H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Musaie, K; Abbaszadeh, S; Marais, K; Nosrati‐Siahmazgi, V; Rezaei, S; Xiao, B; Dua, K; Santos, HA; Shahbazi, M

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Musaie, K Abbaszadeh, S Marais, K Nosrati‐Siahmazgi, V Rezaei, S Xiao, B Dua, K

Santos, HA Shahbazi, M

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Publication Type:: Journal Article
Citation:: Advanced Functional Materials

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Field	Value	Language
dc.contributor.author	Musaie, K
dc.contributor.author	Abbaszadeh, S
dc.contributor.author	Marais, K
dc.contributor.author	Nosrati‐Siahmazgi, V
dc.contributor.author	Rezaei, S
dc.contributor.author	Xiao, B
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Santos, HA
dc.contributor.author	Shahbazi, M
dc.date.accessioned	2025-02-26T06:41:01Z
dc.date.available	2025-02-26T06:41:01Z
dc.identifier.citation	Advanced Functional Materials
dc.identifier.issn	1616-301X
dc.identifier.issn	1616-3028
dc.identifier.uri	http://hdl.handle.net/10453/185328
dc.description.abstract	<jats:title>Abstract</jats:title><jats:p>Tumor cells exploit abnormal redox homeostasis and the pro‐tumorigenic effect of reactive oxygen species (ROS) to enhance their survival and progression. However, excessively high levels of ROS can exceed the oxidative stress threshold of tumor cells, inducing cell death. This can occur by selectively elevating the concentration of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> in tumor cells through both endogenous and exogenous mechanisms. The generated H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> serves as a precursor for toxic ROS, such as <jats:sup>•</jats:sup>OH and <jats:sup>1</jats:sup>O<jats:sub>2</jats:sub>, via chemodynamic and photodynamic therapy, respectively, leading to apoptosis, necrosis, and ferroptosis. Strategies to boost H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> levels include direct delivery of exogenous H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> and amplifying endogenous H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> generation by inhibiting antioxidant enzymes, leveraging glucose oxidase, employing photocatalytic therapy (PCT), and utilizing metal peroxides. Among them, metal peroxides have displayed remarkable performance due to their excellent potential to elevate H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> concentration within tumor cells while simultaneously normalizing the acidic and hypoxic conditions of the tumor microenvironment (TME). Moreover, these nanostructures enhance tumor sensitivity to complementary treatments, like chemotherapy. This review summarizes advanced perspectives in the design, synthesis, and comparative analysis of H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>‐generating nanoplatforms, emphasizing their capacity to treat various cancers.</jats:p>
dc.language	en
dc.publisher	Wiley
dc.relation.ispartof	Advanced Functional Materials
dc.relation.isbasedon	10.1002/adfm.202425866
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	02 Physical Sciences, 03 Chemical Sciences, 09 Engineering
dc.subject.classification	Materials
dc.subject.classification	34 Chemical sciences
dc.subject.classification	40 Engineering
dc.subject.classification	51 Physical sciences
dc.title	H2O2‐Generating Advanced Nanomaterials for Cancer Treatment
dc.type	Journal Article
utslib.for	02 Physical Sciences
utslib.for	03 Chemical Sciences
utslib.for	09 Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Inflammation (CFI)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Inflammation (CFI)/Centre for Inflammation (CFI) Associate Members
pubs.organisational-group	University of Technology Sydney/UTS Groups/Australian Research Consortium in Complementary and Integrative Medicine (ARCCIM)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Stroke Research Collaborative
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated	2025-02-26T06:40:50Z
pubs.publication-status	Published online

Abstract:

AbstractTumor cells exploit abnormal redox homeostasis and the pro‐tumorigenic effect of reactive oxygen species (ROS) to enhance their survival and progression. However, excessively high levels of ROS can exceed the oxidative stress threshold of tumor cells, inducing cell death. This can occur by selectively elevating the concentration of H2O2 in tumor cells through both endogenous and exogenous mechanisms. The generated H2O2 serves as a precursor for toxic ROS, such as •OH and 1O2, via chemodynamic and photodynamic therapy, respectively, leading to apoptosis, necrosis, and ferroptosis. Strategies to boost H2O2 levels include direct delivery of exogenous H2O2 and amplifying endogenous H2O2 generation by inhibiting antioxidant enzymes, leveraging glucose oxidase, employing photocatalytic therapy (PCT), and utilizing metal peroxides. Among them, metal peroxides have displayed remarkable performance due to their excellent potential to elevate H2O2 concentration within tumor cells while simultaneously normalizing the acidic and hypoxic conditions of the tumor microenvironment (TME). Moreover, these nanostructures enhance tumor sensitivity to complementary treatments, like chemotherapy. This review summarizes advanced perspectives in the design, synthesis, and comparative analysis of H2O2‐generating nanoplatforms, emphasizing their capacity to treat various cancers.

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http://hdl.handle.net/10453/185328