Combinatorial synthesis of SSAO inhibitors using sonogashira coupling: SAR of aryl propargylic amines
- Publication Type:
- Journal Article
- Citation:
- Bioorganic and Medicinal Chemistry Letters, 2001, 11 (19), pp. 2565 - 2568
- Issue Date:
- 2001-10-08
Closed Access
Filename | Description | Size | |||
---|---|---|---|---|---|
2004004617.pdf | 306.45 kB |
Copyright Clearance Process
- Recently Added
- In Progress
- Closed Access
This item is closed access and not available.
The structure-activity relationships for semicarbazide-sensitive amine oxidase (SSAO) inhibitors based on arylpropynylamines was investigated using solution-phase combinatorial Sonogashira coupling. The results suggest that binding to the active site occurs by coordination of the amine to the proximal copper(II) and formation of a π-complex between topaquinone and the electron-rich aryl group of the inhibitor. © 2001 Elsevier Science Ltd. All rights reserved.
Please use this identifier to cite or link to this item: