ANTI INFLAMMATORY ACTIVITY OF ALCOHOLIC EXTRACT OF Elaeagnus conferta Roxb SEEDS

Gupta, M; Gulati, M; Kapoor, B; Kumar, B; Gupta, R; Singh, N

ANTI INFLAMMATORY ACTIVITY OF ALCOHOLIC EXTRACT OF Elaeagnus conferta Roxb SEEDS

Gupta, M Gulati, M Kapoor, B Kumar, B Gupta, R Singh, N

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Publisher:: Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma
Publication Type:: Journal Article
Citation:: Rasayan Journal of Chemistry, 2024, 17, (3), pp. 1004-1009
Issue Date:: 2024-07-01

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Field	Value	Language
dc.contributor.author	Gupta, M
dc.contributor.author	Gulati, M
dc.contributor.author	Kapoor, B
dc.contributor.author	Kumar, B
dc.contributor.author	Gupta, R
dc.contributor.author	Singh, N
dc.date.accessioned	2025-03-28T04:37:52Z
dc.date.available	2025-03-28T04:37:52Z
dc.date.issued	2024-07-01
dc.identifier.citation	Rasayan Journal of Chemistry, 2024, 17, (3), pp. 1004-1009
dc.identifier.issn	0976-0083
dc.identifier.issn	0976-0083
dc.identifier.uri	http://hdl.handle.net/10453/186272
dc.description.abstract	The aim of the present investigation was to evaluate the anti-inflammatory activity of the methanolic extract of Elaeagnus conferta Roxb. (MEC) in male Wistar rats. The efficacy of MEC at a dose of 400 and 800 mg/kg was evaluated in animals treated with 1 carrageenan solution against indomethacin (50 mg/kg). Paw thickness, paw volume, and body weight were measured before the start of the study i.e. at t 0 and thereafter at t 3, 6, and 24h. The level of inflammatory mediators (IL-6, TNF- ) were accessed at t 24h. MEC exhibited a statistically significant decrease in paw thickness (22.71 ) and paw volume (63.89 ) and an increase in body weight (100.7 ) in a dose-dependent manner (p 0.001). Pre-treatment with MEC is effective in reducing inflammation by suppressing levels of inflammatory cytokines such as TNF- and IL-6 and results were found to be extremely significant compared with carrageenan-controlled animals. Furthermore, results suggested that E. conferta Roxb. significantly decreased inflammation, which may be attributed primarily to the presence of quercetin and ascorbic acid. Therefore, it can be explored for the management of inflammation-mediated disorders.
dc.language	en
dc.publisher	Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma
dc.relation.ispartof	Rasayan Journal of Chemistry
dc.relation.isbasedon	10.31788/RJC.2024.1738812
dc.rights	info:eu-repo/semantics/openAccess
dc.title	ANTI INFLAMMATORY ACTIVITY OF ALCOHOLIC EXTRACT OF Elaeagnus conferta Roxb SEEDS
dc.type	Journal Article
utslib.citation.volume	17
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2025-03-28T04:37:51Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	17
utslib.citation.issue	3

Abstract:

The aim of the present investigation was to evaluate the anti-inflammatory activity of the methanolic extract of Elaeagnus conferta Roxb. (MEC) in male Wistar rats. The efficacy of MEC at a dose of 400 and 800 mg/kg was evaluated in animals treated with 1 carrageenan solution against indomethacin (50 mg/kg). Paw thickness, paw volume, and body weight were measured before the start of the study i.e. at t 0 and thereafter at t 3, 6, and 24h. The level of inflammatory mediators (IL-6, TNF- ) were accessed at t 24h. MEC exhibited a statistically significant decrease in paw thickness (22.71 ) and paw volume (63.89 ) and an increase in body weight (100.7 ) in a dose-dependent manner (p 0.001). Pre-treatment with MEC is effective in reducing inflammation by suppressing levels of inflammatory cytokines such as TNF- and IL-6 and results were found to be extremely significant compared with carrageenan-controlled animals. Furthermore, results suggested that E. conferta Roxb. significantly decreased inflammation, which may be attributed primarily to the presence of quercetin and ascorbic acid. Therefore, it can be explored for the management of inflammation-mediated disorders.

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http://hdl.handle.net/10453/186272