Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review

van den Nieuwenhof, DWA; Moroni, L; Chou, J; Hinkelbein, J

Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review

van den Nieuwenhof, DWA Moroni, L Chou, J Hinkelbein, J

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Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: npj Microgravity, 2024, 10, (1), pp. 102
Issue Date:: 2024-11-06

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Field	Value	Language
dc.contributor.author	van den Nieuwenhof, DWA
dc.contributor.author	Moroni, L
dc.contributor.author	Chou, J
dc.contributor.author	Hinkelbein, J
dc.date.accessioned	2025-02-27T03:17:44Z
dc.date.available	2024-10-24
dc.date.available	2025-02-27T03:17:44Z
dc.date.issued	2024-11-06
dc.identifier.citation	npj Microgravity, 2024, 10, (1), pp. 102
dc.identifier.issn	2373-8065
dc.identifier.issn	2373-8065
dc.identifier.uri	http://hdl.handle.net/10453/185374
dc.description.abstract	The rising aging population underscores the need for advances in tissue engineering and regenerative medicine. Alterations in cellular response in microgravity might be pivotal in unraveling the intricate cellular mechanisms governing tissue and organ regeneration. Microgravity could improve multicellular spheroid, tissue, and organ formation. This review summarizes microgravity-induced cellular alterations and highlights the potential of tissue engineering in microgravity for future breakthroughs in space travel, transplantation, drug testing, and personalized medicine.
dc.format	Electronic
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	npj Microgravity
dc.relation.isbasedon	10.1038/s41526-024-00442-z
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	United States
utslib.copyright.status	open_access	*
pubs.consider-herdc	true
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated	2025-02-27T03:17:41Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	10
utslib.citation.issue	1

Abstract:

The rising aging population underscores the need for advances in tissue engineering and regenerative medicine. Alterations in cellular response in microgravity might be pivotal in unraveling the intricate cellular mechanisms governing tissue and organ regeneration. Microgravity could improve multicellular spheroid, tissue, and organ formation. This review summarizes microgravity-induced cellular alterations and highlights the potential of tissue engineering in microgravity for future breakthroughs in space travel, transplantation, drug testing, and personalized medicine.

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http://hdl.handle.net/10453/185374