Lanthanide-doped nanoprobes for microRNA detection

Liu, Y; Huang, Y; Luo, Y; Luo, Y; Jiang, L; Gallego-Ortega, D; Cheng, YY; Gale, PA; Bao, G

Lanthanide-doped nanoprobes for microRNA detection

Liu, Y Huang, Y Luo, Y Luo, Y Jiang, L Gallego-Ortega, D Cheng, YY Gale, PA Bao, G

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Publisher:: ELSEVIER SCIENCE SA
Publication Type:: Journal Article
Citation:: Coordination Chemistry Reviews, 2025, 536
Issue Date:: 2025-08-01

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Field	Value	Language
dc.contributor.author	Liu, Y
dc.contributor.author	Huang, Y
dc.contributor.author	Luo, Y
dc.contributor.author	Luo, Y
dc.contributor.author	Jiang, L
dc.contributor.author	Gallego-Ortega, D
dc.contributor.author	Cheng, YY
dc.contributor.author	Gale, PA
dc.contributor.author	Bao, G https://orcid.org/0000-0001-5103-5009
dc.date.accessioned	2025-09-22T03:57:23Z
dc.date.available	2025-09-22T03:57:23Z
dc.date.issued	2025-08-01
dc.identifier.citation	Coordination Chemistry Reviews, 2025, 536
dc.identifier.issn	0010-8545
dc.identifier.issn	1873-3840
dc.identifier.uri	http://hdl.handle.net/10453/190010
dc.description.abstract	MicroRNAs (miRNAs), a sub-class of non-coding RNAs approximately 20–24 nucleotides in length, have emerged as valuable biomarkers for disease diagnosis and prognosis, and potential forensic evidence. Advances in lanthanide-doped nanoprobes offer great promise for sensitive miRNA detection due to their high photostability, long luminescence lifetimes, and large anti-Stokes shifts. This review provides a comprehensive overview of strategies for developing lanthanide-doped nanoparticle (LnNP)-based biosensors for miRNA detection. We begin by introducing miRNAs as biomarkers in disease diagnostics and discussing synthesis and surface modification approaches for upconversion nanoprobes. We then highlight various detection strategies using lanthanide-doped nanoprobes—including clustered regularly interspaced short palindromic repeats (CRISPR)-based, sandwich structure-based, energy transfer-based, and inductively coupled plasma (ICP)-based detection. Finally, we address current challenges, potential applications and future perspectives for LnNP-based biosensors and their potential for clinical translation.
dc.language	English
dc.publisher	ELSEVIER SCIENCE SA
dc.relation.ispartof	Coordination Chemistry Reviews
dc.relation.isbasedon	10.1016/j.ccr.2025.216644
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0302 Inorganic Chemistry, 0306 Physical Chemistry (incl. Structural), 0399 Other Chemical Sciences
dc.subject.classification	General Chemistry
dc.subject.classification	3402 Inorganic chemistry
dc.subject.classification	4003 Biomedical engineering
dc.title	Lanthanide-doped nanoprobes for microRNA detection
dc.type	Journal Article
utslib.citation.volume	536
utslib.for	0302 Inorganic Chemistry
utslib.for	0306 Physical Chemistry (incl. Structural)
utslib.for	0399 Other Chemical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Institute of Biomedical Materials and Devices (IBMD)
pubs.organisational-group	University of Technology Sydney/UTS Groups/The Kidman Centre (TKC)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Chancellor's Research Fellows
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2025-09-22T03:57:20Z
pubs.publication-status	Published
pubs.volume	536

Abstract:

MicroRNAs (miRNAs), a sub-class of non-coding RNAs approximately 20–24 nucleotides in length, have emerged as valuable biomarkers for disease diagnosis and prognosis, and potential forensic evidence. Advances in lanthanide-doped nanoprobes offer great promise for sensitive miRNA detection due to their high photostability, long luminescence lifetimes, and large anti-Stokes shifts. This review provides a comprehensive overview of strategies for developing lanthanide-doped nanoparticle (LnNP)-based biosensors for miRNA detection. We begin by introducing miRNAs as biomarkers in disease diagnostics and discussing synthesis and surface modification approaches for upconversion nanoprobes. We then highlight various detection strategies using lanthanide-doped nanoprobes—including clustered regularly interspaced short palindromic repeats (CRISPR)-based, sandwich structure-based, energy transfer-based, and inductively coupled plasma (ICP)-based detection. Finally, we address current challenges, potential applications and future perspectives for LnNP-based biosensors and their potential for clinical translation.

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http://hdl.handle.net/10453/190010