The population distributions, upper normal limits and correlations between liver tests among Australian adolescents

George, J; Denney-Wilson, E; Okely, AD; Hardy, LL; Aitken, R; Booth, ML

The population distributions, upper normal limits and correlations between liver tests among Australian adolescents

George, J Denney-Wilson, E

Okely, AD Hardy, LL Aitken, R Booth, ML

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Publication Type:: Journal Article
Citation:: Journal of Paediatrics and Child Health, 2008, 44 (10), pp. 579 - 585
Issue Date:: 2008-10-01

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Field	Value	Language
dc.contributor.author	George, J	en_US
dc.contributor.author	Denney-Wilson, E https://orcid.org/0000-0001-9879-4969	en_US
dc.contributor.author	Okely, AD	en_US
dc.contributor.author	Hardy, LL	en_US
dc.contributor.author	Aitken, R	en_US
dc.contributor.author	Booth, ML	en_US
dc.date.issued	2008-10-01	en_US
dc.identifier.citation	Journal of Paediatrics and Child Health, 2008, 44 (10), pp. 579 - 585	en_US
dc.identifier.issn	1034-4810	en_US
dc.identifier.uri	http://hdl.handle.net/10453/32546
dc.description.abstract	Aim: Relatively little is known about the results of liver tests among adolescents. The purpose of this study was to describe the distributions of liver tests, to identify the upper normal limits (UNLs) and to describe the correlations among liver tests. Methods: Overnight fasting blood samples were collected from a representative population sample of 500 Grade 10 students (15 years old) attending schools in Sydney, Australia. Weight, height and waist girth were measured. UNLs were calculated for each enzyme as the 95th percentiles of the healthy body mass index category, after excluding those with high blood pressure, elevated low-density lipoprotein cholesterol (≥3.4 mmol/L) or triglyceride concentration (≥2.25 mmol/L) (n = 246). The distributions of alanine aminotransferase (ALT), γ-glutamyltransferase (GGT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were described, UNLs were identified and the correlations between enzyme concentrations were described. Results: The UNLs for ALT were 32 and 20 U/L; for GGT, 24 and 19 U/L; for AST, 33 and 26 U/L; and for ALP, 385 and 183 U/L, for boys and girls, respectively. ALT concentration was strongly correlated with GGT and AST (r = 0.5-0.6). Neither ALT nor GGT concentrations were correlated with ALP concentration, but AST concentration was moderately correlated with ALP concentration. Conclusions: These data are valuable in defining the distributions of liver tests, normal liver test ranges and relationships between liver tests among adolescents. © 2008 The Authors.	en_US
dc.relation.ispartof	Journal of Paediatrics and Child Health	en_US
dc.relation.isbasedon	10.1111/j.1440-1754.2008.01386.x	en_US
dc.subject.classification	Pediatrics	en_US
dc.subject.mesh	Liver	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Alkaline Phosphatase	en_US
dc.subject.mesh	gamma-Glutamyltransferase	en_US
dc.subject.mesh	Alanine Transaminase	en_US
dc.subject.mesh	Aspartate Aminotransferases	en_US
dc.subject.mesh	Liver Function Tests	en_US
dc.subject.mesh	Reference Values	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Clinical Enzyme Tests	en_US
dc.title	The population distributions, upper normal limits and correlations between liver tests among Australian adolescents	en_US
dc.type	Journal Article
utslib.citation.volume	10	en_US
utslib.citation.volume	44	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1117 Public Health and Health Services	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	closed_access
pubs.issue	10	en_US
pubs.publication-status	Published	en_US
pubs.volume	44	en_US

Abstract:

Aim: Relatively little is known about the results of liver tests among adolescents. The purpose of this study was to describe the distributions of liver tests, to identify the upper normal limits (UNLs) and to describe the correlations among liver tests. Methods: Overnight fasting blood samples were collected from a representative population sample of 500 Grade 10 students (15 years old) attending schools in Sydney, Australia. Weight, height and waist girth were measured. UNLs were calculated for each enzyme as the 95th percentiles of the healthy body mass index category, after excluding those with high blood pressure, elevated low-density lipoprotein cholesterol (≥3.4 mmol/L) or triglyceride concentration (≥2.25 mmol/L) (n = 246). The distributions of alanine aminotransferase (ALT), γ-glutamyltransferase (GGT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were described, UNLs were identified and the correlations between enzyme concentrations were described. Results: The UNLs for ALT were 32 and 20 U/L; for GGT, 24 and 19 U/L; for AST, 33 and 26 U/L; and for ALP, 385 and 183 U/L, for boys and girls, respectively. ALT concentration was strongly correlated with GGT and AST (r = 0.5-0.6). Neither ALT nor GGT concentrations were correlated with ALP concentration, but AST concentration was moderately correlated with ALP concentration. Conclusions: These data are valuable in defining the distributions of liver tests, normal liver test ranges and relationships between liver tests among adolescents. © 2008 The Authors.

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http://hdl.handle.net/10453/32546