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SAPrIm 2.0: a semi-automated protocol for mid-throughput soluble HLA immunopeptidomics.

Tanuwidjaya, E Lim Kam Sian, TCC Steele, JR Goncalves, G Woodhouse, IB Chang, J Ooi, JD Schittenhelm, RB Faridi, P

Human leukocyte antigen (HLA) molecules are pivotal in guiding human adaptive immune responses through their presentation of peptide ligands, collectively known as the immunopeptidome. This process...

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Haptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy.

Campelj, DG Timpani, CA Spiesberger, G Formosa, LE Steele, JR Zhang, H Schittenhelm, RB Leow, L Goodman, CA Rybalka, E

BACKGROUND: Anticancer chemotherapy is an underappreciated contributor to cancer cachexia, an often-irreversible body-wasting condition that causes 20%-30% of cancer-related deaths. An obstacle to ...

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Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients.

Yang, C Camargo Tavares, L Lee, H-C Steele, JR Ribeiro, RV Beale, AL Yiallourou, S Carrington, MJ Kaye, DM Head, GA Schittenhelm, RB Marques, FZ

The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined ...

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Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.

Gurung, S Piskopos, J Steele, J Schittenhelm, R Shah, A Cousins, FL Tapmeier, TT Gargett, CE

Endometriosis, a chronic debilitating disease affects 1 in 7-10 girls and women, who have symptoms of severe chronic pain and subfertility and significantly impacts the overall quality of life. Cur...

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Mapping the IMiD-dependent cereblon interactome using BioID-proximity labelling.

Costacurta, M Sandow, JJ Maher, B Susanto, O Vervoort, SJ Devlin, JR Garama, D Condina, MR Steele, JR Kahrood, HV Gough, D Johnstone, RW Shortt, J

Immunomodulatory imide drugs (IMiDs) are central components of therapy for multiple myeloma (MM). IMiDs bind cereblon (CRBN), an adaptor for the CUL4-DDB1-RBX1 E3 ligase to change its substrate spe...

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What, How and Why of a Psychologically Informed Environment (PIE) Within Youth Refuge

Jaman, A Corrales, T Edmanson, C Skouteris, H

Being homeless is broadly understood to be traumagenic. Thus, support services for individuals experiencing homelessness (such as youth refuge) are encouraged to use trauma-informed models of care....

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Impact of trauma and placement in residential or congregate care on the criminalisation of children in England/Wales and Australia

Paterson-Young, C Corrales, T Warren, I McNamara, P

Children in residential care have the most complex needs of all children growing up in Out-of-Home care (OOHC), due to complex trauma from pre-care experiences of abuse and neglect, inadequate ther...

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Discussion of the Knowns and Unknowns of Child Protection During Pregnancy in Australia

Wise, S Corrales, T

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“They just want people in their lives that will be there forever”: A conceptual model of permanency for children and young people in therapeutic residential care

Corrales, T McNamara, P Smith, B Bath, H Clark, E Goodchild, KL Grabda, S Harrison, M McGrady, B

In Australian child protection systems, permanency outcomes are primarily equated with stability in a child's living and caring arrangements. For some children this will mean restoration to family,...

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Loss of endogenous estrogen alters mitochondrial metabolism and muscle clock-related protein Rbm20 in female mdx mice.

Timpani, CA Debrincat, D Kourakis, S Boyer, R Formosa, LE Steele, JR Zhang, H Schittenhelm, RB Russell, AP Rybalka, E Lindsay, A

Female carriers of a Duchenne muscular dystrophy (DMD) gene mutation manifest exercise intolerance and metabolic anomalies that may be exacerbated following menopause due to the loss of estrogen, a...

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