Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in mice.

Wang, X; Zeng, C; Wu, Z; Lu, M; Wang, X; Xiu, Y; Wang, Q; Wang, S; Chen, X; Shen, Y; Li, H; Su, Y; Chen, P; Chen, H; Sheng, N; Mo, W; Yi, C; Yang, Q; Verkhratsky, A; Niu, J; Xiao, L

Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in mice.

Wang, X Zeng, C Wu, Z Lu, M Wang, X Xiu, Y Wang, Q Wang, S Chen, X Shen, Y Li, H Su, Y Chen, P Chen, H

Sheng, N Mo, W Yi, C Yang, Q Verkhratsky, A Niu, J Xiao, L

Permalink

Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: Nat Commun, 2025
Issue Date:: 2025-12-21

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Accepted versionAdobe PDF (4.77 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Wang, X
dc.contributor.author	Zeng, C
dc.contributor.author	Wu, Z
dc.contributor.author	Lu, M
dc.contributor.author	Wang, X
dc.contributor.author	Xiu, Y
dc.contributor.author	Wang, Q
dc.contributor.author	Wang, S
dc.contributor.author	Chen, X
dc.contributor.author	Shen, Y
dc.contributor.author	Li, H
dc.contributor.author	Su, Y
dc.contributor.author	Chen, P
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752
dc.contributor.author	Sheng, N
dc.contributor.author	Mo, W
dc.contributor.author	Yi, C
dc.contributor.author	Yang, Q
dc.contributor.author	Verkhratsky, A
dc.contributor.author	Niu, J
dc.contributor.author	Xiao, L
dc.date.accessioned	2026-01-08T02:34:26Z
dc.date.available	2025-12-12
dc.date.available	2026-01-08T02:34:26Z
dc.date.issued	2025-12-21
dc.identifier.citation	Nat Commun, 2025
dc.identifier.issn	2041-1723
dc.identifier.issn	2041-1723
dc.identifier.uri	http://hdl.handle.net/10453/191491
dc.description.abstract	Autism spectrum disorders (ASD) are neurodevelopmental disorders associated with synaptic deficits. Oligodendrocyte precursor cells (OPCs) are the only type of glial cells that establish direct synaptic connections with neurons within the central nervous system (CNS). However, the mechanism that results in the delicate construction of OPC-neuron synaptic connections remain poorly understood. Here we show in a mouse model that BAF155, a chromatin remodeling factor, is highly expressed in committed OPCs. BAF155 influences the OPC differentiation and myelination by coordinating the expression of multiple synapse-related genes that mediate OPC-neuron synaptic communication. The varying chromatin regulatory roles of BAF155 across brain regions give rise to local myelin deficits, contributing to the diverse clinical manifestations observed in individuals with ASD. Collectively, these results deepen our insight into OPC-neuron interactions under pathophysiological conditions and uncover a mechanism that integrates synaptic and ASD susceptibility genes, implying that abnormal OPC-neuron synaptogenesis could be an early instigator of ASD.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	Nat Commun
dc.relation.isbasedon	10.1038/s41467-025-67930-y
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in mice.
dc.type	Journal Article
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Women & Children’s Health Research Collaborative (WCHC)
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated	2026-01-08T02:34:24Z
pubs.publication-status	Published online

Abstract:

Autism spectrum disorders (ASD) are neurodevelopmental disorders associated with synaptic deficits. Oligodendrocyte precursor cells (OPCs) are the only type of glial cells that establish direct synaptic connections with neurons within the central nervous system (CNS). However, the mechanism that results in the delicate construction of OPC-neuron synaptic connections remain poorly understood. Here we show in a mouse model that BAF155, a chromatin remodeling factor, is highly expressed in committed OPCs. BAF155 influences the OPC differentiation and myelination by coordinating the expression of multiple synapse-related genes that mediate OPC-neuron synaptic communication. The varying chromatin regulatory roles of BAF155 across brain regions give rise to local myelin deficits, contributing to the diverse clinical manifestations observed in individuals with ASD. Collectively, these results deepen our insight into OPC-neuron interactions under pathophysiological conditions and uncover a mechanism that integrates synaptic and ASD susceptibility genes, implying that abnormal OPC-neuron synaptogenesis could be an early instigator of ASD.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/191491