Ion Current Rectification Activity Induced by Boron Hydride Nanosheets to Enhance Magnesium Analgesia

Liu, Y; Qi, Q; Jiang, Y; Zhao, P; Chen, L; Ma, X; Shi, Y; Xu, J; Li, J; Chen, F; Chen, J; Zhang, L; Wu, Y; Jiang, X; Jin, D; Xu, T; Bu, W

Ion Current Rectification Activity Induced by Boron Hydride Nanosheets to Enhance Magnesium Analgesia

Liu, Y Qi, Q Jiang, Y Zhao, P Chen, L Ma, X Shi, Y Xu, J Li, J Chen, F Chen, J Zhang, L

Wu, Y Jiang, X Jin, D

Xu, T Bu, W

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Angewandte Chemie, 2024, 136, (34)
Issue Date:: 2024-08-19

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Field	Value	Language
dc.contributor.author	Liu, Y
dc.contributor.author	Qi, Q
dc.contributor.author	Jiang, Y
dc.contributor.author	Zhao, P
dc.contributor.author	Chen, L
dc.contributor.author	Ma, X
dc.contributor.author	Shi, Y
dc.contributor.author	Xu, J
dc.contributor.author	Li, J
dc.contributor.author	Chen, F
dc.contributor.author	Chen, J
dc.contributor.author	Zhang, L https://orcid.org/0000-0003-0641-2383
dc.contributor.author	Wu, Y
dc.contributor.author	Jiang, X
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666
dc.contributor.author	Xu, T
dc.contributor.author	Bu, W
dc.date.accessioned	2025-01-22T06:02:21Z
dc.date.available	2025-01-22T06:02:21Z
dc.date.issued	2024-08-19
dc.identifier.citation	Angewandte Chemie, 2024, 136, (34)
dc.identifier.issn	0044-8249
dc.identifier.issn	1521-3757
dc.identifier.uri	http://hdl.handle.net/10453/184016
dc.description.abstract	<jats:title>Abstract</jats:title><jats:p>The limited analgesic efficiency of magnesium restricts its application in pain management. Here, we report boron hydride (BH) with ion currents rectification activity that can enhance the analgesic efficiency of magnesium without the risks of drug tolerance or addiction. We synthesize MgB<jats:sub>2</jats:sub>, comprising hexagonal boron sheets alternating with Mg<jats:sup>2+</jats:sup>. In pathological environment, Mg<jats:sup>2+</jats:sup> is exchanged by H<jats:sup>+</jats:sup>, forming two‐dimensional borophene‐analogue BH sheets. BH interacts with the charged cations via cation‐pi interaction, leading to dynamic modulation of sodium and potassium ion currents around neurons. Additionally, released Mg<jats:sup>2+</jats:sup> competes Ca<jats:sup>2+</jats:sup> to inhibit its influx and neuronal excitation. In vitro cultured dorsal root neurons show a remarkable increase in threshold potential from the normal −35.9 mV to −5.9 mV after the addition of MgB<jats:sub>2</jats:sub>, indicating potent analgesic effect. In three typical pain models, including CFA‐induced inflammatory pain, CINP‐ or CCI‐induced neuropathic pain, MgB<jats:sub>2</jats:sub> exhibits analgesic efficiency approximately 2.23, 3.20, and 2.0 times higher than clinical MgSO<jats:sub>4</jats:sub>, respectively, and even about 1.04, 1.66, and 1.95 times higher than morphine, respectively. The development of magnesium based intermetallic compounds holds promise in addressing the non‐opioid medical need for pain relief.</jats:p>
dc.language	en
dc.publisher	Wiley
dc.relation.ispartof	Angewandte Chemie
dc.relation.isbasedon	10.1002/ange.202405131
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	03 Chemical Sciences
dc.subject.classification	Organic Chemistry
dc.subject.classification	34 Chemical sciences
dc.title	Ion Current Rectification Activity Induced by Boron Hydride Nanosheets to Enhance Magnesium Analgesia
dc.type	Journal Article
utslib.citation.volume	136
utslib.for	03 Chemical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Institute of Biomedical Materials and Devices (IBMD)
utslib.copyright.status	closed_access	*
dc.date.updated	2025-01-22T06:02:20Z
pubs.issue	34
pubs.publication-status	Published
pubs.volume	136
utslib.citation.issue	34

Abstract:

AbstractThe limited analgesic efficiency of magnesium restricts its application in pain management. Here, we report boron hydride (BH) with ion currents rectification activity that can enhance the analgesic efficiency of magnesium without the risks of drug tolerance or addiction. We synthesize MgB2, comprising hexagonal boron sheets alternating with Mg2+. In pathological environment, Mg2+ is exchanged by H+, forming two‐dimensional borophene‐analogue BH sheets. BH interacts with the charged cations via cation‐pi interaction, leading to dynamic modulation of sodium and potassium ion currents around neurons. Additionally, released Mg2+ competes Ca2+ to inhibit its influx and neuronal excitation. In vitro cultured dorsal root neurons show a remarkable increase in threshold potential from the normal −35.9 mV to −5.9 mV after the addition of MgB2, indicating potent analgesic effect. In three typical pain models, including CFA‐induced inflammatory pain, CINP‐ or CCI‐induced neuropathic pain, MgB2 exhibits analgesic efficiency approximately 2.23, 3.20, and 2.0 times higher than clinical MgSO4, respectively, and even about 1.04, 1.66, and 1.95 times higher than morphine, respectively. The development of magnesium based intermetallic compounds holds promise in addressing the non‐opioid medical need for pain relief.

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http://hdl.handle.net/10453/184016