Cu(II) complexes using acylhydrazones or cyclen for biocidal antifouling coatings

Robinson, H; Daines, AM; Brackovic, A; Williams, DBG; Sims, IM; Hinkley, SFR

Cu(II) complexes using acylhydrazones or cyclen for biocidal antifouling coatings

Robinson, H Daines, AM Brackovic, A Williams, DBG Sims, IM Hinkley, SFR

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Publisher:: WALTER DE GRUYTER GMBH
Publication Type:: Journal Article
Citation:: Pure and Applied Chemistry, 2024, 96, (4), pp. 549-564
Issue Date:: 2024-04-01

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Field	Value	Language
dc.contributor.author	Robinson, H
dc.contributor.author	Daines, AM
dc.contributor.author	Brackovic, A
dc.contributor.author	Williams, DBG
dc.contributor.author	Sims, IM
dc.contributor.author	Hinkley, SFR
dc.date.accessioned	2025-03-06T00:48:59Z
dc.date.available	2025-03-06T00:48:59Z
dc.date.issued	2024-04-01
dc.identifier.citation	Pure and Applied Chemistry, 2024, 96, (4), pp. 549-564
dc.identifier.issn	0033-4545
dc.identifier.issn	1365-3075
dc.identifier.uri	http://hdl.handle.net/10453/185519
dc.description.abstract	Copper and copper-based compounds have broad spectrum antimicrobial activity, but concerns about leaching into the environment and toxicity on non-target organisms is leading the use of copper-based coatings being restricted. Our objective was to develop coatings that used the biocidal activity of copper, but with low negative impacts by reducing its leaching into the environment. This study reports the synthesis and characterisation of copper coordinating ligands, their formulation into coatings and testing of their antibacterial activity. A polyacylhydrazone and a series of simple acylhydrazones were synthesised and coordinated to Cu(II), but were considered unsuitable due to either their poor water-solubility or high levels of copper leaching. In an alternative approach, copper was successfully chelated to the tetraazamacrocycle, cyclen, and used to synthesise Cu(II)-cyclen functionalised silica particles, which were successfully combined with commercial paint formulations. These functionalised products showed poor antibacterial activity when incorporated into epoxy coatings, probably due to the low copper content of the formulations. However, these ligands may have other applications, such as removal of heavy metals from contaminated effluent steams.
dc.language	English
dc.publisher	WALTER DE GRUYTER GMBH
dc.relation.ispartof	Pure and Applied Chemistry
dc.relation.isbasedon	10.1515/pac-2024-0203
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	03 Chemical Sciences
dc.subject.classification	General Chemistry
dc.subject.classification	34 Chemical sciences
dc.title	Cu(II) complexes using acylhydrazones or cyclen for biocidal antifouling coatings
dc.type	Journal Article
utslib.citation.volume	96
utslib.for	03 Chemical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Clean Energy Technology (CCET)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Clean Energy Technology (CCET)/Centre for Clean Energy Technology (CCET) Associate Members
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated	2025-03-06T00:48:57Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	96
utslib.citation.issue	4

Abstract:

Copper and copper-based compounds have broad spectrum antimicrobial activity, but concerns about leaching into the environment and toxicity on non-target organisms is leading the use of copper-based coatings being restricted. Our objective was to develop coatings that used the biocidal activity of copper, but with low negative impacts by reducing its leaching into the environment. This study reports the synthesis and characterisation of copper coordinating ligands, their formulation into coatings and testing of their antibacterial activity. A polyacylhydrazone and a series of simple acylhydrazones were synthesised and coordinated to Cu(II), but were considered unsuitable due to either their poor water-solubility or high levels of copper leaching. In an alternative approach, copper was successfully chelated to the tetraazamacrocycle, cyclen, and used to synthesise Cu(II)-cyclen functionalised silica particles, which were successfully combined with commercial paint formulations. These functionalised products showed poor antibacterial activity when incorporated into epoxy coatings, probably due to the low copper content of the formulations. However, these ligands may have other applications, such as removal of heavy metals from contaminated effluent steams.

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http://hdl.handle.net/10453/185519