A Brain-Targeting NIR-II Ferroptosis System: Effective Visualization and Oncotherapy for Orthotopic Glioblastoma.

Zhang, J; Han, L; Wu, H; Zhong, Y; Shangguan, P; Liu, Y; He, M; Sun, H; Song, C; Wang, X; Liu, Y; Wang, J; Zheng, L; Shi, B; Tang, BZ

A Brain-Targeting NIR-II Ferroptosis System: Effective Visualization and Oncotherapy for Orthotopic Glioblastoma.

Zhang, J Han, L Wu, H Zhong, Y Shangguan, P Liu, Y He, M Sun, H Song, C Wang, X Liu, Y Wang, J Zheng, L Shi, B

Tang, BZ

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Adv Sci (Weinh), 2023, 10, (13), pp. e2206333
Issue Date:: 2023-05

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Field	Value	Language
dc.contributor.author	Zhang, J
dc.contributor.author	Han, L
dc.contributor.author	Wu, H
dc.contributor.author	Zhong, Y
dc.contributor.author	Shangguan, P
dc.contributor.author	Liu, Y
dc.contributor.author	He, M
dc.contributor.author	Sun, H
dc.contributor.author	Song, C
dc.contributor.author	Wang, X
dc.contributor.author	Liu, Y
dc.contributor.author	Wang, J
dc.contributor.author	Zheng, L
dc.contributor.author	Shi, B https://orcid.org/0000-0002-1043-3163
dc.contributor.author	Tang, BZ
dc.date.accessioned	2025-01-28T06:52:30Z
dc.date.available	2025-01-28T06:52:30Z
dc.date.issued	2023-05
dc.identifier.citation	Adv Sci (Weinh), 2023, 10, (13), pp. e2206333
dc.identifier.issn	2198-3844
dc.identifier.issn	2198-3844
dc.identifier.uri	http://hdl.handle.net/10453/184431
dc.description.abstract	Near-infrared-II (NIR-II) ferroptosis activators offer promising potentials in in vivo theranostics of deep tumors, such as glioma. However, most cases are nonvisual iron-based systems that are blind for in vivo precise theranostic study. Additionally, the iron species and their associated nonspecific activations might trigger undesired detrimental effects on normal cells. Considering gold (Au) is an essential cofactor for life and it can specifically bind to tumor cells, Au(I)-based NIR-II ferroptosis nanoparticles (TBTP-Au NPs) for brain-targeted orthotopic glioblastoma theranostics are innovatively constructed. It achieves the real-time visual monitoring of both the BBB penetration and the glioblastoma targeting processes. Moreover, it is first validated that the released TBTP-Au specifically activates the effective heme oxygenase-1-regulated ferroptosis of glioma cells to greatly extend the survival time of glioma-bearing mice. This new ferroptosis mechanism based on Au(I) may open a new way for the fabrication of advanced and high-specificity visual anticancer drugs for clinical trials.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation.ispartof	Adv Sci (Weinh)
dc.relation.isbasedon	10.1002/advs.202206333
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Glioblastoma
dc.subject.mesh	Ferroptosis
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Brain
dc.subject.mesh	Brain Neoplasms
dc.subject.mesh	Glioma
dc.subject.mesh	Iron
dc.subject.mesh	Brain
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Glioma
dc.subject.mesh	Glioblastoma
dc.subject.mesh	Brain Neoplasms
dc.subject.mesh	Iron
dc.subject.mesh	Ferroptosis
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Glioblastoma
dc.subject.mesh	Ferroptosis
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Brain
dc.subject.mesh	Brain Neoplasms
dc.subject.mesh	Glioma
dc.subject.mesh	Iron
dc.title	A Brain-Targeting NIR-II Ferroptosis System: Effective Visualization and Oncotherapy for Orthotopic Glioblastoma.
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	Germany
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2025-01-28T06:52:27Z
pubs.issue	13
pubs.publication-status	Published
pubs.volume	10
utslib.citation.issue	13

Abstract:

Near-infrared-II (NIR-II) ferroptosis activators offer promising potentials in in vivo theranostics of deep tumors, such as glioma. However, most cases are nonvisual iron-based systems that are blind for in vivo precise theranostic study. Additionally, the iron species and their associated nonspecific activations might trigger undesired detrimental effects on normal cells. Considering gold (Au) is an essential cofactor for life and it can specifically bind to tumor cells, Au(I)-based NIR-II ferroptosis nanoparticles (TBTP-Au NPs) for brain-targeted orthotopic glioblastoma theranostics are innovatively constructed. It achieves the real-time visual monitoring of both the BBB penetration and the glioblastoma targeting processes. Moreover, it is first validated that the released TBTP-Au specifically activates the effective heme oxygenase-1-regulated ferroptosis of glioma cells to greatly extend the survival time of glioma-bearing mice. This new ferroptosis mechanism based on Au(I) may open a new way for the fabrication of advanced and high-specificity visual anticancer drugs for clinical trials.

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http://hdl.handle.net/10453/184431