The link between Alzheimer’s disease and stroke: A detrimental synergism

Behl, T; Kaur, I; Sehgal, A; Khandige, PS; Imran, M; Gulati, M; Khalid Anwer, M; Elossaily, GM; Ali, N; Wal, P; Gasmi, A

The link between Alzheimer’s disease and stroke: A detrimental synergism

Behl, T Kaur, I Sehgal, A Khandige, PS Imran, M Gulati, M Khalid Anwer, M Elossaily, GM Ali, N Wal, P Gasmi, A

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Ageing Research Reviews, 2024, 99, pp. 102388
Issue Date:: 2024-08

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Field	Value	Language
dc.contributor.author	Behl, T
dc.contributor.author	Kaur, I
dc.contributor.author	Sehgal, A
dc.contributor.author	Khandige, PS
dc.contributor.author	Imran, M
dc.contributor.author	Gulati, M
dc.contributor.author	Khalid Anwer, M
dc.contributor.author	Elossaily, GM
dc.contributor.author	Ali, N
dc.contributor.author	Wal, P
dc.contributor.author	Gasmi, A
dc.date.accessioned	2025-03-30T07:03:10Z
dc.date.available	2024-05-06
dc.date.available	2025-03-30T07:03:10Z
dc.date.issued	2024-08
dc.identifier.citation	Ageing Research Reviews, 2024, 99, pp. 102388
dc.identifier.issn	1568-1637
dc.identifier.issn	1872-9649
dc.identifier.uri	http://hdl.handle.net/10453/186305
dc.description.abstract	Being age-related disorders, both Alzheimer s disease (AD) and stroke share multiple risk factors, such as hypertension, smoking, diabetes, and apolipoprotein E (APOE) 4 genotype, and coexist in patients. Accumulation of amyloid- plaques and neurofibrillary tangled impair cognitive potential, leading to AD. Blocked blood flow in the neuronal tissues, causes neurodegeneration and cell death in stroke. AD is commonly characterized by cerebral amyloid angiopathy, which significantly elevates the risk of hemorrhagic stroke. Patients with AD and stroke have been both reported to exhibit greater cognitive impairment, followed by multiple pathophysiological mechanisms shared between the two. The manuscript aims to elucidate the relationship between AD and stroke, as well as the common pathways and risk factors while understanding the preventive therapies that might limit the negative impacts of this correlation, with diagnostic modalities and current AD treatments. The authors provide a comprehensive review of the link and aid the healthcare professionals to identify suitable targets and risk factors, that may retard cognitive decline and neurodegeneration in patients. However, more intricate research is required in this regard and an interdisciplinary approach that would target both the vascular and neurodegenerative factors would improve the quality of life in AD patients.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Ageing Research Reviews
dc.relation.isbasedon	10.1016/j.arr.2024.102388
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	0601 Biochemistry and Cell Biology, 1103 Clinical Sciences, 1109 Neurosciences
dc.subject.classification	Gerontology
dc.subject.classification	3101 Biochemistry and cell biology
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	3209 Neurosciences
dc.subject.mesh	Humans
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Risk Factors
dc.subject.mesh	Stroke
dc.subject.mesh	Animals
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Risk Factors
dc.subject.mesh	Stroke
dc.subject.mesh	Humans
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Risk Factors
dc.subject.mesh	Stroke
dc.subject.mesh	Animals
dc.title	The link between Alzheimer’s disease and stroke: A detrimental synergism
dc.type	Journal Article
utslib.citation.volume	99
utslib.location.activity	England
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1103 Clinical Sciences
utslib.for	1109 Neurosciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	in_progress	*
pubs.consider-herdc	true
dc.date.updated	2025-03-30T07:03:07Z
pubs.publication-status	Published
pubs.volume	99

Abstract:

Being age-related disorders, both Alzheimer s disease (AD) and stroke share multiple risk factors, such as hypertension, smoking, diabetes, and apolipoprotein E (APOE) 4 genotype, and coexist in patients. Accumulation of amyloid- plaques and neurofibrillary tangled impair cognitive potential, leading to AD. Blocked blood flow in the neuronal tissues, causes neurodegeneration and cell death in stroke. AD is commonly characterized by cerebral amyloid angiopathy, which significantly elevates the risk of hemorrhagic stroke. Patients with AD and stroke have been both reported to exhibit greater cognitive impairment, followed by multiple pathophysiological mechanisms shared between the two. The manuscript aims to elucidate the relationship between AD and stroke, as well as the common pathways and risk factors while understanding the preventive therapies that might limit the negative impacts of this correlation, with diagnostic modalities and current AD treatments. The authors provide a comprehensive review of the link and aid the healthcare professionals to identify suitable targets and risk factors, that may retard cognitive decline and neurodegeneration in patients. However, more intricate research is required in this regard and an interdisciplinary approach that would target both the vascular and neurodegenerative factors would improve the quality of life in AD patients.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/186305