Preclinical research models for evaluating the biocompatibility of bioresorbable metallic cardiovascular stents: A comparative review.

Hansen, S; Bui, TA; Xu, X; McGrath, K

Preclinical research models for evaluating the biocompatibility of bioresorbable metallic cardiovascular stents: A comparative review.

Hansen, S Bui, TA Xu, X

McGrath, K

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Publisher:: KEAI PUBLISHING LTD
Publication Type:: Journal Article
Citation:: Bioact Mater, 2025, 54, pp. 871-885
Issue Date:: 2025-12

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Field	Value	Language
dc.contributor.author	Hansen, S
dc.contributor.author	Bui, TA
dc.contributor.author	Xu, X https://orcid.org/0000-0002-0444-5643
dc.contributor.author	McGrath, K https://orcid.org/0000-0002-6244-3929
dc.date.accessioned	2026-01-07T02:58:58Z
dc.date.available	2025-09-03
dc.date.available	2026-01-07T02:58:58Z
dc.date.issued	2025-12
dc.identifier.citation	Bioact Mater, 2025, 54, pp. 871-885
dc.identifier.issn	2452-199X
dc.identifier.issn	2452-199X
dc.identifier.uri	http://hdl.handle.net/10453/191415
dc.description.abstract	Cardiovascular stents are widely used to treat atherosclerosis by relieving vascular obstruction and providing structural support after coronary angioplasty. Bioresorbable metallic stents represent a promising alternative to conventional corrosion-resistant stents, which are linked to late-stage complications such as in-stent restenosis and thrombosis. Due to the diversity of stent materials and designs, rigorous evaluation of their interactions with the vascular environment in relevant preclinical models is essential before clinical translation. However, current studies employ highly variable in vitro cell systems, in vivo animal models, and experimental assays to assess biocompatibility, making it difficult to draw definitive conclusions about candidate designs. This review outlines the current landscape of bioresorbable metallic stents, critically examines the strengths and limitations of preclinical models described in the literature and in international guidelines, and provides recommendations to guide future research in this rapidly evolving field.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	KEAI PUBLISHING LTD
dc.relation.ispartof	Bioact Mater
dc.relation.isbasedon	10.1016/j.bioactmat.2025.09.004
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	3404 Medicinal and biomolecular chemistry
dc.subject.classification	4003 Biomedical engineering
dc.subject.classification	4016 Materials engineering
dc.title	Preclinical research models for evaluating the biocompatibility of bioresorbable metallic cardiovascular stents: A comparative review.
dc.type	Journal Article
utslib.citation.volume	54
utslib.location.activity	China
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Climate Change & Health Research Collaborative (CCHRC)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Women & Children’s Health Research Collaborative (WCHC)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Health Technologies (CHT)
pubs.organisational-group	University of Technology Sydney/Faculty of Science/Science Related HDR Students
pubs.organisational-group	University of Technology Sydney/UTS Groups/Chancellor's Research Fellows
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2026-01-07T02:58:55Z
pubs.publication-status	Published online
pubs.volume	54

Abstract:

Cardiovascular stents are widely used to treat atherosclerosis by relieving vascular obstruction and providing structural support after coronary angioplasty. Bioresorbable metallic stents represent a promising alternative to conventional corrosion-resistant stents, which are linked to late-stage complications such as in-stent restenosis and thrombosis. Due to the diversity of stent materials and designs, rigorous evaluation of their interactions with the vascular environment in relevant preclinical models is essential before clinical translation. However, current studies employ highly variable in vitro cell systems, in vivo animal models, and experimental assays to assess biocompatibility, making it difficult to draw definitive conclusions about candidate designs. This review outlines the current landscape of bioresorbable metallic stents, critically examines the strengths and limitations of preclinical models described in the literature and in international guidelines, and provides recommendations to guide future research in this rapidly evolving field.

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http://hdl.handle.net/10453/191415