Oxidation of MDMA in urine after exposure to bleach

Pham, AQ; Fu, S; Dawson, M

Oxidation of MDMA in urine after exposure to bleach

Pham, AQ Fu, S

Dawson, M

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Publisher:: GI Printing & Graphics
Publication Type:: Conference Proceeding
Citation:: TIAFT Bulletin, 2011, 41 pp. 49 - 51
Issue Date:: 2011-01

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Field	Value	Language
dc.contributor.author	Pham, AQ	en_US
dc.contributor.author	Fu, S https://orcid.org/0000-0002-6238-3612	en_US
dc.contributor.author	Dawson, M	en_US
dc.contributor.editor	Gerostamoulos, D	en_US
dc.contributor.editor	Beyer, J	en_US
dc.date	2010-08-29	en_US
dc.date.issued	2011-01	en_US
dc.identifier.citation	TIAFT Bulletin, 2011, 41 pp. 49 - 51	en_US
dc.identifier.uri	http://hdl.handle.net/10453/19066
dc.description.abstract	For the drug testing of MDMA (3,4-methylenedioxymethamphetamine or 'ecstasy') and other drugs of abuse, urine is generally the matrix of choice. However, the main issue concerned with urine drug testing is the lack of sample integrity due to acts of urine adulteration. A novel approach in the fight against urine adulteration is researched in this article, involving the use of LC-MS/MS (liquid chromatography-tandem mass spectrometry) to study and identify stable reaction products between the chemical reaction of MDMA and hypochlorite. Samples were analysed on an X Bridge C 18 column ( 150mm x 4.6mm, 3.51-Jm, Waters). Chromatographic separation was achieved at a tlow rate of 0.3ml/min using gradient elution involving 2mM ammonium formate solution in Milli-Q water and acetonitrile as the mobile phases. Kinetic experiments were performed whereby 11-JL of urinary reaction mixture was injected every 30min of reaction. One major reaction product, N-chloroMDMA, was formed and found to be unstable at room temperature (20°C), possibly reverting back into MDMA. It is suggested that bleach may possibly be able to oxidise a low dosage of MDMA to below cutoff concentration values and thus, conceal MDMA use. However, more research is required.	en_US
dc.publisher	GI Printing & Graphics	en_US
dc.relation.ispartof	TIAFT Bulletin	en_US
dc.relation.ispartof	Annual Meeting of the International-Association-of-Forensic-Toxicologists (TIAFT)	en_US
dc.title	Oxidation of MDMA in urine after exposure to bleach	en_US
dc.type	Conference Proceeding
utslib.citation.volume	41	en_US
utslib.location	Australia	en_US
utslib.location.activity	Bonn, Germany	en_US
utslib.for	030499 Medicinal and Biomolecular Chemistry not elsewhere classified	en_US
dc.location.activity	Bonn, Germany	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Chemistry and Forensic Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	closed_access
pubs.consider-herdc	false	en_US
pubs.finish-date	2010-09-02	en_US
pubs.place-of-publication	Australia	en_US
pubs.start-date	2010-08-29	en_US
pubs.volume	41	en_US

Abstract:

For the drug testing of MDMA (3,4-methylenedioxymethamphetamine or 'ecstasy') and other drugs of abuse, urine is generally the matrix of choice. However, the main issue concerned with urine drug testing is the lack of sample integrity due to acts of urine adulteration. A novel approach in the fight against urine adulteration is researched in this article, involving the use of LC-MS/MS (liquid chromatography-tandem mass spectrometry) to study and identify stable reaction products between the chemical reaction of MDMA and hypochlorite. Samples were analysed on an X Bridge C 18 column ( 150mm x 4.6mm, 3.51-Jm, Waters). Chromatographic separation was achieved at a tlow rate of 0.3ml/min using gradient elution involving 2mM ammonium formate solution in Milli-Q water and acetonitrile as the mobile phases. Kinetic experiments were performed whereby 11-JL of urinary reaction mixture was injected every 30min of reaction. One major reaction product, N-chloroMDMA, was formed and found to be unstable at room temperature (20°C), possibly reverting back into MDMA. It is suggested that bleach may possibly be able to oxidise a low dosage of MDMA to below cutoff concentration values and thus, conceal MDMA use. However, more research is required.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/19066