Associations between insulin and glucose concentrations and anthropometric measures of fat mass in Australian adolescents

Denney-Wilson, E; Cowell, CT; Okely, AD; Hardy, LL; Aitken, R; Dobbins, T

Associations between insulin and glucose concentrations and anthropometric measures of fat mass in Australian adolescents

Denney-Wilson, E

Cowell, CT Okely, AD Hardy, LL Aitken, R Dobbins, T

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Publication Type:: Journal Article
Citation:: BMC Pediatrics, 2010, 10
Issue Date:: 2010-08-11

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Field	Value	Language
dc.contributor.author	Denney-Wilson, E https://orcid.org/0000-0001-9879-4969	en_US
dc.contributor.author	Cowell, CT	en_US
dc.contributor.author	Okely, AD	en_US
dc.contributor.author	Hardy, LL	en_US
dc.contributor.author	Aitken, R	en_US
dc.contributor.author	Dobbins, T	en_US
dc.date.issued	2010-08-11	en_US
dc.identifier.citation	BMC Pediatrics, 2010, 10	en_US
dc.identifier.uri	http://hdl.handle.net/10453/32467
dc.description.abstract	Background: One of the most serious, yet common co-morbidities of obesity is insulin resistance, which if untreated may progress to type 2 diabetes. This paper describes the insulin and glucose concentration distributions, the prevalence of elevated insulin, the associations between insulin and body mass index (BMI), waist circumference, waist-to-height ratio (WHtR) and fat mass index in a representative sample of Australian adolescents.Methods: Cross-sectional population-based study of adolescent boys and girls (N = 496, mean age 15.3 years) attending schools in metropolitan Sydney, Australia. Fasting venous blood collected and analysed for insulin and glucose concentrations. Height, weight, waist circumference measured, BMI and waist-to-height ratio calculated. Pubertal status self-reported.Results: Glucose concentrations were normally distributed and were not associated with adiposity. Insulin concentrations were distributed logarithmically, were higher among girls than boys overall and within the same ranges of BMI and waist circumference, but were lower among girls than boys within the same ranges of fat mass adjusted for height. The prevalence of elevated insulin concentration (defined as > 100 pmol/L) was 15.9% and 17.1% among boys and girls, respectively. Correlations between insulin concentration and BMI, waist circumference, WHtR and fat mass adjusted for height were 0.53, 0.49, 0.51 and 0.55, among boys, respectively, and 0.35, 0.40, 0.42 and 0.34, among girls, respectively.Conclusions: Elevated insulin is highly correlated with adiposity in adolescents. BMI and WHtR are simple measures that can be used to identify young people who should be screened for insulin resistance and other co-morbidities. © 2010 Denney-Wilson et al; licensee BioMed Central Ltd.	en_US
dc.relation.ispartof	BMC Pediatrics	en_US
dc.relation.isbasedon	10.1186/1471-2431-10-58	en_US
dc.subject.classification	Pediatrics	en_US
dc.title	Associations between insulin and glucose concentrations and anthropometric measures of fat mass in Australian adolescents	en_US
dc.type	Journal Article
utslib.citation.volume	10	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	10	en_US

Abstract:

Background: One of the most serious, yet common co-morbidities of obesity is insulin resistance, which if untreated may progress to type 2 diabetes. This paper describes the insulin and glucose concentration distributions, the prevalence of elevated insulin, the associations between insulin and body mass index (BMI), waist circumference, waist-to-height ratio (WHtR) and fat mass index in a representative sample of Australian adolescents.Methods: Cross-sectional population-based study of adolescent boys and girls (N = 496, mean age 15.3 years) attending schools in metropolitan Sydney, Australia. Fasting venous blood collected and analysed for insulin and glucose concentrations. Height, weight, waist circumference measured, BMI and waist-to-height ratio calculated. Pubertal status self-reported.Results: Glucose concentrations were normally distributed and were not associated with adiposity. Insulin concentrations were distributed logarithmically, were higher among girls than boys overall and within the same ranges of BMI and waist circumference, but were lower among girls than boys within the same ranges of fat mass adjusted for height. The prevalence of elevated insulin concentration (defined as > 100 pmol/L) was 15.9% and 17.1% among boys and girls, respectively. Correlations between insulin concentration and BMI, waist circumference, WHtR and fat mass adjusted for height were 0.53, 0.49, 0.51 and 0.55, among boys, respectively, and 0.35, 0.40, 0.42 and 0.34, among girls, respectively.Conclusions: Elevated insulin is highly correlated with adiposity in adolescents. BMI and WHtR are simple measures that can be used to identify young people who should be screened for insulin resistance and other co-morbidities. © 2010 Denney-Wilson et al; licensee BioMed Central Ltd.

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http://hdl.handle.net/10453/32467