Understanding Bacterial Evolution and Adaptation in Natural Microbial Environments

Krishnan, Sidaswar

Understanding Bacterial Evolution and Adaptation in Natural Microbial Environments

Krishnan, Sidaswar

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Publication Type:: Thesis
Issue Date:: 2025

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Field	Value	Language
dc.contributor.author	Krishnan, Sidaswar
dc.date.accessioned	2026-03-25T03:47:25Z
dc.date.available	2026-03-25T03:47:25Z
dc.date.issued	2025
dc.identifier.uri	http://hdl.handle.net/10453/194447
dc.description	University of Technology Sydney. Faculty of Science.	en_US.UTF-8
dc.description.abstract	Microbial evolution is underpinned by the processes of mutation and recombination, yet the dynamics of these processes within natural microbiomes remain poorly characterised. The growing application of metagenomics to study prokaryotes in their native habitats presents an excellent opportunity for learning more about recombination and mutation. However, a major bottleneck relates to the paucity of tools that can precisely measure recombination and mutation rates using next-generation sequencing datasets. This thesis has delivered a new tool for quantifying mutation and recombination rates from metagenomic datasets, which has opened the door to understanding these important evolutionary forces in natural microbiomes. Using this new tool, I was able to demonstrate the heterogeneous dynamics of recombination and mutation within the marine microbiome for key bacteria on both local and global scales. This work highlighted the complex interplay between evolutionary processes and environmental conditions that shape marine bacterioplankton communities.	en_US.UTF-8
dc.format	Thesis (PhD)
dc.language.iso	en_US	en_US.UTF-8
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/194447/1/thesis.pdf
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	© 2025 Sidaswar Krishnan
dc.rights	au.edu.uts.lib/cph
dc.title	Understanding Bacterial Evolution and Adaptation in Natural Microbial Environments	en_US.UTF-8
dc.type	Thesis
utslib.copyright.status	open_access	*

Abstract:

Microbial evolution is underpinned by the processes of mutation and recombination, yet the dynamics of these processes within natural microbiomes remain poorly characterised. The growing application of metagenomics to study prokaryotes in their native habitats presents an excellent opportunity for learning more about recombination and mutation. However, a major bottleneck relates to the paucity of tools that can precisely measure recombination and mutation rates using next-generation sequencing datasets. This thesis has delivered a new tool for quantifying mutation and recombination rates from metagenomic datasets, which has opened the door to understanding these important evolutionary forces in natural microbiomes. Using this new tool, I was able to demonstrate the heterogeneous dynamics of recombination and mutation within the marine microbiome for key bacteria on both local and global scales. This work highlighted the complex interplay between evolutionary processes and environmental conditions that shape marine bacterioplankton communities.

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http://hdl.handle.net/10453/194447