Mood changes, obstetric experience and alterations in plasma cortisol, beta-endorphin and corticotrophin releasing hormone during pregnancy and the puerperium

Smith, R; Cubis, J; Brinsmead, M; Lewin, T; Singh, B; Owens, P; Chan, EC; Hall, C; Adler, R; Lovelock, M; Hurt, D; Rowley, M; Nolan, M

Mood changes, obstetric experience and alterations in plasma cortisol, beta-endorphin and corticotrophin releasing hormone during pregnancy and the puerperium

Smith, R Cubis, J Brinsmead, M Lewin, T Singh, B Owens, P Chan, EC Hall, C Adler, R Lovelock, M Hurt, D Rowley, M

Nolan, M

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Publication Type:: Journal Article
Citation:: Journal of Psychosomatic Research, 1990, 34 (1), pp. 53 - 69
Issue Date:: 1990-01-01

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	Smith et al Mood Changes Obstetric Experience and Alterations in Plasma Cortisol, Beta Endorphine, Corticotrophin Releasing HOmrone During Pregnancy and the Puerperium 1990.pdf	Published Version	1.16 MB	Adobe PDF	View/Open

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Field	Value	Language
dc.contributor.author	Smith, R	en_US
dc.contributor.author	Cubis, J	en_US
dc.contributor.author	Brinsmead, M	en_US
dc.contributor.author	Lewin, T	en_US
dc.contributor.author	Singh, B	en_US
dc.contributor.author	Owens, P	en_US
dc.contributor.author	Chan, EC	en_US
dc.contributor.author	Hall, C	en_US
dc.contributor.author	Adler, R	en_US
dc.contributor.author	Lovelock, M	en_US
dc.contributor.author	Hurt, D	en_US
dc.contributor.author	Rowley, M https://orcid.org/0000-0002-0454-0165	en_US
dc.contributor.author	Nolan, M	en_US
dc.date.issued	1990-01-01	en_US
dc.identifier.citation	Journal of Psychosomatic Research, 1990, 34 (1), pp. 53 - 69	en_US
dc.identifier.issn	0022-3999	en_US
dc.identifier.uri	http://hdl.handle.net/10453/33064
dc.description.abstract	The relationships between mood change, obstetric experience and alterations in plasma cortisol, β-endorphin (β-EP) and corticotrophin-releasing hormone (CRH) were examined in a prospective study of 97 primiparous Australian women. Psychological measures were administered between the 28th week of pregnancy and the 3rd postnatal month, including the Profile of Mood States (POMS) and the Montgomery Asberg Depressive Rating Scale (MADRS). Blood samples were collected for cortisol, β-EP and CRH assay on most of these occasions and during labour. Factor analysis was used to identify key subsets of psychological variables for use in the subsequent analyses. 'Mood disturbance' and 'tiredness' factors peaked at 38 weeks' gestation, while 'difficulty falling asleep' was greatest around the time of birth. Cortisol, β-EP and CRH concentrations rose significantly as pregnancy advanced and peaked at birth; plasma CRH correlated with plasma cortisol (r=0.54) and β-EP (r=0.32). Women with the highest 'mood disturbance' and MADRS depression scores at 28 weeks' gestation received significantly more pain relief during labour. Those women whose mood deteriorated from 38 weeks' gestation to postnatal day 2 had larger falls in plasma β-EP after delivery (p<0.01) than those women whose mood improved or remained constant. Women in this mood-deteriorated subgroup also had significantly higher MADRS depression scores at 3 months (p<0.01). Mild antenatal depression (MADRS>13) occured in 5.2% of women and mild postnatal depression in 4.7%. Overall, these data suggest a role for circulating CRH in the regulation of maternal cortisol secretion and significant relationships between maternal postnatal mood states and β-EP and between antenatal mood states and obstetric events. © 1990.	en_US
dc.relation.ispartof	Journal of Psychosomatic Research	en_US
dc.relation.isbasedon	10.1016/0022-3999(90)90008-R	en_US
dc.subject.classification	Psychiatry	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Pregnancy Complications	en_US
dc.subject.mesh	Puerperal Disorders	en_US
dc.subject.mesh	Hydrocortisone	en_US
dc.subject.mesh	Corticotropin-Releasing Hormone	en_US
dc.subject.mesh	beta-Endorphin	en_US
dc.subject.mesh	Follow-Up Studies	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Pilot Projects	en_US
dc.subject.mesh	Mother-Child Relations	en_US
dc.subject.mesh	Depressive Disorder	en_US
dc.subject.mesh	Personality Tests	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Infant, Newborn	en_US
dc.subject.mesh	Female	en_US
dc.title	Mood changes, obstetric experience and alterations in plasma cortisol, beta-endorphin and corticotrophin releasing hormone during pregnancy and the puerperium	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	34	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Midwifery
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	34	en_US

Abstract:

The relationships between mood change, obstetric experience and alterations in plasma cortisol, β-endorphin (β-EP) and corticotrophin-releasing hormone (CRH) were examined in a prospective study of 97 primiparous Australian women. Psychological measures were administered between the 28th week of pregnancy and the 3rd postnatal month, including the Profile of Mood States (POMS) and the Montgomery Asberg Depressive Rating Scale (MADRS). Blood samples were collected for cortisol, β-EP and CRH assay on most of these occasions and during labour. Factor analysis was used to identify key subsets of psychological variables for use in the subsequent analyses. 'Mood disturbance' and 'tiredness' factors peaked at 38 weeks' gestation, while 'difficulty falling asleep' was greatest around the time of birth. Cortisol, β-EP and CRH concentrations rose significantly as pregnancy advanced and peaked at birth; plasma CRH correlated with plasma cortisol (r=0.54) and β-EP (r=0.32). Women with the highest 'mood disturbance' and MADRS depression scores at 28 weeks' gestation received significantly more pain relief during labour. Those women whose mood deteriorated from 38 weeks' gestation to postnatal day 2 had larger falls in plasma β-EP after delivery (p<0.01) than those women whose mood improved or remained constant. Women in this mood-deteriorated subgroup also had significantly higher MADRS depression scores at 3 months (p<0.01). Mild antenatal depression (MADRS>13) occured in 5.2% of women and mild postnatal depression in 4.7%. Overall, these data suggest a role for circulating CRH in the regulation of maternal cortisol secretion and significant relationships between maternal postnatal mood states and β-EP and between antenatal mood states and obstetric events. © 1990.

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http://hdl.handle.net/10453/33064