Beyond conventional biomarkers: Emerging importance of extracellular vesicles in osteoarthritis, metabolic disorders and cardiovascular disease

Coward-Smith, M; Zhang, Y; Donovan, C; Kim, RY; Wang, B; Zakarya, R; Chen, H; Li, JJ; Oliver, BG

Beyond conventional biomarkers: Emerging importance of extracellular vesicles in osteoarthritis, metabolic disorders and cardiovascular disease

Coward-Smith, M

Zhang, Y

Donovan, C

Kim, RY Wang, B Zakarya, R

Chen, H

Li, JJ Oliver, BG

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Extracellular Vesicle, 2025, 5, pp. 100079
Issue Date:: 2025-06-01

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Field	Value	Language
dc.contributor.author	Coward-Smith, M https://orcid.org/0000-0002-5362-8577
dc.contributor.author	Zhang, Y https://orcid.org/0000-0002-6244-1173
dc.contributor.author	Donovan, C https://orcid.org/0000-0003-4558-329X
dc.contributor.author	Kim, RY
dc.contributor.author	Wang, B
dc.contributor.author	Zakarya, R https://orcid.org/0000-0002-9259-9369
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752
dc.contributor.author	Li, JJ
dc.contributor.author	Oliver, BG
dc.date.accessioned	2026-01-08T02:48:30Z
dc.date.available	2026-01-08T02:48:30Z
dc.date.issued	2025-06-01
dc.identifier.citation	Extracellular Vesicle, 2025, 5, pp. 100079
dc.identifier.issn	2773-0417
dc.identifier.issn	2773-0417
dc.identifier.uri	http://hdl.handle.net/10453/191497
dc.description.abstract	Extracellular vesicles (EVs), initially recognized for their roles in intercellular communication, are being increasingly explored for applications in the diagnosis and therapy of various diseases, particularly those driven by chronic inflammation. This review provides insight into the defining characteristics and functions of EVs, focusing on their role in contributing to and acting as potential therapeutics for chronic inflammatory diseases, including osteoarthritis, metabolic disorders such as obesity and metabolic dysfunction associated fatty liver disease, and cardiovascular diseases such as atherosclerosis and ischaemic stroke. Finally, the issues limiting EV translation from bench to bedside, and the outlook of EV research are discussed.
dc.language	en
dc.publisher	Elsevier
dc.relation.ispartof	Extracellular Vesicle
dc.relation.isbasedon	10.1016/j.vesic.2025.100079
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Beyond conventional biomarkers: Emerging importance of extracellular vesicles in osteoarthritis, metabolic disorders and cardiovascular disease
dc.type	Journal Article
utslib.citation.volume	5
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	University of Technology Sydney/UTS Groups
pubs.organisational-group	University of Technology Sydney/UTS Groups/Women & Children’s Health Research Collaborative (WCHC)
pubs.organisational-group	University of Technology Sydney/UTS Groups/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2026-01-08T02:48:28Z
pubs.publication-status	Published
pubs.volume	5

Abstract:

Extracellular vesicles (EVs), initially recognized for their roles in intercellular communication, are being increasingly explored for applications in the diagnosis and therapy of various diseases, particularly those driven by chronic inflammation. This review provides insight into the defining characteristics and functions of EVs, focusing on their role in contributing to and acting as potential therapeutics for chronic inflammatory diseases, including osteoarthritis, metabolic disorders such as obesity and metabolic dysfunction associated fatty liver disease, and cardiovascular diseases such as atherosclerosis and ischaemic stroke. Finally, the issues limiting EV translation from bench to bedside, and the outlook of EV research are discussed.

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http://hdl.handle.net/10453/191497