Evolution of the cytoskeleton: Emerging clues from the diversification and specialisation of archaeal cytoskeletal proteins.

Brown, HJ; Shinde, VD; Bosi, L; Duggin, IG

Evolution of the cytoskeleton: Emerging clues from the diversification and specialisation of archaeal cytoskeletal proteins.

Brown, HJ Shinde, VD Bosi, L Duggin, IG

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Publisher:: CURRENT BIOLOGY LTD
Publication Type:: Journal Article
Citation:: Curr Opin Cell Biol, 2025, 95, pp. 102557
Issue Date:: 2025-08

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Field	Value	Language
dc.contributor.author	Brown, HJ
dc.contributor.author	Shinde, VD
dc.contributor.author	Bosi, L
dc.contributor.author	Duggin, IG
dc.date.accessioned	2026-01-06T05:44:42Z
dc.date.available	2025-05-19
dc.date.available	2026-01-06T05:44:42Z
dc.date.issued	2025-08
dc.identifier.citation	Curr Opin Cell Biol, 2025, 95, pp. 102557
dc.identifier.issn	0955-0674
dc.identifier.issn	1879-0410
dc.identifier.uri	http://hdl.handle.net/10453/191348
dc.description.abstract	Recent research in archaeal cell biology has revealed a remarkable diversity of cytoskeletal proteins related to those found in bacteria and eukaryotes, such as the tubulin, actin, and ESCRT protein superfamilies, and archaea-specific proteins that self-assemble and have been implicated in cytoskeletal roles. Here, we outline an emerging view that the archaeal cytoskeleton has several conceptual ties to the sophisticated eukaryotic cytoskeleton. We highlight that duplication and specialisation of protein function is common among archaeal cytoskeletal systems, and that some paralogues show coordinated, opposing functions in the regulation of cell morphogenesis and structural homeostasis. Furthermore, the presence of homologues of eukaryotic cytoskeletal regulators in Asgard archaea, the closest known relatives of eukaryotes, underscores further linkages between eukaryotic and increasingly sophisticated archaeal cytoskeletal systems.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	CURRENT BIOLOGY LTD
dc.relation.ispartof	Curr Opin Cell Biol
dc.relation.isbasedon	10.1016/j.ceb.2025.102557
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0601 Biochemistry and Cell Biology
dc.subject.classification	Developmental Biology
dc.subject.classification	3101 Biochemistry and cell biology
dc.subject.mesh	Archaea
dc.subject.mesh	Evolution, Molecular
dc.subject.mesh	Cytoskeleton
dc.subject.mesh	Cytoskeletal Proteins
dc.subject.mesh	Endosomal Sorting Complexes Required for Transport
dc.subject.mesh	Archaeal Proteins
dc.subject.mesh	Cytoskeleton
dc.subject.mesh	Archaea
dc.subject.mesh	Archaeal Proteins
dc.subject.mesh	Cytoskeletal Proteins
dc.subject.mesh	Evolution, Molecular
dc.subject.mesh	Endosomal Sorting Complexes Required for Transport
dc.subject.mesh	Archaea
dc.subject.mesh	Evolution, Molecular
dc.subject.mesh	Cytoskeleton
dc.subject.mesh	Cytoskeletal Proteins
dc.subject.mesh	Endosomal Sorting Complexes Required for Transport
dc.subject.mesh	Archaeal Proteins
dc.title	Evolution of the cytoskeleton: Emerging clues from the diversification and specialisation of archaeal cytoskeletal proteins.
dc.type	Journal Article
utslib.citation.volume	95
utslib.location.activity	England
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Australian Institute for Microbiology & Infection (AIMI)
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2026-01-06T05:44:40Z
pubs.publication-status	Published
pubs.volume	95

Abstract:

Recent research in archaeal cell biology has revealed a remarkable diversity of cytoskeletal proteins related to those found in bacteria and eukaryotes, such as the tubulin, actin, and ESCRT protein superfamilies, and archaea-specific proteins that self-assemble and have been implicated in cytoskeletal roles. Here, we outline an emerging view that the archaeal cytoskeleton has several conceptual ties to the sophisticated eukaryotic cytoskeleton. We highlight that duplication and specialisation of protein function is common among archaeal cytoskeletal systems, and that some paralogues show coordinated, opposing functions in the regulation of cell morphogenesis and structural homeostasis. Furthermore, the presence of homologues of eukaryotic cytoskeletal regulators in Asgard archaea, the closest known relatives of eukaryotes, underscores further linkages between eukaryotic and increasingly sophisticated archaeal cytoskeletal systems.

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http://hdl.handle.net/10453/191348