Comparison of oven drying and freeze drying methods for the production of fast melt films containing quetiapine fumarate

Phang, HC; Ng, ZQ; Mohamad, N; Chew, YL; Balaraman, A; Kee, PE; Mishima, K; Goh, BH; Ming, LC; Bin Liew, K

Comparison of oven drying and freeze drying methods for the production of fast melt films containing quetiapine fumarate

Phang, HC Ng, ZQ Mohamad, N Chew, YL Balaraman, A Kee, PE Mishima, K Goh, BH Ming, LC Bin Liew, K

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Publisher:: Taylor and Francis
Publication Type:: Journal Article
Citation:: Drug Development and Industrial Pharmacy, 2024, 50, (9), pp. 810-826
Issue Date:: 2024-09

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Field	Value	Language
dc.contributor.author	Phang, HC
dc.contributor.author	Ng, ZQ
dc.contributor.author	Mohamad, N
dc.contributor.author	Chew, YL
dc.contributor.author	Balaraman, A
dc.contributor.author	Kee, PE
dc.contributor.author	Mishima, K
dc.contributor.author	Goh, BH
dc.contributor.author	Ming, LC
dc.contributor.author	Bin Liew, K
dc.date.accessioned	2025-03-31T02:13:34Z
dc.date.available	2025-03-31T02:13:34Z
dc.date.issued	2024-09
dc.identifier.citation	Drug Development and Industrial Pharmacy, 2024, 50, (9), pp. 810-826
dc.identifier.issn	0363-9045
dc.identifier.issn	1520-5762
dc.identifier.uri	http://hdl.handle.net/10453/186336
dc.description.abstract	BACKGROUND Quetiapine fumarate (QTP) is commonly prescribed for schizophrenic patient, typically available in tablet or oral suspension form, presenting challenges such as administration difficulties, fear of choking and distaste for its bitter taste. Fast melt films (FMF) offer an alternative dosage form with a simple development process, ease of administration and rapid drug absorption and action onset. OBJECTIVE This study aims to prepare FMF with different formulations using solvent casting methods and to compare the effects of different drying methods, including oven drying and freeze drying, on the properties of the films. METHODS Various formulations were created by manipulating polymer types (starch, hydroxypropyl methylcellulose (HPMC) and guar gum) at different concentrations, along with fixed concentrations of QTP and other excipients. Characterization tests including surface morphology, weight, thickness, pH, tensile strength, elongation length, Young s modulus, folding endurance and disintegration time were conducted. The optimal FMF formulation was identified and further evaluated for moisture and drug content, dissolution behavior, accelerated stability, X-ray diffraction (XRD), and palatability. RESULTS FMF containing 10 mg guar gum/film developed using oven drying emerged as the optimum choice, exhibiting desirable film appearance, ultra-thin thickness (0.453 0.002 mm), appropriate pH for oral intake (pH 5.0), optimal moisture content of 11.810 , rapid disintegration (52.67 1.53 s), high flexibility (folding endurance 300 times) and lower Young s modulus (1.308 0.214). CONCLUSION Oven drying method has been proven to be favorable for developing FMF containing QTP, meeting all testing criteria and providing an alternative option for QTP prescription.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Taylor and Francis
dc.relation.ispartof	Drug Development and Industrial Pharmacy
dc.relation.isbasedon	10.1080/03639045.2024.2409168
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.subject.mesh	Quetiapine Fumarate
dc.subject.mesh	Freeze Drying
dc.subject.mesh	Galactans
dc.subject.mesh	Plant Gums
dc.subject.mesh	Excipients
dc.subject.mesh	Mannans
dc.subject.mesh	Hypromellose Derivatives
dc.subject.mesh	Chemistry, Pharmaceutical
dc.subject.mesh	Drug Compounding
dc.subject.mesh	Tensile Strength
dc.subject.mesh	Solubility
dc.subject.mesh	Antipsychotic Agents
dc.subject.mesh	Desiccation
dc.subject.mesh	X-Ray Diffraction
dc.subject.mesh	Polymers
dc.subject.mesh	Polymers
dc.subject.mesh	Galactans
dc.subject.mesh	Mannans
dc.subject.mesh	Antipsychotic Agents
dc.subject.mesh	Excipients
dc.subject.mesh	Freeze Drying
dc.subject.mesh	X-Ray Diffraction
dc.subject.mesh	Desiccation
dc.subject.mesh	Drug Compounding
dc.subject.mesh	Chemistry, Pharmaceutical
dc.subject.mesh	Solubility
dc.subject.mesh	Tensile Strength
dc.subject.mesh	Plant Gums
dc.subject.mesh	Hypromellose Derivatives
dc.subject.mesh	Quetiapine Fumarate
dc.subject.mesh	Quetiapine Fumarate
dc.subject.mesh	Freeze Drying
dc.subject.mesh	Galactans
dc.subject.mesh	Plant Gums
dc.subject.mesh	Excipients
dc.subject.mesh	Mannans
dc.subject.mesh	Hypromellose Derivatives
dc.subject.mesh	Chemistry, Pharmaceutical
dc.subject.mesh	Drug Compounding
dc.subject.mesh	Tensile Strength
dc.subject.mesh	Solubility
dc.subject.mesh	Antipsychotic Agents
dc.subject.mesh	Desiccation
dc.subject.mesh	X-Ray Diffraction
dc.subject.mesh	Polymers
dc.title	Comparison of oven drying and freeze drying methods for the production of fast melt films containing quetiapine fumarate
dc.type	Journal Article
utslib.citation.volume	50
utslib.location.activity	England
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/School of Public Health
utslib.copyright.status	recently_added	*
pubs.consider-herdc	true
dc.date.updated	2025-03-31T02:13:31Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	50
utslib.citation.issue	9

Abstract:

BACKGROUND Quetiapine fumarate (QTP) is commonly prescribed for schizophrenic patient, typically available in tablet or oral suspension form, presenting challenges such as administration difficulties, fear of choking and distaste for its bitter taste. Fast melt films (FMF) offer an alternative dosage form with a simple development process, ease of administration and rapid drug absorption and action onset. OBJECTIVE This study aims to prepare FMF with different formulations using solvent casting methods and to compare the effects of different drying methods, including oven drying and freeze drying, on the properties of the films. METHODS Various formulations were created by manipulating polymer types (starch, hydroxypropyl methylcellulose (HPMC) and guar gum) at different concentrations, along with fixed concentrations of QTP and other excipients. Characterization tests including surface morphology, weight, thickness, pH, tensile strength, elongation length, Young s modulus, folding endurance and disintegration time were conducted. The optimal FMF formulation was identified and further evaluated for moisture and drug content, dissolution behavior, accelerated stability, X-ray diffraction (XRD), and palatability. RESULTS FMF containing 10 mg guar gum/film developed using oven drying emerged as the optimum choice, exhibiting desirable film appearance, ultra-thin thickness (0.453 0.002 mm), appropriate pH for oral intake (pH 5.0), optimal moisture content of 11.810 , rapid disintegration (52.67 1.53 s), high flexibility (folding endurance 300 times) and lower Young s modulus (1.308 0.214). CONCLUSION Oven drying method has been proven to be favorable for developing FMF containing QTP, meeting all testing criteria and providing an alternative option for QTP prescription.

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http://hdl.handle.net/10453/186336