The contribution of cumulative blood pressure load to dementia, cognitive function and mortality in older adults.
- Publisher:
- LIPPINCOTT WILLIAMS & WILKINS
- Publication Type:
- Journal Article
- Citation:
- J Hypertens, 2024, 42, (11), pp. 1922-1931
- Issue Date:
- 2024-11-01
Open Access
Copyright Clearance Process
- Recently Added
- In Progress
- Open Access
This item is open access.
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author |
Xu, X |
|
dc.contributor.author | Catts, VS | |
dc.contributor.author | Harris, K | |
dc.contributor.author | Wang, N | |
dc.contributor.author | Numbers, K | |
dc.contributor.author | Trollor, J | |
dc.contributor.author | Brodaty, H | |
dc.contributor.author | Sachdev, PS | |
dc.contributor.author | Schutte, AE | |
dc.date.accessioned | 2025-02-19T02:52:26Z | |
dc.date.available | 2024-06-17 | |
dc.date.available | 2025-02-19T02:52:26Z | |
dc.date.issued | 2024-11-01 | |
dc.identifier.citation | J Hypertens, 2024, 42, (11), pp. 1922-1931 | |
dc.identifier.issn | 0263-6352 | |
dc.identifier.issn | 1473-5598 | |
dc.identifier.uri | http://hdl.handle.net/10453/185197 | |
dc.description.abstract | BACKGROUND: Few studies evaluated the contribution of long-term elevated blood pressure (BP) towards dementia and deaths. We examined the association between cumulative BP (cBP) load and dementia, cognitive decline, all-cause and cardiovascular deaths in older Australians. We also explored whether seated versus standing BP were associated with these outcomes. METHODS: The Sydney Memory and Aging Study included 1037 community-dwelling individuals aged 70-90 years, recruited from Sydney, Australia. Baseline data was collected in 2005-2007 and the cohort was followed for seven waves until 2021. cSBP load was calculated as the area under the curve (AUC) for SBP ≥140 mmHg divided by the AUC for all SBP values. Cumulative diastolic BP (cDBP) and pulse pressure (cPP) load were calculated using thresholds of 90 mmHg and 60 mmHg. Cox and mixed linear models were used to assess associations. RESULTS: Of 527 participants with both seated and standing BP data (47.7% men, median age 77), 152 (28.8%) developed dementia over a mean follow-up of 10.5 years. Higher cPP load was associated with a higher risk of all-cause deaths, and cSBP load was associated with a higher risk of cardiovascular deaths in multivariate models ( P for trend < 0.05). Associations between cPP load, dementia and cognitive decline lost statistical significance after adjustment for age. Differences between sitting and standing BP load were not associated with the outcomes. CONCLUSION: Long-term cPP load was associated with a higher risk of all-cause deaths and cSBP load associated with a higher risk of cardiovascular deaths in older Australians. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | |
dc.relation.ispartof | J Hypertens | |
dc.relation.isbasedon | 10.1097/HJH.0000000000003808 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, 1116 Medical Physiology | |
dc.subject.classification | Cardiovascular System & Hematology | |
dc.subject.classification | 3201 Cardiovascular medicine and haematology | |
dc.subject.classification | 3202 Clinical sciences | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Male | |
dc.subject.mesh | Female | |
dc.subject.mesh | Aged, 80 and over | |
dc.subject.mesh | Dementia | |
dc.subject.mesh | Blood Pressure | |
dc.subject.mesh | Cognition | |
dc.subject.mesh | Hypertension | |
dc.subject.mesh | Australia | |
dc.subject.mesh | Cognitive Dysfunction | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Dementia | |
dc.subject.mesh | Hypertension | |
dc.subject.mesh | Cognition | |
dc.subject.mesh | Blood Pressure | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Aged, 80 and over | |
dc.subject.mesh | Australia | |
dc.subject.mesh | Female | |
dc.subject.mesh | Male | |
dc.subject.mesh | Cognitive Dysfunction | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Male | |
dc.subject.mesh | Female | |
dc.subject.mesh | Aged, 80 and over | |
dc.subject.mesh | Dementia | |
dc.subject.mesh | Blood Pressure | |
dc.subject.mesh | Cognition | |
dc.subject.mesh | Hypertension | |
dc.subject.mesh | Australia | |
dc.subject.mesh | Cognitive Dysfunction | |
dc.title | The contribution of cumulative blood pressure load to dementia, cognitive function and mortality in older adults. | |
dc.type | Journal Article | |
utslib.citation.volume | 42 | |
utslib.location.activity | Netherlands | |
utslib.for | 1102 Cardiorespiratory Medicine and Haematology | |
utslib.for | 1103 Clinical Sciences | |
utslib.for | 1116 Medical Physiology | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Health | |
pubs.organisational-group | University of Technology Sydney/Faculty of Health/School of Nursing and Midwifery | |
utslib.copyright.status | open_access | * |
dc.rights.license | This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2025-02-19T02:52:24Z | |
pubs.issue | 11 | |
pubs.publication-status | Published | |
pubs.volume | 42 | |
utslib.citation.issue | 11 |
Abstract:
BACKGROUND: Few studies evaluated the contribution of long-term elevated blood pressure (BP) towards dementia and deaths. We examined the association between cumulative BP (cBP) load and dementia, cognitive decline, all-cause and cardiovascular deaths in older Australians. We also explored whether seated versus standing BP were associated with these outcomes. METHODS: The Sydney Memory and Aging Study included 1037 community-dwelling individuals aged 70-90 years, recruited from Sydney, Australia. Baseline data was collected in 2005-2007 and the cohort was followed for seven waves until 2021. cSBP load was calculated as the area under the curve (AUC) for SBP ≥140 mmHg divided by the AUC for all SBP values. Cumulative diastolic BP (cDBP) and pulse pressure (cPP) load were calculated using thresholds of 90 mmHg and 60 mmHg. Cox and mixed linear models were used to assess associations. RESULTS: Of 527 participants with both seated and standing BP data (47.7% men, median age 77), 152 (28.8%) developed dementia over a mean follow-up of 10.5 years. Higher cPP load was associated with a higher risk of all-cause deaths, and cSBP load was associated with a higher risk of cardiovascular deaths in multivariate models ( P for trend < 0.05). Associations between cPP load, dementia and cognitive decline lost statistical significance after adjustment for age. Differences between sitting and standing BP load were not associated with the outcomes. CONCLUSION: Long-term cPP load was associated with a higher risk of all-cause deaths and cSBP load associated with a higher risk of cardiovascular deaths in older Australians.
Please use this identifier to cite or link to this item:
Download statistics for the last 12 months
Not enough data to produce graph