Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy.

Sun, Y; Yang, Q; Xia, X; Li, X; Ruan, W; Zheng, M; Zou, Y; Shi, B

Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy.

Sun, Y Yang, Q Xia, X Li, X Ruan, W Zheng, M Zou, Y Shi, B

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Publisher:: FRONTIERS MEDIA SA
Publication Type:: Journal Article
Citation:: Front Bioeng Biotechnol, 2021, 9, pp. 755727
Issue Date:: 2021

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Field	Value	Language
dc.contributor.author	Sun, Y
dc.contributor.author	Yang, Q
dc.contributor.author	Xia, X
dc.contributor.author	Li, X
dc.contributor.author	Ruan, W
dc.contributor.author	Zheng, M
dc.contributor.author	Zou, Y
dc.contributor.author	Shi, B https://orcid.org/0000-0002-1043-3163
dc.date.accessioned	2025-01-28T06:55:24Z
dc.date.available	2021-09-24
dc.date.available	2025-01-28T06:55:24Z
dc.date.issued	2021
dc.identifier.citation	Front Bioeng Biotechnol, 2021, 9, pp. 755727
dc.identifier.issn	2296-4185
dc.identifier.issn	2296-4185
dc.identifier.uri	http://hdl.handle.net/10453/184436
dc.description.abstract	Despite all sorts of innovations in medical researches over the past decades, cancer remains a major threat to human health. Mitochondria are essential organelles in eukaryotic cells, and their dysfunctions contribute to numerous diseases including cancers. Mitochondria-targeted cancer therapy, which specifically delivers drugs into the mitochondria, is a promising strategy for enhancing anticancer treatment efficiency. However, owing to their special double-layered membrane system and highly negative potentials, mitochondria remain a challenging target for therapeutic agents to reach and access. Polymeric nanoparticles exceed in cancer therapy ascribed to their unique features including ideal biocompatibility, readily design and synthesis, as well as flexible ligand decoration. Significant efforts have been put forward to develop mitochondria-targeted polymeric nanoparticles. In this review, we focused on the smart design of polymeric nanosystems for mitochondria targeting and summarized the current applications in improving cancer therapy.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	FRONTIERS MEDIA SA
dc.relation.ispartof	Front Bioeng Biotechnol
dc.relation.isbasedon	10.3389/fbioe.2021.755727
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0699 Other Biological Sciences, 0903 Biomedical Engineering, 1004 Medical Biotechnology
dc.subject.classification	3106 Industrial biotechnology
dc.subject.classification	3206 Medical biotechnology
dc.subject.classification	4003 Biomedical engineering
dc.title	Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	Switzerland
utslib.for	0699 Other Biological Sciences
utslib.for	0903 Biomedical Engineering
utslib.for	1004 Medical Biotechnology
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2025-01-28T06:55:22Z
pubs.publication-status	Published online
pubs.volume	9

Abstract:

Despite all sorts of innovations in medical researches over the past decades, cancer remains a major threat to human health. Mitochondria are essential organelles in eukaryotic cells, and their dysfunctions contribute to numerous diseases including cancers. Mitochondria-targeted cancer therapy, which specifically delivers drugs into the mitochondria, is a promising strategy for enhancing anticancer treatment efficiency. However, owing to their special double-layered membrane system and highly negative potentials, mitochondria remain a challenging target for therapeutic agents to reach and access. Polymeric nanoparticles exceed in cancer therapy ascribed to their unique features including ideal biocompatibility, readily design and synthesis, as well as flexible ligand decoration. Significant efforts have been put forward to develop mitochondria-targeted polymeric nanoparticles. In this review, we focused on the smart design of polymeric nanosystems for mitochondria targeting and summarized the current applications in improving cancer therapy.

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http://hdl.handle.net/10453/184436