Comparative assessment of antibiofilm and antioxidant activities between curcuma longa silver nano particles and ethanolic extract of curcuma longa

Suwal, N; Bashyal, S; Paudyal, P; Khanal, DP; Suwal, N; Dhaubanjar, S; Thapa, R; Paudel, KR

Comparative assessment of antibiofilm and antioxidant activities between curcuma longa silver nano particles and ethanolic extract of curcuma longa

Suwal, N Bashyal, S Paudyal, P Khanal, DP Suwal, N Dhaubanjar, S Thapa, R Paudel, KR

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Next Research, 2025, 2, (3), pp. 100447
Issue Date:: 2025-09

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Field	Value	Language
dc.contributor.author	Suwal, N
dc.contributor.author	Bashyal, S
dc.contributor.author	Paudyal, P
dc.contributor.author	Khanal, DP
dc.contributor.author	Suwal, N
dc.contributor.author	Dhaubanjar, S
dc.contributor.author	Thapa, R
dc.contributor.author	Paudel, KR
dc.date.accessioned	2026-01-06T04:05:19Z
dc.date.available	2026-01-06T04:05:19Z
dc.date.issued	2025-09
dc.identifier.citation	Next Research, 2025, 2, (3), pp. 100447
dc.identifier.issn	3050-4759
dc.identifier.uri	http://hdl.handle.net/10453/191321
dc.description.abstract	Biofilms demonstrate multidrug resistance and present challenges for therapies. Notably, organisms like Staphylococcus aureus and Pseudomonas aeruginosa are major contributors to biofilm-related infections. Various strategies are employed to address antibiotic resistance vulnerabilities. Researchers are investigating the potential of plants and phytochemicals to overcome these challenges, with green nanosynthesis emerging as a promising strategy against antibiotic resistance. Turmeric (Curcuma longa) is a commonly used spice valued for its potent medicinal properties, such as antibacterial, anti-inflammatory, antioxidant, and anti-biofilm activities. This study encompasses the ethanolic extraction of Curcuma longa (C. longaE) and the qualitative identification of its constituents using Thin Layer Chromatography (TLC) and Gas Chromatography-Mass Spectrometry (GC–MS). Additionally, it also includes the synthesis and characterization of Curcuma longa silver nanoparticles (C. longaAgNPs), along with a comparative assessment of the antioxidant and antibiofilm activities of C. longaE and C. longaAgNPs. The TLC and GCMS– results show the presence of curcuminoids, Ar-tumerone, and curlone as major constituents in C. longaE. The C. longaAgNPs were characterized by Ultraviolet (UV) Spectroscopy, Fourier Transform Infrared Radiation (FTIR), X-ray Diffraction (XRD), and DLS analysis. The DLS analysis shows that C. longaAgNPs had a hydrodynamic diameter of 153 ± 0.75 nm and a polydispersity index (PDI) of 0.199 ± 0.0043. The IC50 value for the antioxidant activity of C. longaAgNPs was significantly lower at 19.972 ± 0.148 µg/ml when compared with the C. longaE, which measured 63.262 ± 0.928 µg/ml. The IC50 values for the antibiofilm activity of C. longaAgNPs were significantly lower at 0.1963 ± 0.0120 mg/ml for P. aeruginosa and 0.1681 ± 0.0259 mg/ml for S. aureus compared to the IC50 values of C. longaE, which measured 2.043 ± 0.0831 mg/ml and 0.8758 ± 0.0325 mg/ml, respectively. The C. longaAgNPs show significantly higher antioxidant and antibiofilm properties than C. longaE.
dc.language	en
dc.publisher	Elsevier
dc.relation.ispartof	Next Research
dc.relation.isbasedon	10.1016/j.nexres.2025.100447
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Comparative assessment of antibiofilm and antioxidant activities between curcuma longa silver nano particles and ethanolic extract of curcuma longa
dc.type	Journal Article
utslib.citation.volume	2
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Inflammation (CFI)
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2026-01-06T04:05:17Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	2
utslib.citation.issue	3

Abstract:

Biofilms demonstrate multidrug resistance and present challenges for therapies. Notably, organisms like Staphylococcus aureus and Pseudomonas aeruginosa are major contributors to biofilm-related infections. Various strategies are employed to address antibiotic resistance vulnerabilities. Researchers are investigating the potential of plants and phytochemicals to overcome these challenges, with green nanosynthesis emerging as a promising strategy against antibiotic resistance. Turmeric (Curcuma longa) is a commonly used spice valued for its potent medicinal properties, such as antibacterial, anti-inflammatory, antioxidant, and anti-biofilm activities. This study encompasses the ethanolic extraction of Curcuma longa (C. longaE) and the qualitative identification of its constituents using Thin Layer Chromatography (TLC) and Gas Chromatography-Mass Spectrometry (GC–MS). Additionally, it also includes the synthesis and characterization of Curcuma longa silver nanoparticles (C. longaAgNPs), along with a comparative assessment of the antioxidant and antibiofilm activities of C. longaE and C. longaAgNPs. The TLC and GCMS– results show the presence of curcuminoids, Ar-tumerone, and curlone as major constituents in C. longaE. The C. longaAgNPs were characterized by Ultraviolet (UV) Spectroscopy, Fourier Transform Infrared Radiation (FTIR), X-ray Diffraction (XRD), and DLS analysis. The DLS analysis shows that C. longaAgNPs had a hydrodynamic diameter of 153 ± 0.75 nm and a polydispersity index (PDI) of 0.199 ± 0.0043. The IC50 value for the antioxidant activity of C. longaAgNPs was significantly lower at 19.972 ± 0.148 µg/ml when compared with the C. longaE, which measured 63.262 ± 0.928 µg/ml. The IC50 values for the antibiofilm activity of C. longaAgNPs were significantly lower at 0.1963 ± 0.0120 mg/ml for P. aeruginosa and 0.1681 ± 0.0259 mg/ml for S. aureus compared to the IC50 values of C. longaE, which measured 2.043 ± 0.0831 mg/ml and 0.8758 ± 0.0325 mg/ml, respectively. The C. longaAgNPs show significantly higher antioxidant and antibiofilm properties than C. longaE.

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http://hdl.handle.net/10453/191321