Formulation and characterization of poloxamer 407: thermoreversible gel containing polymeric microparticles and hyaluronic acid

Sociedade Brazileira de Quimica
Publication Type:
Journal Article
Quim. Nova, 2013, 36 (8), pp. 1121 - 1125
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The influence of the composition and preparation method on the solgel transition temperature (Tsolgel) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of Tsolgel on the poloxamer content was observed in the range of concentrations analyzed, and a Poloxamer 407® concentration of 18% was selected. The addition of hyaluronic acid did not lead to significant changes in the Tsolgel values. In contrast, the addition of microparticles caused a reduction in Tsolgel without a significant reduction in gel strength, and pseudoplastic characteristics were observed, indicating that a thermoreversible gel was obtained with a rheology suitable for application in the treatment of burn wounds.
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