoscale thermally limited force sensing and offers new opportunities for detecting sub-femtonewton forces over long distances and biomechanical forces at the single-molecule level.
dc.language	English
dc.publisher	NATURE PORTFOLIO
dc.relation	Corrected by: http://hdl.handle.net/10453/184009
dc.relation	Correction notice available at publisher's site: https://doi.org/10.1038/s41566-024-01518-8
dc.relation.ispartof	Nature Photonics
dc.relation.isbasedon	10.1038/s41566-024-01462-7
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	01 Mathematical Sciences, 02 Physical Sciences
dc.subject.classification	Optoelectronics & Photonics
dc.subject.classification	49 Mathematical sciences
dc.subject.classification	51 Physical sciences
dc.title	Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy
dc.type	Journal Article
utslib.citation.volume	18
utslib.for	01 Mathematical Sciences
utslib.for	02 Physical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Electrical and Data Engineering
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Australian Artificial Intelligence Institute (AAII)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Institute of Biomedical Materials and Devices (IBMD)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Institute of Biomedical Materials and Devices (IBMD)/Institute of Biomedical Materials and Devices (IBMD) Associate Members
utslib.copyright.status	closed_access	*
dc.date.updated	2025-01-22T05:43:37Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	18
utslib.citation.issue	9

Abstract:

Correction Notice Issued: A correction to this article has been published: In the version of the article initially published, the National Natural Science Foundation of China grant no. U23A20481 was missing from the Acknowledgements and has now been added to the HTML and PDF versions of the article. See: https://doi.org/10.1038/s41566-024-01518-8. Precise force measurement is critical to probe biological events and physics processes, spanning from molecular motor’s motion to the Casimir effect, as well as the detection of gravitational waves. Yet, despite extensive technological developments, the three-dimensional nanoscale measurement of weak forces in aqueous solutions still faces major challenges. Techniques that rely on optically trapped nanoprobes are of significant potential but are beset with limitations, including probe heating induced by high trapping power, undetectable scattering signals and localization errors. Here we report the measurement of the long-distance interaction force in aqueous solutions with a minimum detected force value of 108.2 ± 510.0 attonewton. To achieve this, we develop a super-resolved photonic force microscope based on optically trapped lanthanide-doped nanoparticles coupled with nanoscale three-dimensional tracking-based force sensing. The tracking method leverages neural-network-empowered super-resolution localization, where the position of the force probe is extracted from the optical-astigmatism-modified point spread function. We achieve a force sensitivity down to 1.8 fN Hz–1/2, which approaches the nanoscale thermal limit. We experimentally measure electrophoresis forces acting on single nanoparticles as well as the surface-induced interaction force on a single nanoparticle. This work opens the avenue of nanoscale thermally limited force sensing and offers new opportunities for detecting sub-femtonewton forces over long distances and biomechanical forces at the single-molecule level.

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