A Comprehensive Review and Androgen Deprivation Therapy and Its Impact on Alzheimer's Disease Risk in Older Men with Prostate Cancer.

Singh, M; Agarwal, V; Pancham, P; Jindal, D; Agarwal, S; Rai, SN; Singh, SK; Gupta, V

A Comprehensive Review and Androgen Deprivation Therapy and Its Impact on Alzheimer's Disease Risk in Older Men with Prostate Cancer.

Singh, M Agarwal, V Pancham, P Jindal, D Agarwal, S Rai, SN Singh, SK Gupta, V

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Publisher:: Taylor & Francis
Publication Type:: Journal Article
Citation:: Degener Neurol Neuromuscul Dis, 2024, 14, pp. 33-46
Issue Date:: 2024

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Field	Value	Language
dc.contributor.author	Singh, M
dc.contributor.author	Agarwal, V
dc.contributor.author	Pancham, P
dc.contributor.author	Jindal, D
dc.contributor.author	Agarwal, S
dc.contributor.author	Rai, SN
dc.contributor.author	Singh, SK
dc.contributor.author	Gupta, V
dc.date.accessioned	2025-01-28T05:50:01Z
dc.date.available	2024-05-03
dc.date.available	2025-01-28T05:50:01Z
dc.date.issued	2024
dc.identifier.citation	Degener Neurol Neuromuscul Dis, 2024, 14, pp. 33-46
dc.identifier.issn	1179-9900
dc.identifier.issn	1179-9900
dc.identifier.uri	http://hdl.handle.net/10453/184389
dc.description.abstract	Prostate cancer (PCa) is one of the most prevalent malignancies affecting males worldwide. Despite reductions in mortality rates due to advances in early identification and treatment methods, PCa remains a major health concern. Recent research has shed light on a possible link between PCa and Alzheimer's disease (AD), which is a significant neurological ailment that affects older males all over the world. Androgen deprivation therapy (ADT), a cornerstone therapeutic method used in conjunction with radiation and palliative care in advanced metastatic PCa cases, is critical for disease management. Evidence reveals a relationship between ADT and cognitive impairment. Hormonal manipulation may cause long-term cognitive problems through processes such as amyloid beta (Aβ) aggregation and neurofibrillary tangles (NFTs). Fluctuations in basal androgen levels can upset the delicate balance of genes that are sensitive to androgen levels, contributing to cognitive impairment. This detailed review dives into the various aspects of PCa aetiology and its relationship with cognitive decline. It investigates the discovery of particular biomarkers, as well as microRNAs (miRNAs), which play important roles in pathogenic progression. The review attempts to identify potential biomarkers associated with ADT-induced cerebral changes, including Aβ oligomer buildup, NFT formation, and tauopathy, which can contribute to early-onset dementia and cognitive impairment. Besides it further aims to provide insights into innovative diagnostic and therapeutic avenues for alleviating PCa and ADT-related cognitive sequelae by unravelling these complicated pathways and molecular mechanisms.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Taylor & Francis
dc.relation.ispartof	Degener Neurol Neuromuscul Dis
dc.relation.isbasedon	10.2147/DNND.S445130
dc.rights	info:eu-repo/semantics/openAccess
dc.title	A Comprehensive Review and Androgen Deprivation Therapy and Its Impact on Alzheimer's Disease Risk in Older Men with Prostate Cancer.
dc.type	Journal Article
utslib.citation.volume	14
utslib.location.activity	New Zealand
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated	2025-01-28T05:49:59Z
pubs.publication-status	Published online
pubs.volume	14

Abstract:

Prostate cancer (PCa) is one of the most prevalent malignancies affecting males worldwide. Despite reductions in mortality rates due to advances in early identification and treatment methods, PCa remains a major health concern. Recent research has shed light on a possible link between PCa and Alzheimer's disease (AD), which is a significant neurological ailment that affects older males all over the world. Androgen deprivation therapy (ADT), a cornerstone therapeutic method used in conjunction with radiation and palliative care in advanced metastatic PCa cases, is critical for disease management. Evidence reveals a relationship between ADT and cognitive impairment. Hormonal manipulation may cause long-term cognitive problems through processes such as amyloid beta (Aβ) aggregation and neurofibrillary tangles (NFTs). Fluctuations in basal androgen levels can upset the delicate balance of genes that are sensitive to androgen levels, contributing to cognitive impairment. This detailed review dives into the various aspects of PCa aetiology and its relationship with cognitive decline. It investigates the discovery of particular biomarkers, as well as microRNAs (miRNAs), which play important roles in pathogenic progression. The review attempts to identify potential biomarkers associated with ADT-induced cerebral changes, including Aβ oligomer buildup, NFT formation, and tauopathy, which can contribute to early-onset dementia and cognitive impairment. Besides it further aims to provide insights into innovative diagnostic and therapeutic avenues for alleviating PCa and ADT-related cognitive sequelae by unravelling these complicated pathways and molecular mechanisms.

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http://hdl.handle.net/10453/184389