The EPIIC hypothesis: Intrapartum effects on the neonatal epigenome and consequent health outcomes

Dahlen, HG; Kennedy, HP; Anderson, CM; Bell, AF; Clark, A; Foureur, M; Ohm, JE; Shearman, AM; Taylor, JY; Wright, ML; Downe, S

The EPIIC hypothesis: Intrapartum effects on the neonatal epigenome and consequent health outcomes

Dahlen, HG

Kennedy, HP Anderson, CM Bell, AF Clark, A Foureur, M

Ohm, JE Shearman, AM Taylor, JY Wright, ML Downe, S

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Publication Type:: Journal Article
Citation:: Medical Hypotheses, 2013, 80 (5), pp. 656 - 662
Issue Date:: 2013-05-01

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Field	Value	Language
dc.contributor.author	Dahlen, HG https://orcid.org/0000-0002-4450-3078	en_US
dc.contributor.author	Kennedy, HP	en_US
dc.contributor.author	Anderson, CM	en_US
dc.contributor.author	Bell, AF	en_US
dc.contributor.author	Clark, A	en_US
dc.contributor.author	Foureur, M https://orcid.org/0000-0002-0454-0165	en_US
dc.contributor.author	Ohm, JE	en_US
dc.contributor.author	Shearman, AM	en_US
dc.contributor.author	Taylor, JY	en_US
dc.contributor.author	Wright, ML	en_US
dc.contributor.author	Downe, S	en_US
dc.date.available	2013-01-14	en_US
dc.date.issued	2013-05-01	en_US
dc.identifier.citation	Medical Hypotheses, 2013, 80 (5), pp. 656 - 662	en_US
dc.identifier.issn	0306-9877	en_US
dc.identifier.uri	http://hdl.handle.net/10453/23965
dc.description.abstract	There are many published studies about the epigenetic effects of the prenatal and infant periods on health outcomes. However, there is very little knowledge regarding the effects of the intrapartum period (labor and birth) on health and epigenetic remodeling. Although the intrapartum period is relatively short compared to the complete perinatal period, there is emerging evidence that this time frame may be a critical formative phase for the human genome. Given the debates from the National Institutes of Health and World Health Organization regarding routine childbirth procedures, it is essential to establish the state of the science concerning normal intrapartum epigenetic physiology. EPIIC (Epigenetic Impact of Childbirth) is an international, interdisciplinary research collaboration with expertise in the fields of genetics, physiology, developmental biology, epidemiology, medicine, midwifery, and nursing. We hypothesize that events during the intrapartum period - specifically the use of synthetic oxytocin, antibiotics, and cesarean section - affect the epigenetic remodeling processes and subsequent health of the mother and offspring. The rationale for this hypothesis is based on recent evidence and current best practice. © 2013 Elsevier Ltd.	en_US
dc.relation.ispartof	Medical Hypotheses	en_US
dc.relation.isbasedon	10.1016/j.mehy.2013.01.017	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Infant, Newborn, Diseases	en_US
dc.subject.mesh	Cesarean Section	en_US
dc.subject.mesh	Epigenesis, Genetic	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Labor, Obstetric	en_US
dc.subject.mesh	Models, Genetic	en_US
dc.subject.mesh	Infant, Newborn	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Epigenomics	en_US
dc.title	The EPIIC hypothesis: Intrapartum effects on the neonatal epigenome and consequent health outcomes	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	80	en_US
utslib.for	1117 Public Health and Health Services	en_US
utslib.for	1110 Nursing	en_US
utslib.for	11 Medical and Health Sciences	en_US
dc.location.activity	Auckland, New Zealand
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Midwifery
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	80	en_US

Abstract:

There are many published studies about the epigenetic effects of the prenatal and infant periods on health outcomes. However, there is very little knowledge regarding the effects of the intrapartum period (labor and birth) on health and epigenetic remodeling. Although the intrapartum period is relatively short compared to the complete perinatal period, there is emerging evidence that this time frame may be a critical formative phase for the human genome. Given the debates from the National Institutes of Health and World Health Organization regarding routine childbirth procedures, it is essential to establish the state of the science concerning normal intrapartum epigenetic physiology. EPIIC (Epigenetic Impact of Childbirth) is an international, interdisciplinary research collaboration with expertise in the fields of genetics, physiology, developmental biology, epidemiology, medicine, midwifery, and nursing. We hypothesize that events during the intrapartum period - specifically the use of synthetic oxytocin, antibiotics, and cesarean section - affect the epigenetic remodeling processes and subsequent health of the mother and offspring. The rationale for this hypothesis is based on recent evidence and current best practice. © 2013 Elsevier Ltd.

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http://hdl.handle.net/10453/23965