The application of immunological assays for the monitoring and diagnosis of selected infectious diseases with particular emphasis on neosporosis

Reichel, MP

The application of immunological assays for the monitoring and diagnosis of selected infectious diseases with particular emphasis on neosporosis

Reichel, MP

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Publication Type:: Thesis
Issue Date:: 2002

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Field	Value	Language
dc.contributor.author	Reichel, MP
dc.date.accessioned	2010-01-22T05:33:50Z
dc.date.accessioned	2012-12-15T03:52:09Z
dc.date.available	2010-01-22T05:33:50Z
dc.date.available	2012-12-15T03:52:09Z
dc.date.issued	2002
dc.identifier.uri	http://hdl.handle.net/10453/20112
dc.description	University of Technology, Sydney. Faculty of Science.
dc.description.abstract	The 16 publications presented in this thesis summarise the author’s contribution to seroepidemiological approaches for the diagnosis and monitoring of animal diseases of importance to New Zealand. The first four publications not only contribute to the above in relation to three important animal pathogens, namely Brucella ovis, Mycobacterium avium spp. paratuberculosis and Bovine Leukaemia Virus but also give an insight into more general consideration associated with the optimisation and validation of serological assays, namely regarding the definition and choice of gold standard reference sera, the determination of the cutoff threshold and discrimination between negative and positive reference populations. Two further publications deal with the establishment and validation of serological assays for the diagnosis of Neospora caninum infection and abortion in New Zealand. Then, baseline data were obtained for the sero-prevalence of the infection in dog and cattle populations in New Zealand. Three case studies provided initially information about the kinetics of serological responses after a N caninum abortion outbreak, and information about the usefulness of herd-based techniques rather than individual cowbased abortion diagnoses. A further study provided some early information about the mode of transmission seemingly predominating in New Zealand, which tends to be mainly via post-natal infection, in contrast to evidence provided by overseas researchers. A final case study, a longitudinal study of serological and other responses over a period of three years also provided data on the production effects of N caninum. The dissertation is completed by a number of reviews on sero-diagnosis of N caninum infection, its presence in Australasia and suggests finally control options, based on the present state of knowledge.	en
dc.format	Thesis (PhD)	en
dc.language.iso	en	en
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/20112/2/02Whole.pdf
dc.relation.replaces	http://hdl.handle.net/2100/986
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	au.edu.uts.lib/ppc
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Neospora caninum.	en
dc.subject	Immunology.	en
dc.subject	Epidemiology.	en
dc.subject	Cattle.	en
dc.subject	Diagnosis.	en
dc.title	The application of immunological assays for the monitoring and diagnosis of selected infectious diseases with particular emphasis on neosporosis	en
dc.type	Thesis
utslib.copyright.status	open_access

Abstract:

The 16 publications presented in this thesis summarise the author’s contribution to seroepidemiological approaches for the diagnosis and monitoring of animal diseases of importance to New Zealand. The first four publications not only contribute to the above in relation to three important animal pathogens, namely Brucella ovis, Mycobacterium avium spp. paratuberculosis and Bovine Leukaemia Virus but also give an insight into more general consideration associated with the optimisation and validation of serological assays, namely regarding the definition and choice of gold standard reference sera, the determination of the cutoff threshold and discrimination between negative and positive reference populations. Two further publications deal with the establishment and validation of serological assays for the diagnosis of Neospora caninum infection and abortion in New Zealand. Then, baseline data were obtained for the sero-prevalence of the infection in dog and cattle populations in New Zealand. Three case studies provided initially information about the kinetics of serological responses after a N caninum abortion outbreak, and information about the usefulness of herd-based techniques rather than individual cowbased abortion diagnoses. A further study provided some early information about the mode of transmission seemingly predominating in New Zealand, which tends to be mainly via post-natal infection, in contrast to evidence provided by overseas researchers. A final case study, a longitudinal study of serological and other responses over a period of three years also provided data on the production effects of N caninum. The dissertation is completed by a number of reviews on sero-diagnosis of N caninum infection, its presence in Australasia and suggests finally control options, based on the present state of knowledge.

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http://hdl.handle.net/10453/20112