Donor age is a major determinant of success of oocyte donation/recipient programme

Wang, YA; Farquhar, C; Sullivan, EA

Donor age is a major determinant of success of oocyte donation/recipient programme

Wang, YA

Farquhar, C Sullivan, EA

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Publication Type:: Journal Article
Citation:: Human Reproduction, 2012, 27 (1), pp. 118 - 125
Issue Date:: 2012-01-01

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Field	Value	Language
dc.contributor.author	Wang, YA https://orcid.org/0000-0002-3656-4284	en_US
dc.contributor.author	Farquhar, C	en_US
dc.contributor.author	Sullivan, EA https://orcid.org/0000-0002-8718-2753	en_US
dc.date.issued	2012-01-01	en_US
dc.identifier.citation	Human Reproduction, 2012, 27 (1), pp. 118 - 125	en_US
dc.identifier.issn	0268-1161	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28651
dc.description.abstract	BACKGROUND: In recent years, particularly in developed countries, women have tended to delay childbirth until over 40 years of age. Our study aims to identify whether the donors age or recipients age influences the pregnancy and live birth rate following oocyte recipient cycles. METHODS: A population study included 3889 fresh oocyte recipient cycles. Pregnancy and live delivery rates were compared in recipient age groups (<35, 3539, 4044 and <45 years) and donor age groups (<30, 3034, 3539 and <40 years). RESULTS: The highest live birth rate was of cycles in donors aged 3034 years (25.0), it decreased (P< 0.05) to 24.1 in donors aged <30 years, 20.7 in donors aged 3539 years and 11.5 in donors aged <40 years. The multivariate analysis showed no significant differences in the success by recipients age. Compared with cycles in donors aged 3034 years, cycles in donors aged 3539 years had 14 and 18 less chance to achieve a pregnancy [adjusted rate ratio (ARR) 0.86, 95 confidence interval (CI) 0.750.98] and a live delivery (ARR 0.82, 95 CI 0.710.96), while cycles in donors aged 40 years or older had 42 and 54 less chance to achieve a pregnancy (ARR 0.58, 95 CI 0.410.84) and a live delivery (ARR 0.46, 95 CI 0.290.73). CONCLUSIONS: Older recipients with younger donors did not have a poorer pregnancy outcome compared with younger recipients with younger donors. Choosing a donor aged <35 years would increase the chance of pregnancy and live delivery for older recipients. © The Author 2011.	en_US
dc.relation.ispartof	Human Reproduction	en_US
dc.relation.isbasedon	10.1093/humrep/der359	en_US
dc.subject.classification	Obstetrics & Reproductive Medicine	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Pregnancy Outcome	en_US
dc.subject.mesh	Reproductive Techniques, Assisted	en_US
dc.subject.mesh	Oocyte Donation	en_US
dc.subject.mesh	Pregnancy Rate	en_US
dc.subject.mesh	Age Factors	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Tissue Donors	en_US
dc.subject.mesh	Female	en_US
dc.title	Donor age is a major determinant of success of oocyte donation/recipient programme	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	27	en_US
utslib.for	1117 Public Health and Health Services	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	16 Studies in Human Society	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	27	en_US

Abstract:

BACKGROUND: In recent years, particularly in developed countries, women have tended to delay childbirth until over 40 years of age. Our study aims to identify whether the donors age or recipients age influences the pregnancy and live birth rate following oocyte recipient cycles. METHODS: A population study included 3889 fresh oocyte recipient cycles. Pregnancy and live delivery rates were compared in recipient age groups (<35, 3539, 4044 and <45 years) and donor age groups (<30, 3034, 3539 and <40 years). RESULTS: The highest live birth rate was of cycles in donors aged 3034 years (25.0), it decreased (P< 0.05) to 24.1 in donors aged <30 years, 20.7 in donors aged 3539 years and 11.5 in donors aged <40 years. The multivariate analysis showed no significant differences in the success by recipients age. Compared with cycles in donors aged 3034 years, cycles in donors aged 3539 years had 14 and 18 less chance to achieve a pregnancy [adjusted rate ratio (ARR) 0.86, 95 confidence interval (CI) 0.750.98] and a live delivery (ARR 0.82, 95 CI 0.710.96), while cycles in donors aged 40 years or older had 42 and 54 less chance to achieve a pregnancy (ARR 0.58, 95 CI 0.410.84) and a live delivery (ARR 0.46, 95 CI 0.290.73). CONCLUSIONS: Older recipients with younger donors did not have a poorer pregnancy outcome compared with younger recipients with younger donors. Choosing a donor aged <35 years would increase the chance of pregnancy and live delivery for older recipients. © The Author 2011.

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http://hdl.handle.net/10453/28651