A low fouling and high biocompatibility electrochemical sensor based on the electrospun gelatin-PLGA-CNTs nanofibers for dopamine detection in blood

Deng, Z; Bao, D; Jiang, L; Zhang, X; Xi, W; Zheng, W; Xu, X

A low fouling and high biocompatibility electrochemical sensor based on the electrospun gelatin-PLGA-CNTs nanofibers for dopamine detection in blood

Deng, Z Bao, D Jiang, L Zhang, X Xi, W Zheng, W Xu, X

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Journal of Applied Polymer Science, 2024, 141, (38)
Issue Date:: 2024-10-10

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Field	Value	Language
dc.contributor.author	Deng, Z
dc.contributor.author	Bao, D
dc.contributor.author	Jiang, L
dc.contributor.author	Zhang, X
dc.contributor.author	Xi, W
dc.contributor.author	Zheng, W
dc.contributor.author	Xu, X https://orcid.org/0000-0002-2598-3766
dc.date.accessioned	2025-03-19T02:47:39Z
dc.date.available	2025-03-19T02:47:39Z
dc.date.issued	2024-10-10
dc.identifier.citation	Journal of Applied Polymer Science, 2024, 141, (38)
dc.identifier.issn	0021-8995
dc.identifier.issn	1097-4628
dc.identifier.uri	http://hdl.handle.net/10453/185985
dc.description.abstract	The ability to fabricate resisting nonspecific protein adsorption electrochemical sensor capable of high biocompatibility in vivo will undoubtedly underpin key future developments in life sciences. Herein, a gelatin-poly(lactide-co-glycolide)-carbon nanotubes nanofibers-membrane in three-dimensional porous structure without any chemical crosslinking is constructed on the carbon fiber microelectrode (e-Gelatin-PLGA-CNTs/CFME) using a one-step electrospinning technology. The nanofibers-membrane still presents good three-dimensional porous structure and excellent hydrophily after implantation in BSA solution. In addition, the dopamine hydrochloride (DA) sensitivity at e-Gelatin-PLGA-CNTs/CFME after implantation in human blood samples exhibits almost the same as preimplantation (91% ± 9%, n = 3). Importantly, the nanofibers-membrane possesses fast cell proliferation and a low hemolysis rate (2.27% ± 0.76%), satisfying the required biocompatibility as a constructed material for the detection in vivo. The constructed micro-electrochemical sensor realizes the detection of DA in human blood samples. Consequently, this strategy offers a new and facile platform for the development of implanted electrochemical sensor.
dc.language	en
dc.publisher	Wiley
dc.relation.ispartof	Journal of Applied Polymer Science
dc.relation.isbasedon	10.1002/app.55969
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	03 Chemical Sciences, 09 Engineering
dc.subject.classification	Polymers
dc.subject.classification	34 Chemical sciences
dc.subject.classification	40 Engineering
dc.title	A low fouling and high biocompatibility electrochemical sensor based on the electrospun gelatin-PLGA-CNTs nanofibers for dopamine detection in blood
dc.type	Journal Article
utslib.citation.volume	141
utslib.for	03 Chemical Sciences
utslib.for	09 Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2025-03-19T02:47:37Z
pubs.issue	38
pubs.publication-status	Published
pubs.volume	141
utslib.citation.issue	38

Abstract:

The ability to fabricate resisting nonspecific protein adsorption electrochemical sensor capable of high biocompatibility in vivo will undoubtedly underpin key future developments in life sciences. Herein, a gelatin-poly(lactide-co-glycolide)-carbon nanotubes nanofibers-membrane in three-dimensional porous structure without any chemical crosslinking is constructed on the carbon fiber microelectrode (e-Gelatin-PLGA-CNTs/CFME) using a one-step electrospinning technology. The nanofibers-membrane still presents good three-dimensional porous structure and excellent hydrophily after implantation in BSA solution. In addition, the dopamine hydrochloride (DA) sensitivity at e-Gelatin-PLGA-CNTs/CFME after implantation in human blood samples exhibits almost the same as preimplantation (91% ± 9%, n = 3). Importantly, the nanofibers-membrane possesses fast cell proliferation and a low hemolysis rate (2.27% ± 0.76%), satisfying the required biocompatibility as a constructed material for the detection in vivo. The constructed micro-electrochemical sensor realizes the detection of DA in human blood samples. Consequently, this strategy offers a new and facile platform for the development of implanted electrochemical sensor.

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http://hdl.handle.net/10453/185985