Investigating the role of the gut-lung axis in chronic respiratory diseases: chronic obstructive pulmonary disease (COPD) and severe steroid resistant asthma (SSRA)

Jha, Piyush

Investigating the role of the gut-lung axis in chronic respiratory diseases: chronic obstructive pulmonary disease (COPD) and severe steroid resistant asthma (SSRA)

Jha, Piyush

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Publication Type:: Thesis
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Jha, Piyush
dc.date.accessioned	2025-05-08T06:36:18Z
dc.date.available	2025-05-08T06:36:18Z
dc.date.issued	2023
dc.identifier.uri	http://hdl.handle.net/10453/187277
dc.description	University of Technology Sydney. Faculty of Engineering and Information Technology.	en_US.UTF-8
dc.description.abstract	Chronic respiratory diseases (CRDs) including chronic obstructive pulmonary diseases (COPD) and severe asthma are very common and both does not effectively responds to corticosteroids therapy. The compositional changes in gut microbial diversity or abundance has been well documented in CRDs. However, the precise effect of modulation of gut microbiota and its effect on CRDs are to be explored further to establish a strong link for therapeutic pathways. In this thesis, I investigated modulation of gut microbiota by faecal microbial transfer (FMT) through oral gavage in experimental COPD and SSRAAD mice models. This thesis concluded, FMT with COPD microbiome in 6 weeks smoke exposure predisposes to COPD (Chapter 3), and in 8 weeks smoke exposure aggravates COPD features (Chapter 4). In SSRAAD, gut microbiome plays a role in airway neutrophilic inflammation (Chapter 5). I believe these studies provides an important platform from which future studies can be developed, and will ultimately help us to understand the mechanism and also to develop novel preventive and therapeutic strategies in COPD and severe asthma.	en_US.UTF-8
dc.format	Thesis (PhD)
dc.language.iso	en_US	en_US.UTF-8
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/187277/1/thesis.pdf
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	© 2023 Piyush Jha
dc.rights	au.edu.uts.lib/cph
dc.title	Investigating the role of the gut-lung axis in chronic respiratory diseases: chronic obstructive pulmonary disease (COPD) and severe steroid resistant asthma (SSRA)	en_US.UTF-8
dc.type	Thesis
utslib.copyright.status	open_access	*

Abstract:

Chronic respiratory diseases (CRDs) including chronic obstructive pulmonary diseases (COPD) and severe asthma are very common and both does not effectively responds to corticosteroids therapy. The compositional changes in gut microbial diversity or abundance has been well documented in CRDs. However, the precise effect of modulation of gut microbiota and its effect on CRDs are to be explored further to establish a strong link for therapeutic pathways. In this thesis, I investigated modulation of gut microbiota by faecal microbial transfer (FMT) through oral gavage in experimental COPD and SSRAAD mice models. This thesis concluded, FMT with COPD microbiome in 6 weeks smoke exposure predisposes to COPD (Chapter 3), and in 8 weeks smoke exposure aggravates COPD features (Chapter 4). In SSRAAD, gut microbiome plays a role in airway neutrophilic inflammation (Chapter 5). I believe these studies provides an important platform from which future studies can be developed, and will ultimately help us to understand the mechanism and also to develop novel preventive and therapeutic strategies in COPD and severe asthma.

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http://hdl.handle.net/10453/187277