Pharmacological modulation of PI3K/PTEN/Akt/mTOR/ERK signaling pathways in ischemic injury: a mechanistic perspective.

Khan, H; Singh, A; Singh, Y; Sharma, D; Dua, K; Grewal, AK; Singh, TG

Pharmacological modulation of PI3K/PTEN/Akt/mTOR/ERK signaling pathways in ischemic injury: a mechanistic perspective.

Khan, H Singh, A Singh, Y Sharma, D Dua, K

Grewal, AK Singh, TG

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: Metab Brain Dis, 2025, 40, (3), pp. 131
Issue Date:: 2025-02-26

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Field	Value	Language
dc.contributor.author	Khan, H
dc.contributor.author	Singh, A
dc.contributor.author	Singh, Y
dc.contributor.author	Sharma, D
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Grewal, AK
dc.contributor.author	Singh, TG
dc.date.accessioned	2025-03-01T13:24:42Z
dc.date.available	2025-01-21
dc.date.available	2025-03-01T13:24:42Z
dc.date.issued	2025-02-26
dc.identifier.citation	Metab Brain Dis, 2025, 40, (3), pp. 131
dc.identifier.issn	0885-7490
dc.identifier.issn	1573-7365
dc.identifier.uri	http://hdl.handle.net/10453/185466
dc.description.abstract	Ischemia, also known as ischemia, relates to the reduced blood movement to a cells, muscle group, or organ in the body, culminating in an insufficient amount of oxygen required for cellular metabolism and the maintenance of tissue viability. There are different types of stroke (ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage), and different causes of stroke (e.g., cardioembolic, atherothrombotic, lacunar ischemic strokes, aneurysmal subarachnoid hemorrhage). It also includes other disorders affecting the blood vessels in the brain (e.g., vascular malformations, unruptured aneurysms). Each of these conditions has different characteristics in terms of how common they are and how they are managed. Stroke is the primary and catastrophic clinical presentation of all cerebrovascular diseases. In this review we focused about the importance of PI3K/AKT signaling pathways which are important in the onset of ischemia-reperfusion (I/R) injury. In addition, mTOR, a target that is activated by the PI3K/Akt signaling pathway, is both required and capable of providing enough protection to the heart against harm caused by I/R. Moreover, the signaling pathways that involve PI3K/Akt/Erk/PTEN/mTOR play a crucial role in facilitating the proliferation and maintenance of neurons following an ischemic stroke. The current review summarizes the molecular mechanisms of various signaling pathways in ischemic diseases and suggests targeting its receptors as a preventive approach based on pre-clinical and clinical studies.
dc.format	Electronic
dc.language	eng
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	Metab Brain Dis
dc.relation.isbasedon	10.1007/s11011-025-01543-8
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1109 Neurosciences
dc.subject.classification	Neurology & Neurosurgery
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	3209 Neurosciences
dc.subject.classification	5202 Biological psychology
dc.subject.mesh	Humans
dc.subject.mesh	TOR Serine-Threonine Kinases
dc.subject.mesh	Animals
dc.subject.mesh	Phosphatidylinositol 3-Kinases
dc.subject.mesh	Signal Transduction
dc.subject.mesh	Proto-Oncogene Proteins c-akt
dc.subject.mesh	Brain Ischemia
dc.subject.mesh	PTEN Phosphohydrolase
dc.subject.mesh	MAP Kinase Signaling System
dc.subject.mesh	Reperfusion Injury
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Brain Ischemia
dc.subject.mesh	Reperfusion Injury
dc.subject.mesh	Signal Transduction
dc.subject.mesh	MAP Kinase Signaling System
dc.subject.mesh	Proto-Oncogene Proteins c-akt
dc.subject.mesh	PTEN Phosphohydrolase
dc.subject.mesh	Phosphatidylinositol 3-Kinases
dc.subject.mesh	TOR Serine-Threonine Kinases
dc.title	Pharmacological modulation of PI3K/PTEN/Akt/mTOR/ERK signaling pathways in ischemic injury: a mechanistic perspective.
dc.type	Journal Article
utslib.citation.volume	40
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
utslib.for	1109 Neurosciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Inflammation (CFI)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Inflammation (CFI)/Centre for Inflammation (CFI) Associate Members
pubs.organisational-group	University of Technology Sydney/UTS Groups/Australian Research Consortium in Complementary and Integrative Medicine (ARCCIM)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Stroke Research Collaborative
utslib.copyright.status	closed_access	*
dc.date.updated	2025-03-01T13:24:36Z
pubs.issue	3
pubs.publication-status	Published online
pubs.volume	40
utslib.citation.issue	3

Abstract:

Ischemia, also known as ischemia, relates to the reduced blood movement to a cells, muscle group, or organ in the body, culminating in an insufficient amount of oxygen required for cellular metabolism and the maintenance of tissue viability. There are different types of stroke (ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage), and different causes of stroke (e.g., cardioembolic, atherothrombotic, lacunar ischemic strokes, aneurysmal subarachnoid hemorrhage). It also includes other disorders affecting the blood vessels in the brain (e.g., vascular malformations, unruptured aneurysms). Each of these conditions has different characteristics in terms of how common they are and how they are managed. Stroke is the primary and catastrophic clinical presentation of all cerebrovascular diseases. In this review we focused about the importance of PI3K/AKT signaling pathways which are important in the onset of ischemia-reperfusion (I/R) injury. In addition, mTOR, a target that is activated by the PI3K/Akt signaling pathway, is both required and capable of providing enough protection to the heart against harm caused by I/R. Moreover, the signaling pathways that involve PI3K/Akt/Erk/PTEN/mTOR play a crucial role in facilitating the proliferation and maintenance of neurons following an ischemic stroke. The current review summarizes the molecular mechanisms of various signaling pathways in ischemic diseases and suggests targeting its receptors as a preventive approach based on pre-clinical and clinical studies.

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http://hdl.handle.net/10453/185466