Cost-effective synthesis of magnesium hydroxide and magnesium oxide by arc discharge method: Comparative studies for their biological activities

Mogadem, A; Elwakil, BH; Aljohani, FS; Paudel, KR; El-Khatib, M

Cost-effective synthesis of magnesium hydroxide and magnesium oxide by arc discharge method: Comparative studies for their biological activities

Mogadem, A Elwakil, BH Aljohani, FS Paudel, KR El-Khatib, M

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Ceramics International, 2025
Issue Date:: 2025-01-01

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Field	Value	Language
dc.contributor.author	Mogadem, A
dc.contributor.author	Elwakil, BH
dc.contributor.author	Aljohani, FS
dc.contributor.author	Paudel, KR
dc.contributor.author	El-Khatib, M
dc.date.accessioned	2025-05-05T01:25:47Z
dc.date.available	2025-05-05T01:25:47Z
dc.date.issued	2025-01-01
dc.identifier.citation	Ceramics International, 2025
dc.identifier.issn	0272-8842
dc.identifier.uri	http://hdl.handle.net/10453/187180
dc.description.abstract	Magnesium hydroxide and magnesium oxide nanoparticles are synthesized by an arc discharge method that is still new among biomedical field researchers. Generating one-dimensional Mg(OH)2 sheets and MgO nanoparticles (NPs) with different ratios was deduced for the first time using an economic Arc discharge technique using different electrical currents. Characterization was needed to confirm the purity, morphology, and particle size, which were examined by EDX, HR-TEM, XRD and Zeta potential. The obtained result indicated that the applied electrical current affected the yield produced and the nanoparticle's shape. Results revealed that the same diameter size (∼25 nm) with or without polygonal structure sheets and zeta potential −25 mV were produced. Both polygonal Mg(OH)2 sheets and MgO NPs showed the same mean ratio of peak intensities. The present study aimed to compare both types of magnesium nanoparticle structures regarding their potential biological activities. Cytotoxic effect was tested in the C-166 endothelial cell line, which revealed that the IC50 of MgO-NPs reached 387.34 μg/mL while Mg(OH)2 had 163.99 IC50. Additionally, the MgO showed strong anti-inflammatory properties in RAW 264.7 macrophages, with IC50 reaching 5.1 μg/mL, underscoring their potential medicinal uses. Moreover, MgO exhibited remarkable antibacterial activity with MIC values ranging between 15.6 and 125.0 μg/mL. According to these results, MgO nanoparticles offer exceptional qualities and a wide range of potential biological uses.
dc.language	en
dc.publisher	Elsevier
dc.relation.ispartof	Ceramics International
dc.relation.isbasedon	10.1016/j.ceramint.2025.03.454
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	03 Chemical Sciences, 09 Engineering, 19 Studies in Creative Arts and Writing
dc.subject.classification	Materials
dc.subject.classification	34 Chemical sciences
dc.subject.classification	36 Creative arts and writing
dc.subject.classification	40 Engineering
dc.title	Cost-effective synthesis of magnesium hydroxide and magnesium oxide by arc discharge method: Comparative studies for their biological activities
dc.type	Journal Article
utslib.for	03 Chemical Sciences
utslib.for	09 Engineering
utslib.for	19 Studies in Creative Arts and Writing
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Inflammation (CFI)
utslib.copyright.status	closed_access	*
dc.date.updated	2025-05-05T01:25:44Z
pubs.publication-status	Published

Abstract:

Magnesium hydroxide and magnesium oxide nanoparticles are synthesized by an arc discharge method that is still new among biomedical field researchers. Generating one-dimensional Mg(OH)2 sheets and MgO nanoparticles (NPs) with different ratios was deduced for the first time using an economic Arc discharge technique using different electrical currents. Characterization was needed to confirm the purity, morphology, and particle size, which were examined by EDX, HR-TEM, XRD and Zeta potential. The obtained result indicated that the applied electrical current affected the yield produced and the nanoparticle's shape. Results revealed that the same diameter size (∼25 nm) with or without polygonal structure sheets and zeta potential −25 mV were produced. Both polygonal Mg(OH)2 sheets and MgO NPs showed the same mean ratio of peak intensities. The present study aimed to compare both types of magnesium nanoparticle structures regarding their potential biological activities. Cytotoxic effect was tested in the C-166 endothelial cell line, which revealed that the IC50 of MgO-NPs reached 387.34 μg/mL while Mg(OH)2 had 163.99 IC50. Additionally, the MgO showed strong anti-inflammatory properties in RAW 264.7 macrophages, with IC50 reaching 5.1 μg/mL, underscoring their potential medicinal uses. Moreover, MgO exhibited remarkable antibacterial activity with MIC values ranging between 15.6 and 125.0 μg/mL. According to these results, MgO nanoparticles offer exceptional qualities and a wide range of potential biological uses.

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http://hdl.handle.net/10453/187180